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The map label for this gene is groEL [H]

Identifier: 161525697

GI number: 161525697

Start: 2746603

End: 2748243

Strand: Reverse

Name: groEL [H]

Synonym: Bmul_2528

Alternate gene names: 161525697

Gene position: 2748243-2746603 (Counterclockwise)

Preceding gene: 161525698

Following gene: 161525695

Centisome position: 79.69

GC content: 62.95

Gene sequence:

>1641_bases
ATGGCAGCTAAAGACGTCGTATTCGGCGATTCGGCCCGTGCGAAGATGGTCGAAGGCGTGAACATTCTCGCCAACGCAGT
GAAGGTCACGCTGGGTCCGAAGGGCCGCAACGTCGTGCTCGAGCGCAGCTTCGGCGGCCCGACGGTCACGAAGGACGGTG
TGTCGGTCGCGAAGGAAATCGAGCTGAAGGACAAGCTCCAGAACATGGGCGCGCAAATGGTCAAGGAAGTTGCTTCCAAG
ACCAGCGACAACGCAGGCGACGGCACGACGACGGCAACCGTCCTCGCGCAATCGATCGTCCGCGAAGGCATGAAGTACGT
CGCATCGGGCATGAACCCGATGGACCTGAAGCGCGGTATCGACAAGGCCGTTGCAGCTGCCGTCGAAGAGCTGAAGAAGA
TCAGCAAGCCGTGCACGACGAACAAGGAAATCGCGCAAGTCGGCGCGATCTCGGCGAACAGCGACTCGTCGATCGGCGAT
CGCATCGCTGAAGCGATGGACAAGGTCGGCAAGGAAGGCGTGATCACCGTCGAAGACGGCAAGTCGCTCGCCGATGAGCT
CGACGTCGTCGAAGGCATGCAGTTCGACCGCGGCTACCTGTCGCCGTACTTCATCAACAACCCGGACAAGCAAGTCGCCG
TCCTCGAGAACCCGTTCGTGCTGCTGCACGACAAGAAGGTCTCGAACATCCGCGATCTGCTGCCGGTGCTCGAACAAGTC
GCGAAGGCAGGCCGTCCGCTGCTGATCATCGCTGAAGACGTCGAAGGCGAAGCGCTCGCTACGCTGGTCGTCAACAACAT
CCGCGGCATCCTGAAGACCGTTGCGGTCAAGGCGCCGGGCTTCGGCGATCGTCGCAAGGCGATGCTGGAAGACATCGCGA
TCCTGACCGGCGGCCAGGTCATCGCGGAAGAAACCGGCCTGACGCTCGAGAAGGCAACGCTGGCAGAACTGGGCCAGGCG
AAGCGCATCGAAGTGGGCAAGGAAAACACGACGATCATCGACGGTGCAGGCGAAGCGGCGAACATCGAAGCGCGCGTCAA
GCAAATCCGCACGCAGATCGAAGAAGCGACGTCGGACTACGACCGCGAGAAGCTGCAAGAGCGCGTGGCGAAGCTGGCCG
GCGGCGTGGCAGTGATCAAGGTCGGTGCTGCGACCGAAGTCGAAATGAAGGAAAAGAAGGCACGTGTCGAAGACGCGCTG
CACGCAACCCGCGCTGCCGTTGAAGAAGGCATCGTCCCGGGCGGCGGCGTTGCGCTGATCCGTGCACGCACCGCGATCGC
ATCGCTGACGGGCGCGAACGCTGACCAAAACGCCGGCATCAAGATCGTGCTGCGCGCAATGGAAGAGCCGCTGCGTCAGA
TCGTCACGAACGGTGGCGAAGAAGCGAGCGTCGTCGTGGCGGCCGTTGCTGCAGGCAAGGGCAACTACGGCTACAACGCA
GCGACGGGCGAGTACGTCGACATGGTCGAAGCCGGCGTCGTCGACCCGACCAAGGTCACGCGCACCGCACTGCAGAACGC
AGCGTCGGTTGCCGGCCTGCTGCTGACGACGGACGCAGCCGTCGCAGAACTGCCGAAGGAAGATGCACCGATGCCGGGCG
GCATGCCGGGCGGCATGGGCGGCATGGGCATGGACATGTAA

Upstream 100 bases:

>100_bases
GGAGCTGCTGGTCATGCGCGAAGAAGACATCATGGCCGTGGTCAACGCGAAGTAAGCGTCCACAACGGTACATATTCCCA
AGAATTCAAGGAGTTAGAAG

Downstream 100 bases:

>100_bases
TCGACTTCGGTCGATGAAGTCCGGAGCGCGCAGCGATGCGTACTCCAGCCAAATAAAGAGACCCGCAGCGATGCGGGTCT
TTTTTTATCTGCGCGCGGCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIASLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Sequences:

>Translated_546_residues
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASK
TSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGD
RIAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQA
KRIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGIVPGGGVALIRARTAIASLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM
>Mature_545_residues
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEIELKDKLQNMGAQMVKEVASKT
SDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGIDKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDR
IAEAMDKVGKEGVITVEDGKSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQVA
KAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQVIAEETGLTLEKATLAELGQAK
RIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGIVPGGGVALIRARTAIASLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNAA
TGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMGGMGMDM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=54.3560606060606, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=54.3560606060606, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI24307939, Length=350, Percent_Identity=23.7142857142857, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI5453607, Length=553, Percent_Identity=22.7848101265823, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=76.1814744801512, Blast_Score=800, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.1190926275992, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=218, Percent_Identity=52.2935779816514, Blast_Score=222, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI25144674, Length=548, Percent_Identity=22.2627737226277, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=35.1145038167939, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=52.4714828897338, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6322446, Length=582, Percent_Identity=21.6494845360825, Blast_Score=73, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=375, Percent_Identity=24.2666666666667, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322350, Length=567, Percent_Identity=22.5749559082892, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.1821631878558, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.1821631878558, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=51.0436432637571, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=51.0436432637571, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=51.0436432637571, Blast_Score=541, Evalue=1e-154,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=44, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=37.3106060606061, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=37.3106060606061, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI17647245, Length=574, Percent_Identity=23.1707317073171, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652903, Length=547, Percent_Identity=23.5831809872029, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57090; Mature: 56959

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIASLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC
>Mature Secondary Structure 
AAKDVVFGDSARAKMVEGVNILANAVKVTLGPKGRNVVLERSFGGPTVTKDGVSVAKEI
CCCCCEECCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCHHHHHHHH
ELKDKLQNMGAQMVKEVASKTSDNAGDGTTTATVLAQSIVREGMKYVASGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVAAAVEELKKISKPCTTNKEIAQVGAISANSDSSIGDRIAEAMDKVGKEGVITVEDG
HHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
KSLADELDVVEGMQFDRGYLSPYFINNPDKQVAVLENPFVLLHDKKVSNIRDLLPVLEQV
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGRPLLIIAEDVEGEALATLVVNNIRGILKTVAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEE
IAEETGLTLEKATLAELGQAKRIEVGKENTTIIDGAGEAANIEARVKQIRTQIEEATSDY
EECCCCCEEHHHHHHHCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGIVPGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEH
RARTAIASLTGANADQNAGIKIVLRAMEEPLRQIVTNGGEEASVVVAAVAAGKGNYGYNA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
ATGEYVDMVEAGVVDPTKVTRTALQNAASVAGLLLTTDAAVAELPKEDAPMPGGMPGGMG
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCC
GMGMDM
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA