BacMap

Definition	Bacillus anthracis str. Sterne chromosome, complete genome.
Accession	NC_005945
Length	5,228,663

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The map label for this gene is fabG [H]

Identifier: 161611177

GI number: 161611177

Start: 4431253

End: 4432044

Strand: Reverse

Name: fabG [H]

Synonym: BAS4522

Alternate gene names: 161611177

Gene position: 4432044-4431253 (Counterclockwise)

Preceding gene: 49187518

Following gene: 49187515

Centisome position: 84.76

GC content: 37.5

Gene sequence:

>792_bases
ATGAACTATAGCAATTTAAAAGGGGGCCGTTTTGTGAGACACGCGCTCATTACAGCCGGTACGAAAGGTTTAGGAAAGCA
AGTAACAGAGAAGTTATTGGCTAAAGGGTATTCAGTAACAGTAACGTATCATAGCGATATCACGGCTATGAAAAAGATGA
AAGAAACATATAAAAATATGGAAGAGCGTCTACAATTCGTGCAAGCGGATGTCACGAAAAAGGAAGATTTACATAAAATA
GTAGAAGAAGCGATAAGCCGTTTTGGCAAAATTGATTTCTTAATTAATAATGCTGGTCCATATGTATTTGAACGAAAAAA
GTTAGTCGATTATGAAGAAGATGAATGGAATGAAATGATTCAGGGTAATTTAACAGCTGTATTTCATTTGTTGAAGCTTG
TCGTTCCGATTATGAGAAAACAGAACTTTGGCCGTATTATTAATTACGGATTCCAAGGGGCAGATAGTGCACCGGGATGG
ATTTATCGTTCAGCTTTTGCAGCAGCGAAAGTAGGACTTGTTTCATTAACGAAAACTGTTGCTTACGAAGAAGCGGAATA
TGGAATTACTGCAAATATGGTATGTCCTGGTGATATTATTGGTGAAATGAAAGAAGCGACAATTCAAGAAGCACGTCAGT
TGAAAGAACGTAACACACCAATTGGTAGATCTGGAACAGGTGAAGATATCGCAAGAACGATTTCGTTTTTATGCGAGGAA
GATTCCGATATGATTACCGGTACAATTATTGAAGTAACTGGTGCAGTAGATGTTATTCATAGACATCGATAG

Upstream 100 bases:

>100_bases
AAAACAAATTTTGGTAATGTGCTTGCCAGAAACGTTACAGAATTTCGAAAACTCTGTTTTGATTCATTTTAGTTGTAATT
GGTGCGAGAACTTGTTACAT

Downstream 100 bases:

>100_bases
AGAAAAATAAAGTGAAGTTTCGAATGATTGGACAGTTTATCCTTTATGCTGATAGGTGCGGATAATACTGTCCTTTAATA
TAAAATTAAATCTATCGGAA

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MNYSNLKGGRFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR

Sequences:

>Translated_263_residues
MNYSNLKGGRFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR
>Mature_263_residues
MNYSNLKGGRFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNMEERLQFVQADVTKKEDLHKI
VEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMIQGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGW
IYRSAFAAAKVGLVSLTKTVAYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEE
DSDMITGTIIEVTGAVDVIHRHR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=248, Percent_Identity=26.2096774193548, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI32483357, Length=260, Percent_Identity=29.2307692307692, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI15277342, Length=250, Percent_Identity=28, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI59889578, Length=214, Percent_Identity=28.0373831775701, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI66933014, Length=208, Percent_Identity=30.2884615384615, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI126723750, Length=268, Percent_Identity=27.6119402985075, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=24.901185770751, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI31542939, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI4758504, Length=193, Percent_Identity=27.4611398963731, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=24.4897959183673, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=32.2314049586777, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788459, Length=241, Percent_Identity=30.2904564315353, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082160, Length=260, Percent_Identity=28.8461538461538, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=26.6932270916335, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=29.8804780876494, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=27.5303643724696, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=26.1904761904762, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI2367365, Length=240, Percent_Identity=25, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=24.7058823529412, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=22.9838709677419, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786812, Length=252, Percent_Identity=24.2063492063492, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=250, Percent_Identity=28.8, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.3233082706767, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI25147288, Length=263, Percent_Identity=26.9961977186312, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17562904, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=25.2918287937743, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=277, Percent_Identity=27.0758122743682, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17560676, Length=258, Percent_Identity=26.3565891472868, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551412, Length=270, Percent_Identity=27.4074074074074, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=30.8270676691729, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71994604, Length=258, Percent_Identity=23.6434108527132, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=25.6916996047431, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=24.904214559387, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=270, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=25.6505576208178, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=265, Percent_Identity=25.2830188679245, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17568967, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=273, Percent_Identity=26.7399267399267, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=25.7462686567164, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=244, Percent_Identity=25.4098360655738, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=25.6603773584906, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538486, Length=280, Percent_Identity=27.5, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=209, Percent_Identity=24.8803827751196, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508651, Length=254, Percent_Identity=27.1653543307087, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=25.2873563218391, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=126, Percent_Identity=36.5079365079365, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324126, Length=278, Percent_Identity=23.021582733813, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=28.3400809716599, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24644339, Length=246, Percent_Identity=27.2357723577236, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=26.5873015873016, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI18859837, Length=242, Percent_Identity=27.6859504132231, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=28.4584980237154, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=26.2096774193548, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=25.296442687747, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI28571526, Length=251, Percent_Identity=25.8964143426295, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 29535; Mature: 29535

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYSNLKGGRFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNM
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
EERLQFVQADVTKKEDLHKIVEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCHHHHHHHH
QGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEVTGAVDVIHRHR
CCCEEEEHHEEHHHHHHHHHCCC
>Mature Secondary Structure
MNYSNLKGGRFVRHALITAGTKGLGKQVTEKLLAKGYSVTVTYHSDITAMKKMKETYKNM
CCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHH
EERLQFVQADVTKKEDLHKIVEEAISRFGKIDFLINNAGPYVFERKKLVDYEEDEWNEMI
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHCCCCHHHHHHHH
QGNLTAVFHLLKLVVPIMRKQNFGRIINYGFQGADSAPGWIYRSAFAAAKVGLVSLTKTV
HCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
AYEEAEYGITANMVCPGDIIGEMKEATIQEARQLKERNTPIGRSGTGEDIARTISFLCEE
HHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
DSDMITGTIIEVTGAVDVIHRHR
CCCEEEEHHEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]