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The map label for this gene is pyrD [H]

Identifier: 161524851

GI number: 161524851

Start: 1847055

End: 1848092

Strand: Direct

Name: pyrD [H]

Synonym: Bmul_1678

Alternate gene names: 161524851

Gene position: 1847055-1848092 (Clockwise)

Preceding gene: 161524850

Following gene: 161524852

Centisome position: 53.56

GC content: 69.17

Gene sequence:

>1038_bases
GTGTTCAGTTCCCTCTATCCGCTGGCCCGCGCATCCCTGTTCAAGATGGATGCGGAAGACGCTCACCACCTCACGCTGCG
CGCGCTCGGCGCCGCCGGCCGCACGGGCCTCGCCTGCGCGCTGTCGGCGCGCGTGCCCGACGCACCGCGTACGGTGATGG
GCCTCACGTTCCGCAACCCGGTCGGCCTCGCGGCCGGTCTCGACAAGGACGGCGCGGCCATCGACGGCCTCGCGGCACTC
GGTTTCGGCTTCATCGAGGTCGGCACGGTCACGCCGCGGGCGCAGCCCGGCAATCCGCGCCCGCGGATGTTCCGCCTGCC
GCAGGCCGAGGCGCTGATCAACCGGATGGGCTTCAACAACCACGGCGTCGACCAGTTCGTGAAGAACGTGCAGGCCGCGC
GCTATCGCGGCATCCTCGGCCTGAACATCGGCAAGAACGCCGACACGCCGATCGAGCGCGCCGCCGACGACTATCTGTAC
TGCCTGGAGCGCGTCTACCCGTTCGCGAGCTACGTGACGATCAACATTTCGTCGCCGAACACGAAGAACCTGCGCCAGCT
GCAGGGCGCGGGCGAACTCGACGCGCTGCTCGCCGCACTGAAGGACAAGCAGCAGCGTCTGGCCGACCTGCACGGCAAGC
TCGTGCCGCTCGCGCTGAAGATCGCGCCCGATCTCGACGACGAACAGGTCAAGGCGATCGCCGATACGCTGCTGCGCCAC
AAGATCGAAGCGGTGATCGCGACCAACACGACGTTGTCGCGCGCCGCCGTGCAAGGCCTGCCGCACGCGGACGAAGCGGG
CGGCCTGTCGGGCCGCCCGGTGTTCGACGCGTCGAACGAGGTGATCCGCAAGCTGCACGCCGAAGTCGGCAGCGCGGTGC
CGATCATCGGCGTCGGCGGCATCTTCTCGGGCGACGACGCGCGCGCGAAGCTTGCTGCCGGCGCATCGCTCGTCCAGCTC
TATACCGGCTTCATCTATCGCGGCCCGGCGCTCGTCGCCGAATGCGTGAAGGCGATCGCGCGCGAGCGTGCCGCGTAA

Upstream 100 bases:

>100_bases
GATCGAGGCGCGCGAGCACGCCGGACCAAAGCCCGCCCCTGCCTCACAACTCCCGGTAAAATAGCGGGTTGTCATTCATT
CGGCTGTCCGCCCAATTCCC

Downstream 100 bases:

>100_bases
TATAGGCATAAACAAACGATATTTAGCCGTCGATTGCATTTTTGCTATGATCGACGCCATTGTCAGAACATGAGCCCCGC
CGGGGCAAGGAAGCTCACAC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRH
KIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARERAA

Sequences:

>Translated_345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRH
KIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARERAA
>Mature_345_residues
MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNPVGLAAGLDKDGAAIDGLAAL
GFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNNHGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLY
CLERVYPFASYVTINISSPNTKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRH
KIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGGIFSGDDARAKLAAGASLVQL
YTGFIYRGPALVAECVKAIARERAA

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=336, Percent_Identity=44.3452380952381, Blast_Score=252, Evalue=5e-67,
Organism=Escherichia coli, GI1787177, Length=334, Percent_Identity=57.185628742515, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17509475, Length=337, Percent_Identity=40.9495548961424, Blast_Score=231, Evalue=3e-61,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=44.5945945945946, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=44.5945945945946, Blast_Score=238, Evalue=5e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36591; Mature: 36591

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
VGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCC
HGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
KIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGG
HHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPALVAECVKAIARERAA
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFSSLYPLARASLFKMDAEDAHHLTLRALGAAGRTGLACALSARVPDAPRTVMGLTFRNP
CCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEEEEECCC
VGLAAGLDKDGAAIDGLAALGFGFIEVGTVTPRAQPGNPRPRMFRLPQAEALINRMGFNN
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCC
HGVDQFVKNVQAARYRGILGLNIGKNADTPIERAADDYLYCLERVYPFASYVTINISSPN
CCHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCC
TKNLRQLQGAGELDALLAALKDKQQRLADLHGKLVPLALKIAPDLDDEQVKAIADTLLRH
CHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHH
KIEAVIATNTTLSRAAVQGLPHADEAGGLSGRPVFDASNEVIRKLHAEVGSAVPIIGVGG
HHHHHEECCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECC
IFSGDDARAKLAAGASLVQLYTGFIYRGPALVAECVKAIARERAA
EECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA