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The map label for this gene is livM [H]

Identifier: 161525072

GI number: 161525072

Start: 2077768

End: 2078985

Strand: Reverse

Name: livM [H]

Synonym: Bmul_1900

Alternate gene names: 161525072

Gene position: 2078985-2077768 (Counterclockwise)

Preceding gene: 161525073

Following gene: 161525071

Centisome position: 60.29

GC content: 75.04

Gene sequence:

>1218_bases
ATGCGTAGCGGCCCGTTCGCGGTGTTCGCGCGCTGGGCGCTGTTCGCAGGCTGCCTCGTGCTGCCCGCGTGGCTGTGGCC
GCAGGGCGCAGTGCTCGGCTACCTCGCGCAGACGGCGTCGCTCGTCGTGCTCGCGCTGTCGTACAACCTGCAGCTCGGCA
CGACCGGGCTGCTGTCGTTCGGCCATGCCGCGTTTGCGGGCCTCGGCGCGTTCGCGGCCGCGCACTGGTTCAACCGCTTC
GGCGGCTCGCTGCCGCTGCTGCCGCTCGTCGGCGGCGCGGCCGGCGCAGGCTTCGGCTTCATCGCCGGGCTGCTCGCGAC
GCGCCGCGCGGGCACCGCGTTCGCGATGATCACGCTCGGCCTCGGCGAGTGCGTGGCCGCCGCCGCGTGGAGCGTGCCGG
CATGGTTCGGCGGAATCGGCGGCGTGCCGATCGATCGCGCGAGCGGCACGCCGTGGGGCGGCTGGCAGTTCGGCGCACCG
GTACAGGCGTATGCGGTGATTGCCGCATGGTGCATCGTCTCCGCGCTCGCGATGCGCGCGCTGACGCGCACGCCGCTCGC
GCGACTCGCGAACGCGGTGCGCGACAACCCGGCGCGCGTCGCGGCGCTCGGCACCGATCCGCGCCGCGTGCGGCTCGCGA
TGGTCACGTGCGCCTCGTTCTTCGCGGGCATTGCCGGCACGCTGACGCTGATCGACGTCGAGATCGCGACGCCTGACAGC
GTATCGATGGCGCGTTCCGCCAGCGTGTTGATCGCTGCCGTGATCGGCGGCACCGGCGCCTTCTTTGGACCGGCGGCCGG
CGCGGCGGTGCTGACCGCGCTGAGCGTCGTCGTCGCCGGCATGTCGCGCGCGTGGGCGCTGTACCTCGGCGTGCTGTTCG
TCGCGGTCGTCGTTGCCGCGCCGCGCGGGCTCGCGGGGCTCGTCGACGCGCTCGCGCACGCGCTGCGTCGCGGCGCGCCG
GCGAGCGAGCGCTGGCGGCTGCTGTGCGCGATCGGCGCGTGCGTGTTCTGGGGCATCGCGCTCGTCGCCGCGGCCGAGCT
CGGCTATGCGTGGCGCTTCGCGCAGGACGACGGCCCGGGCACCGCGTTCGGCGCATGGCGGATCGACGCCGATACGCCGG
TCGGCTGGGCCGTGGCCGCGTCGGCGGCTGCCATCGGCATGCTGCTGTGGGGCTGGCGCGCACGCTTCGCGCGTGCCGGC
GCGGAGGAGCGGCGATGA

Upstream 100 bases:

>100_bases
GCGGCCGTGTCGATCGCGCAGCTGGCGCCGCTGGTGCCGTACCTGCTGCTCGTCGCGGTGCTGGTCGCGCGGCCGCGCGG
ACTGTTCGGCGAGCGTGCCG

Downstream 100 bases:

