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The map label for this gene is hisQ [H]

Identifier: 161525299

GI number: 161525299

Start: 2342700

End: 2343482

Strand: Reverse

Name: hisQ [H]

Synonym: Bmul_2129

Alternate gene names: 161525299

Gene position: 2343482-2342700 (Counterclockwise)

Preceding gene: 161525300

Following gene: 161525298

Centisome position: 67.96

GC content: 63.22

Gene sequence:

>783_bases
TTGAGGCAATCAATTTCGCTTGCGACTATCCGCGTCAGCACGGTGCGGGAAGGGATTCGCGCCGGCATTGATTCCAAGAT
CCAGGAGACGCGCGTGTTCCTTTACGGCTTTGGTCCCGTCCTGTGGGCCGGCACCGTGCAGACCATCGAGCTGTCGGTGC
TGTCGCTCGCCACTGCGGTGGCGCTGGGGCTGATCGGCGCGGTGGCGAAGCTGTCGCACAATCGGGTGCTGCGAGCGATC
GCGACCGGTTATACGACGCTGATTCGCTCGGTGCCCGATCTCGTTCTGATGTTGCTGCTGTTCTACAGCATCCAGATCTG
GCTGAACCAGTTCACCGACCTGGTCGGCTGGACCCAGATCGACATCGATCCGTTCGTCGCGGGCGTGCTGACGCTCGGCT
TCATCTACGGCGCGTACTTCACCGAAACGTTCCGCGGCGCGTTCCTCGCGGTGCCGCGCGGCCAGCTCGAGGCGGGCGCC
GCCTACGGGATGAGCGGGGCGCGCGTGTTCGTGCGGATCCTGTTTCCGCAGATGATGCGCTTTGCGCTGCCGGGGATCGG
CAACAACTGGCAGGTGCTCGTGAAGGCGACCGCGCTGGTGTCGATCATCGGCCTCGCGGACGTCGTGAAGGCCGCGCAGG
ACGCCGGCAAGAGCACGTTCAACATGTTCTTCTTCATCCTCGTCGCGGCGCTGATCTATCTCGCGATCACGACCGTTTCC
AACCTCGTGCTGATCCAGCTCGAGAAGCGTTATTCCATGGGCGTGCGGCACGCAGAACTATGA

Upstream 100 bases:

>100_bases
TGTCAGGAAGCGGCTTTTTTCCTTTTGAAACAGCGGGATAGGCAGCGCGCGCAAACCGGCTGCGGAATTGCTGCGATGCA
GCAAGCGTGCGCAGGGTGAT

Downstream 100 bases:

>100_bases
TCGAGATCCTTCAGGAATTCGGCAAGGCGTTCCTTTACTGGGACGGCCAGCGCCTCTCCGGCCTTGCGGTGACGCTGTGG
CTGCTCGTTGCGTCGATTTC

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MRQSISLATIRVSTVREGIRAGIDSKIQETRVFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAI
ATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLVGWTQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGA
AYGMSGARVFVRILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVS
NLVLIQLEKRYSMGVRHAEL

Sequences:

>Translated_260_residues
MRQSISLATIRVSTVREGIRAGIDSKIQETRVFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAI
ATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLVGWTQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGA
AYGMSGARVFVRILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVS
NLVLIQLEKRYSMGVRHAEL
>Mature_260_residues
MRQSISLATIRVSTVREGIRAGIDSKIQETRVFLYGFGPVLWAGTVQTIELSVLSLATAVALGLIGAVAKLSHNRVLRAI
ATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLVGWTQIDIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGA
AYGMSGARVFVRILFPQMMRFALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVS
NLVLIQLEKRYSMGVRHAEL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=227, Percent_Identity=62.9955947136564, Blast_Score=285, Evalue=2e-78,
Organism=Escherichia coli, GI1787087, Length=216, Percent_Identity=37.037037037037, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1787030, Length=215, Percent_Identity=31.1627906976744, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788226, Length=221, Percent_Identity=29.4117647058824, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788645, Length=229, Percent_Identity=31.4410480349345, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786874, Length=181, Percent_Identity=30.3867403314917, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=27.8301886792453, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082239, Length=220, Percent_Identity=26.3636363636364, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787086, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 28384; Mature: 28384

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQSISLATIRVSTVREGIRAGIDSKIQETRVFLYGFGPVLWAGTVQTIELSVLSLATAV
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHHHHH
ALGLIGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLVGWTQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
DIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMSGARVFVRILFPQMMR
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHH
FALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NLVLIQLEKRYSMGVRHAEL
HHHEEEEHHHHHCCCCCCCC
>Mature Secondary Structure
MRQSISLATIRVSTVREGIRAGIDSKIQETRVFLYGFGPVLWAGTVQTIELSVLSLATAV
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHEEEEEECCHHHHHCCHHHHHHHHHHHHHHH
ALGLIGAVAKLSHNRVLRAIATGYTTLIRSVPDLVLMLLLFYSIQIWLNQFTDLVGWTQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
DIDPFVAGVLTLGFIYGAYFTETFRGAFLAVPRGQLEAGAAYGMSGARVFVRILFPQMMR
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCHHCCCCHHHHHHHHHHHHHHH
FALPGIGNNWQVLVKATALVSIIGLADVVKAAQDAGKSTFNMFFFILVAALIYLAITTVS
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
NLVLIQLEKRYSMGVRHAEL
HHHEEEEHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]