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The map label for this gene is pntA [H]

Identifier: 161869892

GI number: 161869892

Start: 925610

End: 927151

Strand: Reverse

Name: pntA [H]

Synonym: NMCC_0923

Alternate gene names: 161869892

Gene position: 927151-925610 (Counterclockwise)

Preceding gene: 161869902

Following gene: 161869891

Centisome position: 43.05

GC content: 58.11

Gene sequence:

>1542_bases
ATGAAAATCGGTATCCCACGCGAGTCATTATCCGGCGAAACCCGCGTCGCCTGTACGCCCGCCACCGTCGCCCTGCTGGG
CAAACTGGGCTTTGAAACCGTTGTCGAAAGCGGTGCAGGTTTGGCGGCAAGTTTGGACGATGCCGCTTACCAAACAGCAG
GCGCAACCGTTGCCGACAAAGCGGCGGTTTGGGTCTGCCCTTTGATTTATAAGGTCAACGCGCCGTCCGAACAGGAACTG
CCGCTTTTGAACGAAGGTCAAACCATCGTCAGCTTCCTGTGGCCGCGCCAAAACGAGGCTTTGGTCGAAGCCTTGCGCGC
CAAGAAAGTGAACGCGCTGGCGATGGATATGGTGCCCCGCATTTCGCGCGCGCAGGCTTTGGACGCTTTGTCTTCGATGG
CAAACATCAGCGGCTACCGCGCCGTAATTGAAGCCGCCAACGCCTTCGGCCGTTTCTTCACCGGTCAAATTACTGCCGCC
GGCAAAGTGCCGCCTGCGCAGGTTTTGGTGATTGGTGCAGGTGTGGCAGGTTTGGCGGCAATCGGTACGGCAAATTCACT
AGGCGCAGTGGTGCGCGCGTTCGATACCCGCTTGGAAGTGGCGGAACAAATCGAATCGATGGGCGGCAAGTTCCTGAAAC
TCGACTTCCCGCAAGAATCGGGCGGCAGCGGCGACGGCTACGCCAAAGTGATGAGCGACGAATTTATCGCCGCCGAGATG
AAACTCTTTGCCGAGCAGGCGAAAGAAGTGGACATCATCATCACTACCGCCGCCATTCCGGGCAAACCCGCGCCCAAGCT
GATTACCAAAGAAATGGTGGAAAGCATGAAATCCGGCTCCGTCATCGTCGATTTGGCGGCGGCGACGGGCGGCAACTGCG
AACTCACCCGCCCGGGCGAATTGTCCGTAACCGGCAACGGCGTGAAAATCATCGGCTACACCGACATGGCAAACCGCCTT
GCCGGACAGTCTTCCCAGCTTTACGCCACCAACTTGGTGAACCTGACCAAGCTGTTAAGCCCGAACAAAGACGGCGAAAT
CACGCTGGATTTTGAAGACGTGATTATCCGTAACATGACCGTTACCCGCGACGGCGAAATCACCTTCCCGCCTCCGCCGA
TTCAAGTTTCCGCCCAGCCGCAGCAAACGCCGTCTGAAAAAGCCGCGCCTGCCGCCAAGCCCGAGCCGAAACCCGTTCCC
CTGTGGAAAAAACTCGCGCCTGCCGTCATCGCCGCCGTATTAGTGCTGTGGGTCGGCGCGGTCGCACCCGCAGCATTCTT
GAACCACTTTATCGTGTTCGTCCTCGCCTGCGTCATCGGGTACTACGTCGTTTGGAATGTCAGCCACTCGCTGCATACGC
CGCTGATGTCCGTGACCAACGCCATCTCCGGCATCATCGTCGTCGGCGCGCTGCTGCAAATCGGTCAGGGCAACGGCTTT
GTTTCGCTGCTGTCGTTTGTTGCCATCCTGATTGCCGGCATCAACATCTTCGGCGGCTTTGCGGTTACACGGCGTATGCT
GAATATGTTTAAGAAAGGGTAA