>100_bases
GCGGCACCGCAGTCGCGCTGCGCGCGATCGTGCTGCGCTTCGGTGCGCGGACGGTGCTCGACGGCATCGACCTCGACGTC
GCGGCCGGCGAGCGGCATGC

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MRSGPFAVFARWALFAGCLVLPAWLWPQGAVLGYLAQTASLVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNRF
GGSLPLLPLVGGAAGAGFGFIAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWQFGAP
VQAYAVIAAWCIVSALAMRALTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGIAGTLTLIDVEIATPDS
VSMARSASVLIAAVIGGTGAFFGPAAGAAVLTALSVVVAGMSRAWALYLGVLFVAVVVAAPRGLAGLVDALAHALRRGAP
ASERWRLLCAIGACVFWGIALVAAAELGYAWRFAQDDGPGTAFGAWRIDADTPVGWAVAASAAAIGMLLWGWRARFARAG
AEERR

Sequences:

>Translated_405_residues
MRSGPFAVFARWALFAGCLVLPAWLWPQGAVLGYLAQTASLVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNRF
GGSLPLLPLVGGAAGAGFGFIAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWQFGAP
VQAYAVIAAWCIVSALAMRALTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGIAGTLTLIDVEIATPDS
VSMARSASVLIAAVIGGTGAFFGPAAGAAVLTALSVVVAGMSRAWALYLGVLFVAVVVAAPRGLAGLVDALAHALRRGAP
ASERWRLLCAIGACVFWGIALVAAAELGYAWRFAQDDGPGTAFGAWRIDADTPVGWAVAASAAAIGMLLWGWRARFARAG
AEERR
>Mature_405_residues
MRSGPFAVFARWALFAGCLVLPAWLWPQGAVLGYLAQTASLVVLALSYNLQLGTTGLLSFGHAAFAGLGAFAAAHWFNRF
GGSLPLLPLVGGAAGAGFGFIAGLLATRRAGTAFAMITLGLGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWQFGAP
VQAYAVIAAWCIVSALAMRALTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGIAGTLTLIDVEIATPDS
VSMARSASVLIAAVIGGTGAFFGPAAGAAVLTALSVVVAGMSRAWALYLGVLFVAVVVAAPRGLAGLVDALAHALRRGAP
ASERWRLLCAIGACVFWGIALVAAAELGYAWRFAQDDGPGTAFGAWRIDADTPVGWAVAASAAAIGMLLWGWRARFARAG
AEERR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=309, Percent_Identity=29.126213592233, Blast_Score=89, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 41481; Mature: 41481

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGPFAVFARWALFAGCLVLPAWLWPQGAVLGYLAQTASLVVLALSYNLQLGTTGLLSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNRFGGSLPLLPLVGGAAGAGFGFIAGLLATRRAGTAFAMITLG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
LGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWQFGAPVQAYAVIAAWCIVSALAMRA
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGIAGTLTLIDVEIATPDS
HHHCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSASVLIAAVIGGTGAFFGPAAGAAVLTALSVVVAGMSRAWALYLGVLFVAVVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGLAGLVDALAHALRRGAPASERWRLLCAIGACVFWGIALVAAAELGYAWRFAQDDGPG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
TAFGAWRIDADTPVGWAVAASAAAIGMLLWGWRARFARAGAEERR
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRSGPFAVFARWALFAGCLVLPAWLWPQGAVLGYLAQTASLVVLALSYNLQLGTTGLLSF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHH
GHAAFAGLGAFAAAHWFNRFGGSLPLLPLVGGAAGAGFGFIAGLLATRRAGTAFAMITLG
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHH
LGECVAAAAWSVPAWFGGIGGVPIDRASGTPWGGWQFGAPVQAYAVIAAWCIVSALAMRA
HHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
LTRTPLARLANAVRDNPARVAALGTDPRRVRLAMVTCASFFAGIAGTLTLIDVEIATPDS
HHHCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCCC
VSMARSASVLIAAVIGGTGAFFGPAAGAAVLTALSVVVAGMSRAWALYLGVLFVAVVVAA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGLAGLVDALAHALRRGAPASERWRLLCAIGACVFWGIALVAAAELGYAWRFAQDDGPG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
TAFGAWRIDADTPVGWAVAASAAAIGMLLWGWRARFARAGAEERR
CEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]