| Definition | Neisseria meningitidis 053442, complete genome. |
|---|---|
| Accession | NC_010120 |
| Length | 2,153,416 |
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The map label for this gene is icd [H]
Identifier: 161869830
GI number: 161869830
Start: 863140
End: 865362
Strand: Reverse
Name: icd [H]
Synonym: NMCC_0861
Alternate gene names: 161869830
Gene position: 865362-863140 (Counterclockwise)
Preceding gene: 161869833
Following gene: 161869829
Centisome position: 40.19
GC content: 54.03
Gene sequence:
>2223_bases ATGACTAAATCCACCATTATCTATACCTACACCGACGAAGCTCCTGCATTGGCCACTCAATCCCTGTTGCCAATCGTACA GGCGTTTACCCGCCATGCCGATATTGATGTCAAAACCAGCGACATCTCTCTCTCCGGCCGTATTTTGGCGGCGTTTCCAG AATACCTGACCGAAGCGCAACGCGTACCTGATGCGCTTGCCGAATTGGGCGAACTGGTGAAACAACCCGATGCAAACGTA ATCAAACTGCCGAACATCAGCGCGTCCGTACCTCAACTGACTGCCGCGATTAAAGAATTACAGTCTAAAGGCTTTGCCGT TCCCGACTATCCTGCTGACCCTCAAACCGATGAAGAAAAAGCCGTACGCGAACGCTACGACCGCATCAAAGGCAGCGCGG TAAACCCTGTCCTGCGTGAAGGCAACTCCGACCGTCGCGCCCCTAAAGCAGTGAAAAACTTTGCGAAAAAACATCCGCAC AGCATGGGCGCATGGACGAAAGACTCAAAAACCCACGTTGCCACCATGCAAAGCGGCGACTTTTTCCATAACGAACAATC CGTTACCGTACCTGAAGCGACTTCCGTATCCATCGTATTCACCGACAAACAAGGCAACAAAAAAGAGCTGCGCGCGCCCG TCGCCCTGAAAGCCGGCGAAATCATCGACGCGACCGTGATGAGCAAAAAAGCCCTGCTCGCCTTCCTTGCCGAACAAGTG AAAGACGCGAAAGCAAAAGGCGTATTGTTCTCGCTGCATATGAAAGCCACGATGATGAAAGTGTCCGACCCGATTATCTT CGGACACGCCGTCAAAGTGTTCTTTGCGCCTGTTTTTGAAAAATTCGGCGACAAATTGGCTGCCGCCGGCGTCAACGTCA ACAACGGCTTCGGCAACCTGCTTGCCAATTTGGACAAACTGGATGCGGACACCCGCGCAGCCGTTGAAGCTGAAATCGCC GCCGTTTACGCCGCCAACCCCGATTTGGCGATGGTTGATTCCGACAAAGGCATCACCAACCTGCACGTTCCCAGCGATGT CATCGTCGATGCCTCTATGCCTGCAATGATTCGCAACTCCGGCCGTATGTGGGATAAAGACGGCAAAGCGCAAGACACCA AAGCCGTGATTCCCGACAGTAGCTACGCAGGCGTTTATCAAGCAACCATCGACTTCTGCCGCGAACACGGCGCATTCGAC CCGACAACCATGGGTACCGTTCCTAACGTCGGTCTGATGGCGCAAGCAGCCGAAGAATACGGTTCACACAACAAAACTTT CGAAATCGAAGCCGACGGCCAAGTTCAAGTCATTGATGCAGCGGGCAAAGTCCTGATGCAGCACGATGTTGAAGCAGGCG ACATCTGGCGTATGTGTCAAACCAAAGACGCGCCCGTCAAAGACTGGGTACAACTCGCCGTCAACCGCGCCCGTCTGAGC AATACACCAGCCGTATTCTGGCTCGATGAAAACCGTCCGCACGACAAGAGCCTGCTCGCCAAGGTTAAAGCCTACCTTGC CGAACTGGATACCGACGGCCTCGACATCCGCGTCCTCGCTCCCGAAGAAGCCGCTAAATTCAGCTTAGGCCGTCTGAAAA ACGGCGAAGACACCATCTCCGTAACCGGCAACGTCCTGCGCGACTACCTGACCGACTTGTTCCCGATTTTGGAACTGGGT ACCAGCGCGAAAATGCTGTCTATCGTCCCATTGATGAACGGCGGCGGTATGTTTGAAACCGGCGCGGGCGGTTCTGCACC GAAACACGTTCAACAATTCCTCGAAGAAAACCACTTGCGTTGGGACTCTTTGGGCGAATTCCTCGCACTCGCCGTATCGT TTGAACATTTGGCGCAAAAAACCGGCAACGCCAAAGCCCAAGTCCTCGCCGACACTTTGGATGCAGCCACCGAAAAACTG CTGTTGAACGACAAATCGCCTAAACGCAAAGCAGGCGAACTCGACAACCGCGGCAGCCATTTCTACCTTACCCTCTACTG GGCGCAAGAATTGGCGGCGCAAGACAAAGATGCCGAACTGAAAGCCGCATTTACGCCATTGGCAGCCGCTTTGACCGCCG ACGAAGCGAAAATCGTTGCCGAGCTTTCCGCCGTACAAGGCAAAGCGGCCGACATCGGCGGCTACTACGCCGCCAATCCT GAAAAAGCCGCACAAGTGATGCGTCCGAGCGTAACCTTTAATCAGGCACTAAACGCCTTATAA
Upstream 100 bases:
>100_bases AAAGCGCGAACAAAGCCGCCAAAATATGCCATAATAGCCGCGCACATTCCCCGCGCAATGTGTTCCAAAAGAAAAAACCA ACCTACAAGAGAATAATCCC
Downstream 100 bases:
>100_bases GCACAAAGGTAAAAATGCCGTCTGAACATTCGTCGTTCAGACGGCATTAGTTATCCCTATCTGCCTGATTATGATTAAAC GCCGCACCCATTGGATATAA
Product: isocitrate dehydrogenase
Products: NA
Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]
Number of amino acids: Translated: 740; Mature: 739
Protein sequence:
>740_residues MTKSTIIYTYTDEAPALATQSLLPIVQAFTRHADIDVKTSDISLSGRILAAFPEYLTEAQRVPDALAELGELVKQPDANV IKLPNISASVPQLTAAIKELQSKGFAVPDYPADPQTDEEKAVRERYDRIKGSAVNPVLREGNSDRRAPKAVKNFAKKHPH SMGAWTKDSKTHVATMQSGDFFHNEQSVTVPEATSVSIVFTDKQGNKKELRAPVALKAGEIIDATVMSKKALLAFLAEQV KDAKAKGVLFSLHMKATMMKVSDPIIFGHAVKVFFAPVFEKFGDKLAAAGVNVNNGFGNLLANLDKLDADTRAAVEAEIA AVYAANPDLAMVDSDKGITNLHVPSDVIVDASMPAMIRNSGRMWDKDGKAQDTKAVIPDSSYAGVYQATIDFCREHGAFD PTTMGTVPNVGLMAQAAEEYGSHNKTFEIEADGQVQVIDAAGKVLMQHDVEAGDIWRMCQTKDAPVKDWVQLAVNRARLS NTPAVFWLDENRPHDKSLLAKVKAYLAELDTDGLDIRVLAPEEAAKFSLGRLKNGEDTISVTGNVLRDYLTDLFPILELG TSAKMLSIVPLMNGGGMFETGAGGSAPKHVQQFLEENHLRWDSLGEFLALAVSFEHLAQKTGNAKAQVLADTLDAATEKL LLNDKSPKRKAGELDNRGSHFYLTLYWAQELAAQDKDAELKAAFTPLAAALTADEAKIVAELSAVQGKAADIGGYYAANP EKAAQVMRPSVTFNQALNAL
Sequences:
>Translated_740_residues MTKSTIIYTYTDEAPALATQSLLPIVQAFTRHADIDVKTSDISLSGRILAAFPEYLTEAQRVPDALAELGELVKQPDANV IKLPNISASVPQLTAAIKELQSKGFAVPDYPADPQTDEEKAVRERYDRIKGSAVNPVLREGNSDRRAPKAVKNFAKKHPH SMGAWTKDSKTHVATMQSGDFFHNEQSVTVPEATSVSIVFTDKQGNKKELRAPVALKAGEIIDATVMSKKALLAFLAEQV KDAKAKGVLFSLHMKATMMKVSDPIIFGHAVKVFFAPVFEKFGDKLAAAGVNVNNGFGNLLANLDKLDADTRAAVEAEIA AVYAANPDLAMVDSDKGITNLHVPSDVIVDASMPAMIRNSGRMWDKDGKAQDTKAVIPDSSYAGVYQATIDFCREHGAFD PTTMGTVPNVGLMAQAAEEYGSHNKTFEIEADGQVQVIDAAGKVLMQHDVEAGDIWRMCQTKDAPVKDWVQLAVNRARLS NTPAVFWLDENRPHDKSLLAKVKAYLAELDTDGLDIRVLAPEEAAKFSLGRLKNGEDTISVTGNVLRDYLTDLFPILELG TSAKMLSIVPLMNGGGMFETGAGGSAPKHVQQFLEENHLRWDSLGEFLALAVSFEHLAQKTGNAKAQVLADTLDAATEKL LLNDKSPKRKAGELDNRGSHFYLTLYWAQELAAQDKDAELKAAFTPLAAALTADEAKIVAELSAVQGKAADIGGYYAANP EKAAQVMRPSVTFNQALNAL >Mature_739_residues TKSTIIYTYTDEAPALATQSLLPIVQAFTRHADIDVKTSDISLSGRILAAFPEYLTEAQRVPDALAELGELVKQPDANVI KLPNISASVPQLTAAIKELQSKGFAVPDYPADPQTDEEKAVRERYDRIKGSAVNPVLREGNSDRRAPKAVKNFAKKHPHS MGAWTKDSKTHVATMQSGDFFHNEQSVTVPEATSVSIVFTDKQGNKKELRAPVALKAGEIIDATVMSKKALLAFLAEQVK DAKAKGVLFSLHMKATMMKVSDPIIFGHAVKVFFAPVFEKFGDKLAAAGVNVNNGFGNLLANLDKLDADTRAAVEAEIAA VYAANPDLAMVDSDKGITNLHVPSDVIVDASMPAMIRNSGRMWDKDGKAQDTKAVIPDSSYAGVYQATIDFCREHGAFDP TTMGTVPNVGLMAQAAEEYGSHNKTFEIEADGQVQVIDAAGKVLMQHDVEAGDIWRMCQTKDAPVKDWVQLAVNRARLSN TPAVFWLDENRPHDKSLLAKVKAYLAELDTDGLDIRVLAPEEAAKFSLGRLKNGEDTISVTGNVLRDYLTDLFPILELGT SAKMLSIVPLMNGGGMFETGAGGSAPKHVQQFLEENHLRWDSLGEFLALAVSFEHLAQKTGNAKAQVLADTLDAATEKLL LNDKSPKRKAGELDNRGSHFYLTLYWAQELAAQDKDAELKAAFTPLAAALTADEAKIVAELSAVQGKAADIGGYYAANPE KAAQVMRPSVTFNQALNAL
Specific function: Unknown
COG id: COG2838
COG function: function code C; Monomeric isocitrate dehydrogenase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: NA
Operon status: Not Known
Operon components: None
Similarity: Belongs to the monomeric-type IDH family [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001804 - InterPro: IPR004436 [H]
Pfam domain/function: PF03971 IDH [H]
EC number: =1.1.1.42 [H]
Molecular weight: Translated: 80031; Mature: 79899
Theoretical pI: Translated: 5.55; Mature: 5.55
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTKSTIIYTYTDEAPALATQSLLPIVQAFTRHADIDVKTSDISLSGRILAAFPEYLTEAQ CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCHHHHHHHHHHHHH RVPDALAELGELVKQPDANVIKLPNISASVPQLTAAIKELQSKGFAVPDYPADPQTDEEK HHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH AVRERYDRIKGSAVNPVLREGNSDRRAPKAVKNFAKKHPHSMGAWTKDSKTHVATMQSGD HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC FFHNEQSVTVPEATSVSIVFTDKQGNKKELRAPVALKAGEIIDATVMSKKALLAFLAEQV CCCCCCCEECCCCCEEEEEEECCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHH KDAKAKGVLFSLHMKATMMKVSDPIIFGHAVKVFFAPVFEKFGDKLAAAGVNVNNGFGNL HHHHHCCEEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHH LANLDKLDADTRAAVEAEIAAVYAANPDLAMVDSDKGITNLHVPSDVIVDASMPAMIRNS HHHHHHCCCCHHHHHHHEEEEEEECCCCEEEEECCCCCEEEECCCCEEECCCCCHHHHCC GRMWDKDGKAQDTKAVIPDSSYAGVYQATIDFCREHGAFDPTTMGTVPNVGLMAQAAEEY CCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH GSHNKTFEIEADGQVQVIDAAGKVLMQHDVEAGDIWRMCQTKDAPVKDWVQLAVNRARLS CCCCCEEEEECCCCEEEEECCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC NTPAVFWLDENRPHDKSLLAKVKAYLAELDTDGLDIRVLAPEEAAKFSLGRLKNGEDTIS CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEE VTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGMFETGAGGSAPKHVQQFLEENHLR ECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCC WDSLGEFLALAVSFEHLAQKTGNAKAQVLADTLDAATEKLLLNDKSPKRKAGELDNRGSH HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE FYLTLYWAQELAAQDKDAELKAAFTPLAAALTADEAKIVAELSAVQGKAADIGGYYAANP EEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEECCCH EKAAQVMRPSVTFNQALNAL HHHHHHHCCCCHHHHHHCCC >Mature Secondary Structure TKSTIIYTYTDEAPALATQSLLPIVQAFTRHADIDVKTSDISLSGRILAAFPEYLTEAQ CCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCEECCCHHHHHHHHHHHHH RVPDALAELGELVKQPDANVIKLPNISASVPQLTAAIKELQSKGFAVPDYPADPQTDEEK HHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH AVRERYDRIKGSAVNPVLREGNSDRRAPKAVKNFAKKHPHSMGAWTKDSKTHVATMQSGD HHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCC FFHNEQSVTVPEATSVSIVFTDKQGNKKELRAPVALKAGEIIDATVMSKKALLAFLAEQV CCCCCCCEECCCCCEEEEEEECCCCCHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHH KDAKAKGVLFSLHMKATMMKVSDPIIFGHAVKVFFAPVFEKFGDKLAAAGVNVNNGFGNL HHHHHCCEEEEEEHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHCCCCCCCCHHHH LANLDKLDADTRAAVEAEIAAVYAANPDLAMVDSDKGITNLHVPSDVIVDASMPAMIRNS HHHHHHCCCCHHHHHHHEEEEEEECCCCEEEEECCCCCEEEECCCCEEECCCCCHHHHCC GRMWDKDGKAQDTKAVIPDSSYAGVYQATIDFCREHGAFDPTTMGTVPNVGLMAQAAEEY CCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH GSHNKTFEIEADGQVQVIDAAGKVLMQHDVEAGDIWRMCQTKDAPVKDWVQLAVNRARLS CCCCCEEEEECCCCEEEEECCCHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC NTPAVFWLDENRPHDKSLLAKVKAYLAELDTDGLDIRVLAPEEAAKFSLGRLKNGEDTIS CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCCCCEEE VTGNVLRDYLTDLFPILELGTSAKMLSIVPLMNGGGMFETGAGGSAPKHVQQFLEENHLR ECHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCC WDSLGEFLALAVSFEHLAQKTGNAKAQVLADTLDAATEKLLLNDKSPKRKAGELDNRGSH HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE FYLTLYWAQELAAQDKDAELKAAFTPLAAALTADEAKIVAELSAVQGKAADIGGYYAANP EEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCEECCCH EKAAQVMRPSVTFNQALNAL HHHHHHHCCCCHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12005040; 4149369; 12467571 [H]