Upstream 100 bases:

>100_bases
TGAAGTGAATCGGTTTTAAACCGGTACGGCGTTGCTCCGCCCTGCCCCGATTTAAATTTAACCCACGATACATATAAACT
ACCCGAAAAAGGATTCAGAG

Downstream 100 bases:

>100_bases
GCCATGACTTTCGCCTATTGGTGCATCCTGATTGCCTGCCTATTGCCGCTTTTTTGTGCGGCATATGCCAAAAAAGCGGG
CGGATTCCGGTTTAAAGACA

Product: NAD(P) transhydrogenase subunit alpha

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha; Pyridine nucleotide transhydrogenase subunit alpha [H]

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADKAAVWVCPLIYKVNAPSEQEL
PLLNEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPRISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAA
GKVPPAQVLVIGAGVAGLAAIGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM
KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGELSVTGNGVKIIGYTDMANRL
AGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMTVTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVP
LWKKLAPAVIAAVLVLWVGAVAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF
VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKG

Sequences:

>Translated_513_residues
MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADKAAVWVCPLIYKVNAPSEQEL
PLLNEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPRISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAA
GKVPPAQVLVIGAGVAGLAAIGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM
KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGELSVTGNGVKIIGYTDMANRL
AGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMTVTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVP
LWKKLAPAVIAAVLVLWVGAVAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF
VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKG
>Mature_513_residues
MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADKAAVWVCPLIYKVNAPSEQEL
PLLNEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPRISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAA
GKVPPAQVLVIGAGVAGLAAIGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM
KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGELSVTGNGVKIIGYTDMANRL
AGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMTVTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVP
LWKKLAPAVIAAVLVLWVGAVAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF
VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=537, Percent_Identity=48.6033519553073, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI122939153, Length=537, Percent_Identity=48.6033519553073, Blast_Score=451, Evalue=1e-127,
Organism=Escherichia coli, GI1787887, Length=512, Percent_Identity=68.359375, Blast_Score=687, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=518, Percent_Identity=48.8416988416988, Blast_Score=451, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR004571 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 53843; Mature: 53843

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00836 ALADH_PNT_1 ; PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADK
CCCCCCCHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCHHHC
AAVWVCPLIYKVNAPSEQELPLLNEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPR
HHHEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAAGKVPPAQVLVIGAGVAGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHH
IGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGE
HHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCC
LSVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT
EEEECCCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCEE
VTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVPLWKKLAPAVIAAVLVLWVGA
EECCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGIPRESLSGETRVACTPATVALLGKLGFETVVESGAGLAASLDDAAYQTAGATVADK
CCCCCCCHHCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHCCCCHHHC
AAVWVCPLIYKVNAPSEQELPLLNEGQTIVSFLWPRQNEALVEALRAKKVNALAMDMVPR
HHHEEEEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
ISRAQALDALSSMANISGYRAVIEAANAFGRFFTGQITAAGKVPPAQVLVIGAGVAGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEEEEECCHHHHHH
IGTANSLGAVVRAFDTRLEVAEQIESMGGKFLKLDFPQESGGSGDGYAKVMSDEFIAAEM
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
KLFAEQAKEVDIIITTAAIPGKPAPKLITKEMVESMKSGSVIVDLAAATGGNCELTRPGE
HHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCC
LSVTGNGVKIIGYTDMANRLAGQSSQLYATNLVNLTKLLSPNKDGEITLDFEDVIIRNMT
EEEECCCEEEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCEE
VTRDGEITFPPPPIQVSAQPQQTPSEKAAPAAKPEPKPVPLWKKLAPAVIAAVLVLWVGA
EECCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VAPAAFLNHFIVFVLACVIGYYVVWNVSHSLHTPLMSVTNAISGIIVVGALLQIGQGNGF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
VSLLSFVAILIAGINIFGGFAVTRRMLNMFKKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3525165; 1633824; 9097039; 9278503; 1932078 [H]