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The map label for this gene is tyrS [H]

Identifier: 161723158

GI number: 161723158

Start: 1388176

End: 1389417

Strand: Direct

Name: tyrS [H]

Synonym: BTH_I1240

Alternate gene names: 161723158

Gene position: 1388176-1389417 (Clockwise)

Preceding gene: 83719272

Following gene: 83720501

Centisome position: 36.44

GC content: 64.98

Gene sequence:

>1242_bases
ATGAGCACCGATCCCACTTCCAAGCCCGCCTTCCCGATCACCGATGAAATCCGCCATGCGCTCGCCGTCACGAAGCGCGG
CGTCGACGAGCTGCTGATCGAGGAAGAGTTCGCGCAGAAGCTCGCGAGAAGCGCGGCGACGGGCAAGCCGCTGCGCATCA
AGCTGGGCCTCGATCCGACGGCGCCCGACATCCACCTCGGCCACACGGTCGTGCTGAACAAGATGCGCCAGCTGCAGGAT
CTCGGCCATACGGTGATCTTCCTGATCGGCGATTTCACGTCGCTGATCGGCGATCCGTCGGGCCGCAACGCGACGCGGCC
GCCGCTCACGCGCGAGCAGATCGAATCGAACGCGAAGACCTACTTCGAGCAGGCCGCGCTCGTGCTCGATCGCGAGAAGA
CCGAGATCCGCTACAACAGCGAATGGTCGATGCCGCTCGGCGCGGACGGGATGATCAAGCTCGCGTCGCGCTACACGGTC
GCGCGGATGCTCGAGCGCGAGGATTTCACGAAGCGATTCCAGGGCGGCATCCCGATCTCGATCCACGAATTCCTGTATCC
GCTGATGCAAGGCTACGACTCGGTCGCGCTGAACGCCGATCTCGAGCTAGGCGGCACCGACCAGAAATTCAACCTGCTCG
TCGGCCGCGAGCTGCAGAAGCAGTACGGGCAGGAGCAGCAGTGCATCCTGACGATGCCGCTGCTCGAAGGCCTCGACGGC
GTCGAGAAGATGTCGAAATCGAAGGGCAACTACGTCGGCATCGGCGAGAAGCCGAACGACATGTTCGGCAAGCTGATGAG
CATCTCGGACGTGCTGATGTGGCGCTACTTCGAGCTTCTGTCGTTCCGCAGCCTCGACGAGATCGCGCGGCTGCGCGGCG
AGGCCGAGGGCGGGCGCAACCCGCGAGACTTCAAGGTGATGCTCGCGCAGGAGATCGTCGCGCGCTTTCATTCGCAGGCC
GATGCCGAACGCGCGCTCGAGGATTTCAATCACCGTGCGAAGGGTGGCGTACCCGACGACATCCCGACCGTGACGCTCGC
AGGCGCGCCGCTTGCGATCGGCCAGTTGCTGAAGCAGGCGGGGCTCGTGCCGTCGACGAGCGAGGCGCTGCGCAACATCG
AGCAGGGCGGCGTGAAGATCGACGGCGCGACGGTGTCCGACAAGGCGCTGAAGGTTGACGCGGGCGAATTCGTCGTGCAG
GTCGGCAAGCGCCGCTTCGCGCGCGTGACGCTCACCGCATGA

Upstream 100 bases:

>100_bases
TTGCCGCCGATTATCCGCGCAAGCGCGCGCGCCGTTAAGCGGCTCGCGCACAACTTATGGGAAAATCGCTCTTTTTGCGA
CATTCCTTCCTCTTGCACCG

Downstream 100 bases:

>100_bases
GCGCGCGCATCGCCGCTTGGCCGGGCATGCCGCGCGCCGCGCGCGGCATGCATCGCGGCCGCGCCGCGCACGTGACGCTG
GCGCACGCATGATCGCATTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSTDPTSKPAFPITDEIRHALAVTKRGVDELLIEEEFAQKLARSAATGKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGIGEKPNDMFGKLMSISDVLMWRYFELLSFRSLDEIARLRGEAEGGRNPRDFKVMLAQEIVARFHSQA
DAERALEDFNHRAKGGVPDDIPTVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQ
VGKRRFARVTLTA

Sequences:

>Translated_413_residues
MSTDPTSKPAFPITDEIRHALAVTKRGVDELLIEEEFAQKLARSAATGKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQD
LGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTV
ARMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
VEKMSKSKGNYVGIGEKPNDMFGKLMSISDVLMWRYFELLSFRSLDEIARLRGEAEGGRNPRDFKVMLAQEIVARFHSQA
DAERALEDFNHRAKGGVPDDIPTVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQ
VGKRRFARVTLTA
>Mature_412_residues
STDPTSKPAFPITDEIRHALAVTKRGVDELLIEEEFAQKLARSAATGKPLRIKLGLDPTAPDIHLGHTVVLNKMRQLQDL
GHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKTYFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVA
RMLEREDFTKRFQGGIPISIHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDGV
EKMSKSKGNYVGIGEKPNDMFGKLMSISDVLMWRYFELLSFRSLDEIARLRGEAEGGRNPRDFKVMLAQEIVARFHSQAD
AERALEDFNHRAKGGVPDDIPTVTLAGAPLAIGQLLKQAGLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQV
GKRRFARVTLTA

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=401, Percent_Identity=26.1845386533666, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787925, Length=424, Percent_Identity=29.9528301886792, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI25145802, Length=210, Percent_Identity=29.5238095238095, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325160, Length=402, Percent_Identity=24.8756218905473, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20130383, Length=450, Percent_Identity=25.7777777777778, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 45682; Mature: 45551

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDPTSKPAFPITDEIRHALAVTKRGVDELLIEEEFAQKLARSAATGKPLRIKLGLDPT
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPIS
HHHHHHHHHCCCHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGIGEKPNDMFGKLMSISDVLMWRYFELLSFRSLDEIARLRGEAEGGRN
HHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPTVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA
CCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHHHHHHHHHEEEEEECC
>Mature Secondary Structure 
STDPTSKPAFPITDEIRHALAVTKRGVDELLIEEEFAQKLARSAATGKPLRIKLGLDPT
CCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCC
APDIHLGHTVVLNKMRQLQDLGHTVIFLIGDFTSLIGDPSGRNATRPPLTREQIESNAKT
CCCCCCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHH
YFEQAALVLDREKTEIRYNSEWSMPLGADGMIKLASRYTVARMLEREDFTKRFQGGIPIS
HHHHHHHHHCCCHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
IHEFLYPLMQGYDSVALNADLELGGTDQKFNLLVGRELQKQYGQEQQCILTMPLLEGLDG
HHHHHHHHHCCCCCEEEECCEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCHH
VEKMSKSKGNYVGIGEKPNDMFGKLMSISDVLMWRYFELLSFRSLDEIARLRGEAEGGRN
HHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
PRDFKVMLAQEIVARFHSQADAERALEDFNHRAKGGVPDDIPTVTLAGAPLAIGQLLKQA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHC
GLVPSTSEALRNIEQGGVKIDGATVSDKALKVDAGEFVVQVGKRRFARVTLTA
CCCCCHHHHHHHHHHCCEEECCCEECCCEEEECHHHHHHHHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA