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The map label for this gene is dnaA [H]

Identifier: 161869312

GI number: 161869312

Start: 321373

End: 322779

Strand: Direct

Name: dnaA [H]

Synonym: NMCC_0317

Alternate gene names: 161869312

Gene position: 321373-322779 (Clockwise)

Preceding gene: 161869307

Following gene: 161869313

Centisome position: 14.92

GC content: 54.3

Gene sequence:

>1407_bases
ATGCTCAAGAGCCAGTTTGCCGGAAAAATAGAAGCGGTGAGGGAAGAGTTGGCTGCCGGCCGTTCCGCCTTCGTATTCAA
ACCGGGAGAAGGCGTGCGTTATGAGATGGCGGCGGTTGAAGGTGCTGTCGAACCTGCCGAGCCGTCCTTGCACGCGGGGT
CGGAGGAGATGCCTGTGCAGGAGGTTCTGTTGGATGAGCTGCCGTCTGAAGAGCCTGTCAAACCCGCTGCGTCGAAAACG
GCGGCGGATATTTTGGCGGAACGTATGAGAAACCTGCCGCACGAGCCGCGCCATACTGCCGAACCTGCTTCCCGTCCGGA
ATCGGAGGTGCTTGCGAAAGCGCGGACGGATGCGCAGCGCGATGCGGAAGAGGCGCGTTACGAGCAGACCAATCTGTCGC
CGGATTATACGTTCGATACATTGGTCGAAGGCAAGGGCAACCGCCTTGCGGCGGCTGCCGCGCAGGCGATTGCGGAAAGC
CCGGGGCAGAGCTACAACCCGTTTTTCCTCTATGGCAGTACGGGTTTGGGTAAAACCCACTTGGTTCAGGCCATCGGCAA
CGAGCTTTTGAAAAACCGTCCCGACGCGAAAGTACGCTATATGCATTCGGACGATTATATCCGCAGCTTCATGAAAGCCG
TGCGCAACAACACTTACGACGTGTTCAAACAGCAATACAAGCAATACGACCTGCTGATTATCGACGACATCCAGTTCATC
AAAGGCAAAGACCGTACGATGGAAGAGTTTTTCTATCTGTACAACCATTTCCACAACGAGAAAAAACAGCTCATCCTCAC
TTGCGATGTTTTACCCGCCAAAATCGAAGGTATGGACGACCGCCTCAAATCCCGTTTTTCATGGGGACTGACTTTGGAAC
TCGAGCCGCCCGAATTGGAAATGCGTATCGCCATTTTGCAGAAAAAGGCGGAAGCGGCGGGCATCAGTATCGAAGACGAA
GCCGCGCTGTTCATTGCCAATCTGATCCGTTCCAACGTGCGCGAGCTTGAAGGCGCGTTCAACCGTGTCGGAGCGAGCAG
CCGCTTTATGAACCGTCCCGTCATCGACATCGATTTGGCGCGTACCGCTTTGCAGGACATTATTGCCGAGAAGCATAAGG
TCATTACCGCCGATATCATTATTGATGCCGTTGCCAAATATTACCGTATCAAAATCAGCGATGTGCTCGGTAAGAAACGG
ACACGAAACATTGCCCGTCCGCGCCAGGTGGCGATGAGCCTGACCAAAGAACTGACCACTTTGAGCCTGCCGTCTATCGG
CGATTCGTTCGGTGGGCGCGACCATACGACCGTTATGCACGGCATCAGGGCAGTGGCGAAACTGCGCGAAGAAGATCCGG
AATTGGCTCAGGATTATGAAAAGCTGCTGATTCTGATTCAAAACTGA

Upstream 100 bases:

>100_bases
GTTGCCTCAAGGGCAGTTTGCGCAATGGATTGCGCCCCTTACCGTCGGTGAGGAGGGGGGCGTATGGGTGGTGTACGGCA
AGAACCAGTTTGCCTGCAAT

Downstream 100 bases:

>100_bases
TGGAAAACGTTTTCAGACGACATGATATTGCCCATGCCGTCCGAAGGGTAAAGATATAGCGGATTAAATTTAAACCAGTA
CAGCGTTGCCTCGCCTTAGC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAGSEEMPVQEVLLDELPSEEPVKPAASKT
AADILAERMRNLPHEPRHTAEPASRPESEVLAKARTDAQRDAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAES
PGQSYNPFFLYGSTGLGKTHLVQAIGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFI
KGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELEMRIAILQKKAEAAGISIEDE
AALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLARTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKR
TRNIARPRQVAMSLTKELTTLSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN

Sequences:

>Translated_468_residues
MLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAGSEEMPVQEVLLDELPSEEPVKPAASKT
AADILAERMRNLPHEPRHTAEPASRPESEVLAKARTDAQRDAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAES
PGQSYNPFFLYGSTGLGKTHLVQAIGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFI
KGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELEMRIAILQKKAEAAGISIEDE
AALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLARTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKR
TRNIARPRQVAMSLTKELTTLSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN
>Mature_468_residues
MLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAGSEEMPVQEVLLDELPSEEPVKPAASKT
AADILAERMRNLPHEPRHTAEPASRPESEVLAKARTDAQRDAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAES
PGQSYNPFFLYGSTGLGKTHLVQAIGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFI
KGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELEMRIAILQKKAEAAGISIEDE
AALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLARTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKR
TRNIARPRQVAMSLTKELTTLSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=335, Percent_Identity=52.8358208955224, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52562; Mature: 52562

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAGSEEMPVQ
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCHH
EVLLDELPSEEPVKPAASKTAADILAERMRNLPHEPRHTAEPASRPESEVLAKARTDAQR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAESPGQSYNPFFLYGSTGLGKTH
HHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHH
LVQAIGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFI
HHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCHHHH
KGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELE
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCHHHHHHHHHCCCEEEEECCCCHH
MRIAILQKKAEAAGISIEDEAALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEHHHH
RTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKRTRNIARPRQVAMSLTKELTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHH
LSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECC
>Mature Secondary Structure
MLKSQFAGKIEAVREELAAGRSAFVFKPGEGVRYEMAAVEGAVEPAEPSLHAGSEEMPVQ
CCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEHHHHHCCCCCCCCCCCCCCCCCCHH
EVLLDELPSEEPVKPAASKTAADILAERMRNLPHEPRHTAEPASRPESEVLAKARTDAQR
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
DAEEARYEQTNLSPDYTFDTLVEGKGNRLAAAAAQAIAESPGQSYNPFFLYGSTGLGKTH
HHHHHHHHHCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCHHH
LVQAIGNELLKNRPDAKVRYMHSDDYIRSFMKAVRNNTYDVFKQQYKQYDLLIIDDIQFI
HHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEECCHHHH
KGKDRTMEEFFYLYNHFHNEKKQLILTCDVLPAKIEGMDDRLKSRFSWGLTLELEPPELE
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCHHHHHHHHHCCCEEEEECCCCHH
MRIAILQKKAEAAGISIEDEAALFIANLIRSNVRELEGAFNRVGASSRFMNRPVIDIDLA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEHHHH
RTALQDIIAEKHKVITADIIIDAVAKYYRIKISDVLGKKRTRNIARPRQVAMSLTKELTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHH
LSLPSIGDSFGGRDHTTVMHGIRAVAKLREEDPELAQDYEKLLILIQN
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA