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The map label for this gene is lexA [H]

Identifier: 161524810

GI number: 161524810

Start: 1814278

End: 1814925

Strand: Direct

Name: lexA [H]

Synonym: Bmul_1637

Alternate gene names: 161524810

Gene position: 1814278-1814925 (Clockwise)

Preceding gene: 161524791

Following gene: 161524811

Centisome position: 52.61

GC content: 68.21

Gene sequence:

>648_bases
ATGACCAAACTCACCGCACGCCAGCAGCAAGTGTTCGACTTGATCCGCCGCGCGATCGAGCGCTCCGGTTTTCCGCCCAC
TCGCGCCGAGATTGCGGCCGAACTGGGTTTCAGTTCGCCGAACGCGGCCGAGGAGCACCTGCGTGCGCTGGCGCGCAAGG
GCGTGATCGAGCTGGCGGCGGGCGCGTCGCGCGGCATCCGGCTGCTCGGCGGCGACGACGCGCCGCACCAGTTCACGCTG
CCGCATGCGGGGCTGATGCAACTGTCGCTGCCGCTCGTCGGCCGTGTCGCGGCCGGCAGCCCGATCCTCGCGCAGGAACA
CATCTCGCAGCACTTCGCGTGCGATCCCGCGCTGTTCTCGAGCAAGCCCGACTATCTGCTGAAGGTGCGCGGGCTGTCGA
TGCGCGACGCCGGCATTCTCGACGGCGATCTGCTGGCGGTCCAGAAGCGCACCGAAGCGAAGGACGGCCAGATCATCGTC
GCGCGGCTCGGCGACGACGTCACGGTCAAGCGTCTGATGCGCCGGCCGGGCGGCATCGAGCTGATCGCCGAGAACCCGGA
TTACGAAAACATCTTCGTCAAGGCCGGCAGCGCGGATTTCGCGCTGGAAGGCATCGCCGTCGGGCTGATCCGCTCGGGCG
AACTCTGA

Upstream 100 bases:

>100_bases
CGTCGGAACCGGCGCGATCGCGTCGAACTTCACGTAACACTTGAAATTCGCGAAGTACTGTATAAAAATACAGCTCACTG
TCTATCCATACAGTTGAACC

Downstream 100 bases:

>100_bases
CATTCCGTCTCGCTCAGGAGAACACCATGGAACGCCTTGCCCGCCTGCTGCCTTTCCGTCAATTCGGTCGCCTGCGTCAT
CTGCGCGGCCGCACGCCCTG

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGGDDAPHQFTL
PHAGLMQLSLPLVGRVAAGSPILAQEHISQHFACDPALFSSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIV
ARLGDDVTVKRLMRRPGGIELIAENPDYENIFVKAGSADFALEGIAVGLIRSGEL

Sequences:

>Translated_215_residues
MTKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGGDDAPHQFTL
PHAGLMQLSLPLVGRVAAGSPILAQEHISQHFACDPALFSSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIV
ARLGDDVTVKRLMRRPGGIELIAENPDYENIFVKAGSADFALEGIAVGLIRSGEL
>Mature_214_residues
TKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAAGASRGIRLLGGDDAPHQFTLP
HAGLMQLSLPLVGRVAAGSPILAQEHISQHFACDPALFSSKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVA
RLGDDVTVKRLMRRPGGIELIAENPDYENIFVKAGSADFALEGIAVGLIRSGEL

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=215, Percent_Identity=55.3488372093023, Blast_Score=239, Evalue=1e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23094; Mature: 22963

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAA
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHEEEC
GASRGIRLLGGDDAPHQFTLPHAGLMQLSLPLVGRVAAGSPILAQEHISQHFACDPALFS
CCCCCEEEECCCCCCCEEECCCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHC
SKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVARLGDDVTVKRLMRRPGGIE
CCCCEEEEEECCCCCCCCCCCCHHHEEEHHCCCCCCCEEEEECCCCHHHHHHHCCCCCEE
LIAENPDYENIFVKAGSADFALEGIAVGLIRSGEL
EEECCCCCCEEEEECCCCCEEHHHEEEEEEECCCC
>Mature Secondary Structure 
TKLTARQQQVFDLIRRAIERSGFPPTRAEIAAELGFSSPNAAEEHLRALARKGVIELAA
CCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHEEEC
GASRGIRLLGGDDAPHQFTLPHAGLMQLSLPLVGRVAAGSPILAQEHISQHFACDPALFS
CCCCCEEEECCCCCCCEEECCCCCHHHHHCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHC
SKPDYLLKVRGLSMRDAGILDGDLLAVQKRTEAKDGQIIVARLGDDVTVKRLMRRPGGIE
CCCCEEEEEECCCCCCCCCCCCHHHEEEHHCCCCCCCEEEEECCCCHHHHHHHCCCCCEE
LIAENPDYENIFVKAGSADFALEGIAVGLIRSGEL
EEECCCCCCEEEEECCCCCEEHHHEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA