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The map label for this gene is arpR [H]

Identifier: 161524790

GI number: 161524790

Start: 1788792

End: 1789457

Strand: Direct

Name: arpR [H]

Synonym: Bmul_1617

Alternate gene names: 161524790

Gene position: 1788792-1789457 (Clockwise)

Preceding gene: 161524786

Following gene: 161524791

Centisome position: 51.87

GC content: 69.07

Gene sequence:

>666_bases
ATGGCTCGCAAGACCCGGGAAGAATCGCTCGCCATCAAGCACCGGATCCTCGACGCCGCCGAGCTCGTGCTGCTCGACAA
GGGCGTCGCGCAAACCGCGATGGCGGACCTCGCCGAGGCCGCCGGCATGTCGCGCGGCGCCGTGTACGGCCACTACCGCA
ACAAGATGGAGGTGTGCCTCGCGATGTGCGACCGCGCGTTCGCGCGCACGTCCGAGGGCTTCGAGGCCGGCGACGGGCTG
CCGGCGTTCGCGACGCTGCGGCACGCCGCGTCGCACTATCTGCGCCAGTGCGGCGAGCCCGGTTCGATGCAGCGCGTGCT
CGTGATCCTCTATGCGAAGTGCGAGCAAAGCGACGAGAACGCGGCGCTGCTGCGCCGCCGGATGCTGCTCGAATTGCAGA
CGCTGCGGATCACGAAGGCGCTGCTGCGCCGCGCGATCGAGGCGGGCGAACTCGCGGCCGACCTCGACGTGCATCTGGCC
GCCGTCTATCTCGTCTCGCTGCTCGAAGGCGTGTTCGCGTCGATGATCTGGACGAACCGGCTGCGCGGCAACCTGTGGAA
CGACGCCGAAGCGATGCTCGATGCGGGCTTCGACGCGGTGCGGACCTCCGCCGCGCTGCGGCGGCCCGCACACAAGTTGC
CGAAGCCCGCGAAACGATCGCAATAA

Upstream 100 bases:

>100_bases
CCGATTATAATCAGTCACGACTGATTAAATACACCGATCCTCCATCCAATCGTCAGACTGTCTCAATAAAGCGACAGCGT
ACTGTAAGGAAACTCGATAC

Downstream 100 bases:

>100_bases
ATGCCGATTTAACCCGATTTACCGCACTGCGAAACGAGTGAGTCGACCCTCTTTAAAATTTTTAACATCTTCCGGAACAT
CGGTAGGCTCGCGCTGTCAG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MARKTREESLAIKHRILDAAELVLLDKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFEAGDGL
PAFATLRHAASHYLRQCGEPGSMQRVLVILYAKCEQSDENAALLRRRMLLELQTLRITKALLRRAIEAGELAADLDVHLA
AVYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDAGFDAVRTSAALRRPAHKLPKPAKRSQ

Sequences:

>Translated_221_residues
MARKTREESLAIKHRILDAAELVLLDKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFEAGDGL
PAFATLRHAASHYLRQCGEPGSMQRVLVILYAKCEQSDENAALLRRRMLLELQTLRITKALLRRAIEAGELAADLDVHLA
AVYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDAGFDAVRTSAALRRPAHKLPKPAKRSQ
>Mature_220_residues
ARKTREESLAIKHRILDAAELVLLDKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCLAMCDRAFARTSEGFEAGDGLP
AFATLRHAASHYLRQCGEPGSMQRVLVILYAKCEQSDENAALLRRRMLLELQTLRITKALLRRAIEAGELAADLDVHLAA
VYLVSLLEGVFASMIWTNRLRGNLWNDAEAMLDAGFDAVRTSAALRRPAHKLPKPAKRSQ

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789664, Length=202, Percent_Identity=28.7128712871287, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786669, Length=180, Percent_Identity=27.2222222222222, Blast_Score=71, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24376; Mature: 24244

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTREESLAIKHRILDAAELVLLDKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCL
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AMCDRAFARTSEGFEAGDGLPAFATLRHAASHYLRQCGEPGSMQRVLVILYAKCEQSDEN
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCH
AALLRRRMLLELQTLRITKALLRRAIEAGELAADLDVHLAAVYLVSLLEGVFASMIWTNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGNLWNDAEAMLDAGFDAVRTSAALRRPAHKLPKPAKRSQ
HCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARKTREESLAIKHRILDAAELVLLDKGVAQTAMADLAEAAGMSRGAVYGHYRNKMEVCL
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
AMCDRAFARTSEGFEAGDGLPAFATLRHAASHYLRQCGEPGSMQRVLVILYAKCEQSDEN
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCH
AALLRRRMLLELQTLRITKALLRRAIEAGELAADLDVHLAAVYLVSLLEGVFASMIWTNR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRGNLWNDAEAMLDAGFDAVRTSAALRRPAHKLPKPAKRSQ
HCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]