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The map label for this gene is pth [H]

Identifier: 161869739

GI number: 161869739

Start: 766378

End: 766956

Strand: Reverse

Name: pth [H]

Synonym: NMCC_0759

Alternate gene names: 161869739

Gene position: 766956-766378 (Counterclockwise)

Preceding gene: 161869740

Following gene: 161869738

Centisome position: 35.62

GC content: 54.58

Gene sequence:

>579_bases
ATGTCAAACACAATCAAAATGGTTGTCGGCTTGGGCAACCCGGGCAAAGAATACGAACAGACACGCCACAATGCGGGTTT
TTGGTTCCTCGACGAACTGGCGTGGAAATGGAAGGCTTCATTTAAAGAAGAAAAAAAATTCTTCGGCGAAGTCGCCCGTG
CCGCCCTGCCCGACGGCGACGTTTGGCTGCTCAAACCTGCCACGTTCATGAACCGTTCCGGACAGGCAATTGCCGCCCTT
GCGCAGTTTTATAAAATCAAACCCGAAGAAATCCTCGTCGTCCACGACGAACTCGACATTCCCTGCGGACGGATTAAATT
CAAACTCGGCGGCGGCAACGGCGGACACAACGGCTTGAAAGACATTCAGGCAAAACTCGGCACGGCAGACTATTACCGCC
TGCGCCTCGGTATCGACCACCCAGGCGACCGCAACCTCGTCGTCGGCTATGTCCTGAACAAACCCAGTACGGAACACCGC
CGACAGATTGACGATGCCGTCGCCAAATCCCTGCAAGCCATACCCGACATCCTTGCCGGCAAATGGGAAGAAGCAACCCG
CTTCCTGCACAGCAAATGA

Upstream 100 bases:

>100_bases
GACCCCAAAGAAGCGCGCCGCAAACGCGTTCAAAATCAAGAAGAATAACCATGCCGTCTGAAGCCTTCAGACAGCATTCG
ACAGAAACACGGAAAATATC

Downstream 100 bases:

>100_bases
CCCGATGCCGTCTGAAGCCCTTTCAGACGGCATGTTCCCGATTTCCATATCCGAACAGTCATGACCGAACTCAAGCAGCT
TATCCAAACCGAATCCATCC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGDVWLLKPATFMNRSGQAIAAL
AQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLKDIQAKLGTADYYRLRLGIDHPGDRNLVVGYVLNKPSTEHR
RQIDDAVAKSLQAIPDILAGKWEEATRFLHSK

Sequences:

>Translated_192_residues
MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGDVWLLKPATFMNRSGQAIAAL
AQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLKDIQAKLGTADYYRLRLGIDHPGDRNLVVGYVLNKPSTEHR
RQIDDAVAKSLQAIPDILAGKWEEATRFLHSK
>Mature_191_residues
SNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGDVWLLKPATFMNRSGQAIAALA
QFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLKDIQAKLGTADYYRLRLGIDHPGDRNLVVGYVLNKPSTEHRR
QIDDAVAKSLQAIPDILAGKWEEATRFLHSK

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=148, Percent_Identity=38.5135135135135, Blast_Score=103, Evalue=7e-23,
Organism=Escherichia coli, GI1787455, Length=189, Percent_Identity=54.4973544973545, Blast_Score=187, Evalue=3e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 21546; Mature: 21415

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGD
CCCEEEEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VWLLKPATFMNRSGQAIAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK
EEEECCHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHH
DIQAKLGTADYYRLRLGIDHPGDRNLVVGYVLNKPSTEHRRQIDDAVAKSLQAIPDILAG
HHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
KWEEATRFLHSK
CHHHHHHHHCCC
>Mature Secondary Structure 
SNTIKMVVGLGNPGKEYEQTRHNAGFWFLDELAWKWKASFKEEKKFFGEVARAALPDGD
CCEEEEEEECCCCCHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VWLLKPATFMNRSGQAIAALAQFYKIKPEEILVVHDELDIPCGRIKFKLGGGNGGHNGLK
EEEECCHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCHHH
DIQAKLGTADYYRLRLGIDHPGDRNLVVGYVLNKPSTEHRRQIDDAVAKSLQAIPDILAG
HHHHHCCCCEEEEEEECCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCC
KWEEATRFLHSK
CHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA