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The map label for this gene is yjcE [H]

Identifier: 161525088

GI number: 161525088

Start: 2095521

End: 2097101

Strand: Direct

Name: yjcE [H]

Synonym: Bmul_1916

Alternate gene names: 161525088

Gene position: 2095521-2097101 (Clockwise)

Preceding gene: 161525087

Following gene: 161525089

Centisome position: 60.77

GC content: 71.22

Gene sequence:

>1581_bases
ATGAGCAACGTCGAACTGTTCCATTACCTGCTGCTGTTGATCTGCGGCGCCGGCGCGCTGACGTGGCTCGCGGAGCGACT
GTCGATTCCGCCCGCCGTCGTGCTGCTGCTCGGCGGCTGCGTCGTCGCGGTCGCCGGCAAGCGCGTGCCCGACATGGACC
CGGCACTGCTGCTCGCGGCCGTGCTGCCGCCGCTGCTGATGTCGAGCGGCTTCTATACCGCGTGGAAGGCGTTCCGCCAC
GAGCTCGCGTCGATCGCCTCGCTCGCGCTCGGTGCCGTCGTGTTTACGACGGTCGCGGTCGCGCTCGCCGTGCATGCGTT
CAACCCGGCGCTGCCGTGGGCCGCGTGCTTCACGCTCGGCGCGATCGTGTCGCCGCCCGACGCGGTCGCCGCGAAGGCGA
TCCTGCAACGCCATCCGCTGCCCGCGCGGCTCGTCGCCGTGCTCGAAGGCGAAAGCCTCGTCAACGATGCGTCGGGCCTG
CTGCTGTATCAGATCGCCGTGTCGGCCGCGCTCGCGGTGACCATCACGACCGCGAGCGCGGCCGGCCTGTTCCTGTCGCT
CACGCTGATCGGCATCGCGGTCGGCTTCGCGTGCGGCCAGGCGATGTGCTGGGTGCTGCAGCGGCTGCGCGAGCCGATGC
TCGGCATCGTCGTGACGTTCGCGATGGCGTGGGGCAGCTACGGCATCGCGGAAGCGCTGCACGGCTCGGGCGTGCTGTCG
GTCGTGAGCTGCGGGCTCGTGCTCGGCGTACGGCAGCATCGCGTATTCGACGCCGACATGCGGATCAAGGCGAAGGCGAC
CTGGGAAGCGATCGTCTTCGTGCTCGATGCGCTCGTGTTCATCCTGATCGGCCTCGCGCTGCACGCGATCCTGGCCGGCG
TCAACCGCGAAGGCGCCGTGCTGATGGCCGGATTGCGCGTCGCGCTGCCGGCCACCGCGGCCGCGATCGTCGCGCGCATC
GCCTGGGTGTTCGTCGCGATGTGGCTGCCGGGGCGCCTGCGCGCGCCGCGTGCAGGCCATGCGCCGTGGTCGTGGCGGGA
AGCCGTCGTGCTCGGCTGGTCCGGCATGCGCGGCGTCGTCAGCCTCGCCGCCGCGATCGCGCTGCCGGCCGGTTTTCCGG
GCCGCGACCTGATCCTGTTCAGCACGTTCCTGCTGATCATCGCGACGCTCGTCGTGCAGGGCGGCACGCTCGCCCCGCTG
ATCCGCGCGCTGAAGCTGCAGCCGGCCGCGCGCCACACGATGTCCGAGCATGCGGTGCGCGCCCACACGTTCGGCGCGGC
GCTCGCGGCGCTCGATGCGCGCGGGCAGCACGGCACGCAGCTCGAGCGCGCTTCGCTCGAGCGGCTCTTGACCGAATACC
GCAACCGCGTCGCCTTCAACGAGCGCGCGTACCGCGAAGGCGCCGAACCGGCGGACGTGCGCGCGCGGATGCTGCGCGTC
GAGCTCGAACTGGTCGGCGTGTCGCGCGATGCGTTGCTCGCGCTGCATCGCGACGGCCGCGTCGACGATGCGGTGCTGCA
CCGCATAGAATCCGAGCTGGACTTCGAGGAGCTGCGGCTGCAGCGCCTGCTCGAACCGTAA

Upstream 100 bases:

>100_bases
GTCGGCCTGTTCGGCAGACTGCCCGGCGAACCGGTACTGCCGGCCAGCCGCACCCACGCGCGCAAACCATCGTGATGCGG
CACGTCGCGAGCCGCCGCCG

Downstream 100 bases:

>100_bases
GTCCGGCGACGGGCGGCCGCACGCCGCCCCTTCCCTTCCCGACATGGAATTCCAATGAGCGAACTGTCCGTCGAAGCGAG
CATCGGCTCGGTCGATTATC

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSNVELFHYLLLLICGAGALTWLAERLSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKAFRH
ELASIASLALGAVVFTTVAVALAVHAFNPALPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGL
LLYQIAVSAALAVTITTASAAGLFLSLTLIGIAVGFACGQAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEALHGSGVLS
VVSCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNREGAVLMAGLRVALPATAAAIVARI
AWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPAGFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRALKLQPAARHTMSEHAVRAHTFGAALAALDARGQHGTQLERASLERLLTEYRNRVAFNERAYREGAEPADVRARMLRV
ELELVGVSRDALLALHRDGRVDDAVLHRIESELDFEELRLQRLLEP

Sequences:

>Translated_526_residues
MSNVELFHYLLLLICGAGALTWLAERLSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKAFRH
ELASIASLALGAVVFTTVAVALAVHAFNPALPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGL
LLYQIAVSAALAVTITTASAAGLFLSLTLIGIAVGFACGQAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEALHGSGVLS
VVSCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNREGAVLMAGLRVALPATAAAIVARI
AWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPAGFPGRDLILFSTFLLIIATLVVQGGTLAPL
IRALKLQPAARHTMSEHAVRAHTFGAALAALDARGQHGTQLERASLERLLTEYRNRVAFNERAYREGAEPADVRARMLRV
ELELVGVSRDALLALHRDGRVDDAVLHRIESELDFEELRLQRLLEP
>Mature_525_residues
SNVELFHYLLLLICGAGALTWLAERLSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAAVLPPLLMSSGFYTAWKAFRHE
LASIASLALGAVVFTTVAVALAVHAFNPALPWAACFTLGAIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLL
LYQIAVSAALAVTITTASAAGLFLSLTLIGIAVGFACGQAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEALHGSGVLSV
VSCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNREGAVLMAGLRVALPATAAAIVARIA
WVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVVSLAAAIALPAGFPGRDLILFSTFLLIIATLVVQGGTLAPLI
RALKLQPAARHTMSEHAVRAHTFGAALAALDARGQHGTQLERASLERLLTEYRNRVAFNERAYREGAEPADVRARMLRVE
LELVGVSRDALLALHRDGRVDDAVLHRIESELDFEELRLQRLLEP

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=405, Percent_Identity=24.6913580246914, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI15529998, Length=451, Percent_Identity=22.8381374722838, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI4759144, Length=457, Percent_Identity=26.4770240700219, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI14211919, Length=394, Percent_Identity=24.6192893401015, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI148727259, Length=392, Percent_Identity=21.6836734693878, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI294997330, Length=380, Percent_Identity=24.2105263157895, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI110227626, Length=380, Percent_Identity=24.2105263157895, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI5454070, Length=376, Percent_Identity=24.2021276595745, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI41872703, Length=474, Percent_Identity=21.0970464135021, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI194239733, Length=453, Percent_Identity=21.4128035320088, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI27777632, Length=456, Percent_Identity=21.2719298245614, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790501, Length=501, Percent_Identity=29.940119760479, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71980847, Length=462, Percent_Identity=22.7272727272727, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI25150332, Length=447, Percent_Identity=21.7002237136465, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71999819, Length=512, Percent_Identity=20.5078125, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999817, Length=512, Percent_Identity=20.5078125, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71999821, Length=512, Percent_Identity=20.5078125, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25147678, Length=444, Percent_Identity=23.1981981981982, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=402, Percent_Identity=20.6467661691542, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=402, Percent_Identity=20.6467661691542, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71990924, Length=444, Percent_Identity=21.1711711711712, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71990932, Length=445, Percent_Identity=21.123595505618, Blast_Score=79, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI71992101, Length=369, Percent_Identity=19.7831978319783, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71992107, Length=369, Percent_Identity=19.7831978319783, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71987559, Length=425, Percent_Identity=20.4705882352941, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987545, Length=425, Percent_Identity=20.4705882352941, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320663, Length=454, Percent_Identity=19.8237885462555, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281360447, Length=376, Percent_Identity=23.1382978723404, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221473212, Length=376, Percent_Identity=25, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI281364513, Length=376, Percent_Identity=25, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221473215, Length=413, Percent_Identity=23.9709443099274, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221473222, Length=376, Percent_Identity=25, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221510734, Length=433, Percent_Identity=23.5565819861432, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221510738, Length=437, Percent_Identity=23.5697940503432, Blast_Score=87, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221510732, Length=395, Percent_Identity=23.5443037974684, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221510736, Length=397, Percent_Identity=23.6775818639798, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24585580, Length=390, Percent_Identity=23.5897435897436, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585578, Length=390, Percent_Identity=23.5897435897436, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221510740, Length=390, Percent_Identity=23.5897435897436, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 55992; Mature: 55861

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVELFHYLLLLICGAGALTWLAERLSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VLPPLLMSSGFYTAWKAFRHELASIASLALGAVVFTTVAVALAVHAFNPALPWAACFTLG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLLLYQIAVSAALAVTITTASA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHEEEHHHH
AGLFLSLTLIGIAVGFACGQAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEALHGSGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHH
VVSCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNREGAV
HHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LMAGLRVALPATAAAIVARIAWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVV
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHH
SLAAAIALPAGFPGRDLILFSTFLLIIATLVVQGGTLAPLIRALKLQPAARHTMSEHAVR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
AHTFGAALAALDARGQHGTQLERASLERLLTEYRNRVAFNERAYREGAEPADVRARMLRV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELELVGVSRDALLALHRDGRVDDAVLHRIESELDFEELRLQRLLEP
HHHHEECCHHHHHEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SNVELFHYLLLLICGAGALTWLAERLSIPPAVVLLLGGCVVAVAGKRVPDMDPALLLAA
CCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
VLPPLLMSSGFYTAWKAFRHELASIASLALGAVVFTTVAVALAVHAFNPALPWAACFTLG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AIVSPPDAVAAKAILQRHPLPARLVAVLEGESLVNDASGLLLYQIAVSAALAVTITTASA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHEEEHHHH
AGLFLSLTLIGIAVGFACGQAMCWVLQRLREPMLGIVVTFAMAWGSYGIAEALHGSGVLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHH
VVSCGLVLGVRQHRVFDADMRIKAKATWEAIVFVLDALVFILIGLALHAILAGVNREGAV
HHHHHHHHHHHHHHEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
LMAGLRVALPATAAAIVARIAWVFVAMWLPGRLRAPRAGHAPWSWREAVVLGWSGMRGVV
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHH
SLAAAIALPAGFPGRDLILFSTFLLIIATLVVQGGTLAPLIRALKLQPAARHTMSEHAVR
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHH
AHTFGAALAALDARGQHGTQLERASLERLLTEYRNRVAFNERAYREGAEPADVRARMLRV
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ELELVGVSRDALLALHRDGRVDDAVLHRIESELDFEELRLQRLLEP
HHHHEECCHHHHHEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]