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The map label for this gene is dusC [H]

Identifier: 161869911

GI number: 161869911

Start: 949689

End: 950690

Strand: Direct

Name: dusC [H]

Synonym: NMCC_0943

Alternate gene names: 161869911

Gene position: 949689-950690 (Clockwise)

Preceding gene: 161869910

Following gene: 161869913

Centisome position: 44.1

GC content: 53.89

Gene sequence:

>1002_bases
ATGATTGACGGACAAACAACCGAACCCAAACAAAAAACCCGAATCATCCTTGCCCCTATGCAGGGTCTGGTCGATGACGT
GATGCGCGACCTGCTGACGCGTATTGGCGGCTACGACGAATGCGTCAGCGAATTTGTACGCATTACCCATACCGTGCATT
CCCGATCCATATGGTTAAAATATGTCCCCGAAATCGCCAACGGAAACAAAACGTTTTCCGGCACGCCCTGCACCGTCCAA
CTTTTGGGCAGCGATGCGGACAATATGGCGGCGAATGCGCTGGAAGCCGTCCGCTTCGGTGCGAACAAAATCGATTTGAA
CTTCGGCTGCCCCGCGCCCACCGTCAACAAACACAAAGGCGGCGCAATCCTTTTAAAAGAGCCGGAACTGATATTCCACA
TCGTCAAAACGCTGCGCGGACGTTTGCCCGCACATATTCCGCTCACCGCAAAAATGCGGCTCGGTTACGAAGACAAAAGC
CGGGCTTTGGAATGCGCCTGTGCGATTGCCGAAGGGGGCGCATGCGGACTGACCGTACACGCGCGTACCAAAGCCGAGGG
TTACGAACCGCCGGCGCATTGGGAATGGATAAGGAAAATCCGAGACAGCGTCAATATTCCCGTTACCGCCAACGGCGACG
TTTTCAGCCTGCAAGACTATATCGGCATCAAAACAATCAGCGGCTGCAACAGCGTGATGCTCGGTCGCGGCGCGGTCATC
CGCCCCGATTTGGCGCGGCAAATCAAGCAATACGAGAACGGCGGGCCGGTCAAAGACACGGATTTTGCCGAAGTTTCCAA
ATGGATACGGCAGTTTTTCGAGCTGTGCCTGACAAAAGAGGCAAACAATAAATACCCGATCGCCCGTCTTAAGCAATGGT
TGGGCATGATGAAAAAAACGTTCGACCCGGCGCAAACGCTGTTTGACCGCGTCCGAACGGTTAAGGATGCGGATGAAGTC
CGCCGAATCCTGAACGCATTTGAGCATGAGATAAATGTTTGA

Upstream 100 bases:

>100_bases
GGCGTGGAAAAAGTATTGCTGTAACAACGGACACGGAAATGCCGTCTGAACGCCGAAAGCCTTCAGACGGCATTGTTTAA
ACCCAATACCTACCCAAATC

Downstream 100 bases:

>100_bases
CTGTCTCCCATGCTTCAAAGCAAATGCCGTCTGAAAATCTTTCAGACGGCATTTCATATCTTTATTGCTGCTTTTCTTCC
GTATCCGGCGTATTTTTGTT

Product: tRNA-dihydrouridine synthase C

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MIDGQTTEPKQKTRIILAPMQGLVDDVMRDLLTRIGGYDECVSEFVRITHTVHSRSIWLKYVPEIANGNKTFSGTPCTVQ
LLGSDADNMAANALEAVRFGANKIDLNFGCPAPTVNKHKGGAILLKEPELIFHIVKTLRGRLPAHIPLTAKMRLGYEDKS
RALECACAIAEGGACGLTVHARTKAEGYEPPAHWEWIRKIRDSVNIPVTANGDVFSLQDYIGIKTISGCNSVMLGRGAVI
RPDLARQIKQYENGGPVKDTDFAEVSKWIRQFFELCLTKEANNKYPIARLKQWLGMMKKTFDPAQTLFDRVRTVKDADEV
RRILNAFEHEINV

Sequences:

>Translated_333_residues
MIDGQTTEPKQKTRIILAPMQGLVDDVMRDLLTRIGGYDECVSEFVRITHTVHSRSIWLKYVPEIANGNKTFSGTPCTVQ
LLGSDADNMAANALEAVRFGANKIDLNFGCPAPTVNKHKGGAILLKEPELIFHIVKTLRGRLPAHIPLTAKMRLGYEDKS
RALECACAIAEGGACGLTVHARTKAEGYEPPAHWEWIRKIRDSVNIPVTANGDVFSLQDYIGIKTISGCNSVMLGRGAVI
RPDLARQIKQYENGGPVKDTDFAEVSKWIRQFFELCLTKEANNKYPIARLKQWLGMMKKTFDPAQTLFDRVRTVKDADEV
RRILNAFEHEINV
>Mature_333_residues
MIDGQTTEPKQKTRIILAPMQGLVDDVMRDLLTRIGGYDECVSEFVRITHTVHSRSIWLKYVPEIANGNKTFSGTPCTVQ
LLGSDADNMAANALEAVRFGANKIDLNFGCPAPTVNKHKGGAILLKEPELIFHIVKTLRGRLPAHIPLTAKMRLGYEDKS
RALECACAIAEGGACGLTVHARTKAEGYEPPAHWEWIRKIRDSVNIPVTANGDVFSLQDYIGIKTISGCNSVMLGRGAVI
RPDLARQIKQYENGGPVKDTDFAEVSKWIRQFFELCLTKEANNKYPIARLKQWLGMMKKTFDPAQTLFDRVRTVKDADEV
RRILNAFEHEINV

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family. DusC subfamily [H]

Homologues:

Organism=Homo sapiens, GI31742496, Length=171, Percent_Identity=33.9181286549708, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI239788483, Length=175, Percent_Identity=29.1428571428571, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI40807366, Length=240, Percent_Identity=28.75, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI239788462, Length=175, Percent_Identity=29.1428571428571, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788462, Length=319, Percent_Identity=40.1253918495298, Blast_Score=243, Evalue=9e-66,
Organism=Escherichia coli, GI1789660, Length=248, Percent_Identity=32.6612903225806, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI145693211, Length=289, Percent_Identity=25.6055363321799, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17543114, Length=251, Percent_Identity=26.2948207171315, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI25144369, Length=171, Percent_Identity=29.8245614035088, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507177, Length=171, Percent_Identity=29.8245614035088, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323560, Length=206, Percent_Identity=30.5825242718447, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323437, Length=176, Percent_Identity=27.8409090909091, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585320, Length=201, Percent_Identity=32.3383084577114, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24580595, Length=234, Percent_Identity=29.0598290598291, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19920448, Length=234, Percent_Identity=29.0598290598291, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19921524, Length=264, Percent_Identity=26.8939393939394, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45549423, Length=247, Percent_Identity=27.9352226720648, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 37163; Mature: 37163

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDGQTTEPKQKTRIILAPMQGLVDDVMRDLLTRIGGYDECVSEFVRITHTVHSRSIWLK
CCCCCCCCCHHHCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YVPEIANGNKTFSGTPCTVQLLGSDADNMAANALEAVRFGANKIDLNFGCPAPTVNKHKG
CCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
GAILLKEPELIFHIVKTLRGRLPAHIPLTAKMRLGYEDKSRALECACAIAEGGACGLTVH
CEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
ARTKAEGYEPPAHWEWIRKIRDSVNIPVTANGDVFSLQDYIGIKTISGCNSVMLGRGAVI
ECCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCEEEHHHHHCCEEECCCCCHHCCCCCEE
RPDLARQIKQYENGGPVKDTDFAEVSKWIRQFFELCLTKEANNKYPIARLKQWLGMMKKT
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
FDPAQTLFDRVRTVKDADEVRRILNAFEHEINV
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDGQTTEPKQKTRIILAPMQGLVDDVMRDLLTRIGGYDECVSEFVRITHTVHSRSIWLK
CCCCCCCCCHHHCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YVPEIANGNKTFSGTPCTVQLLGSDADNMAANALEAVRFGANKIDLNFGCPAPTVNKHKG
CCHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
GAILLKEPELIFHIVKTLRGRLPAHIPLTAKMRLGYEDKSRALECACAIAEGGACGLTVH
CEEEEECHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEE
ARTKAEGYEPPAHWEWIRKIRDSVNIPVTANGDVFSLQDYIGIKTISGCNSVMLGRGAVI
ECCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCEEEHHHHHCCEEECCCCCHHCCCCCEE
RPDLARQIKQYENGGPVKDTDFAEVSKWIRQFFELCLTKEANNKYPIARLKQWLGMMKKT
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
FDPAQTLFDRVRTVKDADEVRRILNAFEHEINV
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]