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The map label for this gene is dapA [H]

Identifier: 161869841

GI number: 161869841

Start: 874661

End: 875536

Strand: Reverse

Name: dapA [H]

Synonym: NMCC_0872

Alternate gene names: 161869841

Gene position: 875536-874661 (Counterclockwise)

Preceding gene: 161869843

Following gene: 161869840

Centisome position: 40.66

GC content: 60.05

Gene sequence:

>876_bases
ATGTTACAAGGTAGCCTGGTTGCCCTGATTACCCCGATGAATCAAGACGGCAGCATCCATTACGAACAACTCCGCGACTT
AATCGACTGGCACATTGAAAACGGCACGGACGGCATCGTTGCCGTCGGCACGACAGGCGAATCCGCCACCCTCTCCGTCG
AAGAACACACCGCCGTCATCGAAGCCGTCGTCAAACACGTTGCCAAACGCGTCCCCGTCATCGCCGGCACAGGGGCAAAC
AACACCGTCGAAGCCATCGCCCTTTCCCAAGCCGCCGAAAAAGCCGGGGCGGACTACACCCTCTCCGTCGTCCCCTATTA
CAACAAACCTTCGCAAGAAGGCATGTACCGCCATTTCAAAGCCGTTGCCGAAGCCGCCGCGATTCCGATGATACTCTACA
ACGTACCCGGCAGAACCGTCGTCAGCATGAACAACGAAACCATCCTGCGCCTTGCCGAAATCCCCAACATCGTCGGCGTG
AAAGAAGCCAGCGGCAACATCGGCAGCAACATCGAACTCATCAACCGCGCGCCCGAAGGCTTCTTCGTCCTTTCCGGCGA
CGACCATACCGCCCTGCCGTTCATGCTGTGCGGCGGACACGGCGTGATTACCGTAGCCGCCAACGCCGCGCCCAAGCTCT
TTGCCGATATGTGCCGCGCCGCGCTTCAAGGCGATATCGCCCTTGCACGCGAACTCAACGACCGGCTGATTCCGATTTAC
GACACCATGTTCTGCGAACCCAGCCCCGCCGCACCGAAATGGGCGGTATCCGCCCTGGGCAGATGCGAACCGCACGTCCG
CCTGCCGCTCGTTCCGCTGACGGAAGGCGGACAGGCAAAAGTCCGCGCCGCCCTGAAAGCCTCAGGACAACTTTAA

Upstream 100 bases:

>100_bases
CCCGCTCATCCCGGACCCGCCGGATTTCACACCTGCGGTAAAGTAGGCTACAATCGGAAGCATTACCGCCCCCTACACCA
CAACTGATAAAAGGTTCTGT

Downstream 100 bases:

>100_bases
ATATAGCCATGCCGTCTGAAGCGTTCAGACGGCATAACGCAACAAACACTTTAATATCCATCACACAGGATGACACGATG
ACCCATATCAAACCCGTCAT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVIEAVVKHVAKRVPVIAGTGAN
NTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFKAVAEAAAIPMILYNVPGRTVVSMNNETILRLAEIPNIVGV
KEASGNIGSNIELINRAPEGFFVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIY
DTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL

Sequences:

>Translated_291_residues
MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVIEAVVKHVAKRVPVIAGTGAN
NTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFKAVAEAAAIPMILYNVPGRTVVSMNNETILRLAEIPNIVGV
KEASGNIGSNIELINRAPEGFFVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIY
DTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL
>Mature_291_residues
MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVIEAVVKHVAKRVPVIAGTGAN
NTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFKAVAEAAAIPMILYNVPGRTVVSMNNETILRLAEIPNIVGV
KEASGNIGSNIELINRAPEGFFVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIY
DTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI13540533, Length=235, Percent_Identity=32.3404255319149, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI31543060, Length=233, Percent_Identity=26.1802575107296, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=48.972602739726, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI87082415, Length=285, Percent_Identity=33.3333333333333, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786463, Length=285, Percent_Identity=33.3333333333333, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1789620, Length=243, Percent_Identity=28.3950617283951, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 30855; Mature: 30855

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVI
CCCCCEEEEEECCCCCCCEEHHHHHHHHHEEECCCCCCEEEEECCCCCEEEEHHHHHHHH
EAVVKHVAKRVPVIAGTGANNTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFK
HHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHH
AVAEAAAIPMILYNVPGRTVVSMNNETILRLAEIPNIVGVKEASGNIGSNIELINRAPEG
HHHHHHHCCEEEEECCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCC
FFVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIY
EEEEECCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCCEEEEE
DTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL
HEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHEEEHHCCCC
>Mature Secondary Structure
MLQGSLVALITPMNQDGSIHYEQLRDLIDWHIENGTDGIVAVGTTGESATLSVEEHTAVI
CCCCCEEEEEECCCCCCCEEHHHHHHHHHEEECCCCCCEEEEECCCCCEEEEHHHHHHHH
EAVVKHVAKRVPVIAGTGANNTVEAIALSQAAEKAGADYTLSVVPYYNKPSQEGMYRHFK
HHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHH
AVAEAAAIPMILYNVPGRTVVSMNNETILRLAEIPNIVGVKEASGNIGSNIELINRAPEG
HHHHHHHCCEEEEECCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCC
FFVLSGDDHTALPFMLCGGHGVITVAANAAPKLFADMCRAALQGDIALARELNDRLIPIY
EEEEECCCCCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHCCCCEEEEE
DTMFCEPSPAAPKWAVSALGRCEPHVRLPLVPLTEGGQAKVRAALKASGQL
HEEECCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCHHHHHEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA