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The map label for this gene is map [H]

Identifier: 161525326

GI number: 161525326

Start: 2372573

End: 2373379

Strand: Reverse

Name: map [H]

Synonym: Bmul_2156

Alternate gene names: 161525326

Gene position: 2373379-2372573 (Counterclockwise)

Preceding gene: 161525327

Following gene: 161525323

Centisome position: 68.82

GC content: 67.66

Gene sequence:

>807_bases
ATGGCGAAGCGCGAAATCCCGATCCGCAACCCGCAAGACATCGCCAAGTCGCGCGAGGCGGCGAAGCTCGCGTCGCAGGT
GCTGACGATGATCGGCGAATATGTGAAGCCGGGCGTCACGACCGACGAACTGGACGAACGCTGCCGCCGCTATATCGTCG
ACGAACTCGGCGCGATTCCGGCCAACATCGGCTATCACGGCTATCCGAAGACGGTCTGCGCGTCGGTCAATCACGTCGTC
TGCCACGGCATTCCGTCGTCGCGGCCGCTGCGCGACGGCGACATCGTGAACCTCGACATCGCGGTGATCAAGGACGGCTG
GTTCGGCGACACGAGCCGCATGTACTTCGTCGGCGAGCCGGGCGAGCTGGCGCGCCGCCTCGTCGCGACGACGTACGAGG
CGATGCATGCGGGCATCCGCGCGGTGCGGCCGGGCGCGACGCTCGGCGACGTCGGCTATGCGATCCAGCAGGTCGCACAT
CGCGAAGGGTTCAGCGTCGTGCGCGAATACTGCGGGCACGGCATCGGCGACGTGTATCACGACGAGCCGCAAGTGCTGCA
CTACGGCCGCCCCGGCACAGGGCTGCCGCTGCGGCCGGGCATGATCTTCACGATCGAGCCGATGCTCAACGCAGGCAAGC
GCGACACGCGCGTGCTCGGCGACGGCTGGACCGTCGTCACGAAGGACCATTCGCTGTCCGCCCAATGGGAGCACATGGTG
GTCGTGACGGAGCAGGGCTACGAAGTGCTGACCGACGACGTGGGGCCGCCCGCGTTCGCCGAACTGCCCGGCACGCGCGT
CGCCTGA

Upstream 100 bases:

>100_bases
CGTCCTACGGCGACATCTGCCGGATGCTGATCGAGGCGGAGGCGCGCGGCGGTACGGGCGCGGCCGAGCCGGTCGCCGGC
CGCATCGAGCAGGTGGCGTA

Downstream 100 bases:

>100_bases
CGGGCGCCGCACGCCGCGGGCGGCTTCGAAGTCGCCGCCGGCATTGAACCGAAGTGAAACGGGCCCGATGCGATCGGGCC
CGTTTCGTTTGGCGGCGCGC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MAKREIPIRNPQDIAKSREAAKLASQVLTMIGEYVKPGVTTDELDERCRRYIVDELGAIPANIGYHGYPKTVCASVNHVV
CHGIPSSRPLRDGDIVNLDIAVIKDGWFGDTSRMYFVGEPGELARRLVATTYEAMHAGIRAVRPGATLGDVGYAIQQVAH
REGFSVVREYCGHGIGDVYHDEPQVLHYGRPGTGLPLRPGMIFTIEPMLNAGKRDTRVLGDGWTVVTKDHSLSAQWEHMV
VVTEQGYEVLTDDVGPPAFAELPGTRVA

Sequences:

>Translated_268_residues
MAKREIPIRNPQDIAKSREAAKLASQVLTMIGEYVKPGVTTDELDERCRRYIVDELGAIPANIGYHGYPKTVCASVNHVV
CHGIPSSRPLRDGDIVNLDIAVIKDGWFGDTSRMYFVGEPGELARRLVATTYEAMHAGIRAVRPGATLGDVGYAIQQVAH
REGFSVVREYCGHGIGDVYHDEPQVLHYGRPGTGLPLRPGMIFTIEPMLNAGKRDTRVLGDGWTVVTKDHSLSAQWEHMV
VVTEQGYEVLTDDVGPPAFAELPGTRVA
>Mature_267_residues
AKREIPIRNPQDIAKSREAAKLASQVLTMIGEYVKPGVTTDELDERCRRYIVDELGAIPANIGYHGYPKTVCASVNHVVC
HGIPSSRPLRDGDIVNLDIAVIKDGWFGDTSRMYFVGEPGELARRLVATTYEAMHAGIRAVRPGATLGDVGYAIQQVAHR
EGFSVVREYCGHGIGDVYHDEPQVLHYGRPGTGLPLRPGMIFTIEPMLNAGKRDTRVLGDGWTVVTKDHSLSAQWEHMVV
VTEQGYEVLTDDVGPPAFAELPGTRVA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=257, Percent_Identity=42.8015564202335, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI40385867, Length=246, Percent_Identity=41.4634146341463, Blast_Score=212, Evalue=3e-55,
Organism=Escherichia coli, GI1786364, Length=259, Percent_Identity=56.7567567567568, Blast_Score=306, Evalue=8e-85,
Organism=Escherichia coli, GI1788728, Length=250, Percent_Identity=25.6, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789275, Length=275, Percent_Identity=25.4545454545455, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=38.6454183266932, Blast_Score=190, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6323273, Length=249, Percent_Identity=41.3654618473896, Blast_Score=213, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355531, Length=260, Percent_Identity=40.3846153846154, Blast_Score=203, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=37.3983739837398, Blast_Score=183, Evalue=1e-46,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29359; Mature: 29228

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKREIPIRNPQDIAKSREAAKLASQVLTMIGEYVKPGVTTDELDERCRRYIVDELGAIP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
ANIGYHGYPKTVCASVNHVVCHGIPSSRPLRDGDIVNLDIAVIKDGWFGDTSRMYFVGEP
CCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCC
GELARRLVATTYEAMHAGIRAVRPGATLGDVGYAIQQVAHREGFSVVREYCGHGIGDVYH
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DEPQVLHYGRPGTGLPLRPGMIFTIEPMLNAGKRDTRVLGDGWTVVTKDHSLSAQWEHMV
CCCCEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCEEECCCEEEEEECCCCCCCEEEEE
VVTEQGYEVLTDDVGPPAFAELPGTRVA
EEECCCCEEECCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
AKREIPIRNPQDIAKSREAAKLASQVLTMIGEYVKPGVTTDELDERCRRYIVDELGAIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
ANIGYHGYPKTVCASVNHVVCHGIPSSRPLRDGDIVNLDIAVIKDGWFGDTSRMYFVGEP
CCCCCCCCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEEEEECCCCCCCCEEEEECCC
GELARRLVATTYEAMHAGIRAVRPGATLGDVGYAIQQVAHREGFSVVREYCGHGIGDVYH
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DEPQVLHYGRPGTGLPLRPGMIFTIEPMLNAGKRDTRVLGDGWTVVTKDHSLSAQWEHMV
CCCCEEEECCCCCCCCCCCCEEEEECHHHCCCCCCCEEECCCEEEEEECCCCCCCEEEEE
VVTEQGYEVLTDDVGPPAFAELPGTRVA
EEECCCCEEECCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]