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The map label for this gene is obgE

Identifier: 161723237

GI number: 161723237

Start: 1629620

End: 1630927

Strand: Reverse

Name: obgE

Synonym: L0160

Alternate gene names: 161723237

Gene position: 1630927-1629620 (Counterclockwise)

Preceding gene: 15673570

Following gene: 15673568

Centisome position: 68.94

GC content: 39.83

Gene sequence:

>1308_bases
TTGTTTTTAGATACAGCACGAATTGAAGTAAAAGCTGGTAAAGGTGGCGATGGTGCAGTTGCTTTTCGCCGTGAAAAATA
TGTTCCAGATGGTGGTCCTGCCGGTGGTGACGGGGGAAAAGGCGGTTCTGTAATCTTTAAAGTTGATGAAGGAATGTCAA
CTTTGATGGATTTCCGTTATAACCGTATTTTCCGTGGTAAACCAGGTGAAAAAGGGATGAACAAAGGAATGCACGGTCGT
GGAGCCGAAGATTTGATTGTTCATGTTCCTCAAGGAACAACTGTTAAAGATAACGAAACTGGTGATGTTTTAGTTGACTT
AATCGAAAAAGACCAAGAATTTGCGGTTGCTAAAGGCGGTCGCGGCGGTCGTGGAAATATTCGCTTTGCCACACCACGTA
ACCCAGCACCTGAGGTAGCAGAAAATGGAGAACCAGGAGAAGATAAAATTCTACTTTTGGAACTTCGTGTTTTAGCAGAT
GTTGGTTTAGTTGGTTTTCCATCTGTTGGTAAATCAACATTATTGTCAGTTGTTTCAAATGCGCGTCCTAAAATTGGCGC
TTACCATTTCACAACAATCACTCCTAATATTGGAATGGTTCAAGTAGGTTATGGAGATAGTTTTGTTATGGCAGATATGC
CAGGATTGATTGAAGGAGCGCACTCTGGTGCAGGACTGGGAATTCAATTCTTGCGTCATATTGAACGTACACGTGTCCTT
CTTCATGTTCTTGATATGTCAGAACTTGAAGGACGAGATCCATACGAAGATTACAAAACAATCAATGATGAATTAGAATC
TTACAATTTACGTTTGATGGAACGTCCACAAATTATTGTTGCCAACAAAATGGATATGCCAGAAGCTGCCGAACGTTTAG
CTGAATTTAAAGAAAAATTAGCTGCTGATTTAGGTCCTGATAAAGAAATGCCTGAAATTTTTGAAGTTTCTGGCCTGACT
AAAACAGGACTTCAAGGTTTGCTTGCACGCACAAGTGAATTACTTGCACAAACACCAGAATTCTTACTTTACGATGAAGA
TGAATTAGCGGATGAAACAGCTTATTACGGCTTTGAAGAAGAAGAAAAACCATTTAAAGTTTCTCGTGATGATGATGGTG
GATGGCGCTTATCTGGGGATAAGATTGAAAGACTCTTTATCATGACTAATTTTGATCATGATGAATCAGTTATGAAATTT
GCTCGCCAAATGCGCGCGATGGGTGTTGACGAAACACTTCGTTCAATGGGAGCCAAGGATGGCGATTACGTTAGAATTCA
AAAATTTGAATTTGAATTTGTAGATTAA

Upstream 100 bases:

>100_bases
AAAAAAAGCTGATAAAATGCTATAATAGATAGCACGCATTTTTGTGGAAAAATAATAAATAAACTATATAAAGAAAATTT
AGAGGAGAAACTGTATGTCT

Downstream 100 bases:

>100_bases
AAATTTCAATATTTTCGGAGATTAAAAATGGGATTTAAAATTATTGGTGACCGTGACAAAGACGGAAATTTTATTGCCTC
AGCCGATTATTGGACCGATG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMHGR
GAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFAVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLAD
VGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRVL
LHVLDMSELEGRDPYEDYKTINDELESYNLRLMERPQIIVANKMDMPEAAERLAEFKEKLAADLGPDKEMPEIFEVSGLT
KTGLQGLLARTSELLAQTPEFLLYDEDELADETAYYGFEEEEKPFKVSRDDDGGWRLSGDKIERLFIMTNFDHDESVMKF
ARQMRAMGVDETLRSMGAKDGDYVRIQKFEFEFVD

Sequences:

>Translated_435_residues
MFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMHGR
GAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFAVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLAD
VGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRVL
LHVLDMSELEGRDPYEDYKTINDELESYNLRLMERPQIIVANKMDMPEAAERLAEFKEKLAADLGPDKEMPEIFEVSGLT
KTGLQGLLARTSELLAQTPEFLLYDEDELADETAYYGFEEEEKPFKVSRDDDGGWRLSGDKIERLFIMTNFDHDESVMKF
ARQMRAMGVDETLRSMGAKDGDYVRIQKFEFEFVD
>Mature_435_residues
MFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRYNRIFRGKPGEKGMNKGMHGR
GAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFAVAKGGRGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLAD
VGLVGFPSVGKSTLLSVVSNARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRVL
LHVLDMSELEGRDPYEDYKTINDELESYNLRLMERPQIIVANKMDMPEAAERLAEFKEKLAADLGPDKEMPEIFEVSGLT
KTGLQGLLARTSELLAQTPEFLLYDEDELADETAYYGFEEEEKPFKVSRDDDGGWRLSGDKIERLFIMTNFDHDESVMKF
ARQMRAMGVDETLRSMGAKDGDYVRIQKFEFEFVD

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=327, Percent_Identity=42.2018348623853, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI111955139, Length=288, Percent_Identity=34.7222222222222, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI111955063, Length=248, Percent_Identity=33.4677419354839, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI4758796, Length=127, Percent_Identity=39.3700787401575, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI4557537, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1789574, Length=339, Percent_Identity=45.4277286135693, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1787454, Length=138, Percent_Identity=32.6086956521739, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790615, Length=187, Percent_Identity=27.807486631016, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17508313, Length=333, Percent_Identity=40.2402402402402, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17552324, Length=336, Percent_Identity=28.5714285714286, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17555344, Length=118, Percent_Identity=38.135593220339, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71981008, Length=118, Percent_Identity=35.5932203389831, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17509631, Length=140, Percent_Identity=31.4285714285714, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=174, Percent_Identity=40.2298850574713, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319281, Length=126, Percent_Identity=36.5079365079365, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321649, Length=141, Percent_Identity=34.0425531914894, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321612, Length=126, Percent_Identity=34.9206349206349, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129375, Length=300, Percent_Identity=42, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24585318, Length=373, Percent_Identity=34.8525469168901, Blast_Score=168, Evalue=7e-42,
Organism=Drosophila melanogaster, GI17981711, Length=127, Percent_Identity=37.7952755905512, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356473, Length=126, Percent_Identity=36.5079365079365, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR015349
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF09269 DUF1967; PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 48034; Mature: 48034

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRY
CCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
NRIFRGKPGEKGMNKGMHGRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFAVAKGG
HHEECCCCCCHHHCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCCEEEECCC
RGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLADVGLVGFPSVGKSTLLSVVSN
CCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCHHHHHHHHHC
ARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRVL
CCCCCCEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
LHVLDMSELEGRDPYEDYKTINDELESYNLRLMERPQIIVANKMDMPEAAERLAEFKEKL
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
AADLGPDKEMPEIFEVSGLTKTGLQGLLARTSELLAQTPEFLLYDEDELADETAYYGFEE
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHCCCCC
EEKPFKVSRDDDGGWRLSGDKIERLFIMTNFDHDESVMKFARQMRAMGVDETLRSMGAKD
CCCCCEECCCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
GDYVRIQKFEFEFVD
CCEEEEEEEEEEECC
>Mature Secondary Structure
MFLDTARIEVKAGKGGDGAVAFRREKYVPDGGPAGGDGGKGGSVIFKVDEGMSTLMDFRY
CCCCCEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHH
NRIFRGKPGEKGMNKGMHGRGAEDLIVHVPQGTTVKDNETGDVLVDLIEKDQEFAVAKGG
HHEECCCCCCHHHCCCCCCCCCCCEEEECCCCCEECCCCCCHHHHHHHHCCCCEEEECCC
RGGRGNIRFATPRNPAPEVAENGEPGEDKILLLELRVLADVGLVGFPSVGKSTLLSVVSN
CCCCCCEEEECCCCCCCHHHCCCCCCCCCEEEEEEEHHHHCCCCCCCCCCHHHHHHHHHC
ARPKIGAYHFTTITPNIGMVQVGYGDSFVMADMPGLIEGAHSGAGLGIQFLRHIERTRVL
CCCCCCEEEEEEECCCCCEEEECCCCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHH
LHVLDMSELEGRDPYEDYKTINDELESYNLRLMERPQIIVANKMDMPEAAERLAEFKEKL
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHH
AADLGPDKEMPEIFEVSGLTKTGLQGLLARTSELLAQTPEFLLYDEDELADETAYYGFEE
HHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHCCHHHHCCCCC
EEKPFKVSRDDDGGWRLSGDKIERLFIMTNFDHDESVMKFARQMRAMGVDETLRSMGAKD
CCCCCEECCCCCCCEEECCCCEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHCCCCC
GDYVRIQKFEFEFVD
CCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]