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The map label for this gene is metC [H]

Identifier: 161524664

GI number: 161524664

Start: 1642177

End: 1643358

Strand: Direct

Name: metC [H]

Synonym: Bmul_1491

Alternate gene names: 161524664

Gene position: 1642177-1643358 (Clockwise)

Preceding gene: 161524663

Following gene: 161524667

Centisome position: 47.62

GC content: 68.1

Gene sequence:

>1182_bases
ATGACTGAATCCACCTCGAAGCGCGCACTGCAGACCCGTATCGTTCAACCCGACGACGTCATTCCGGAGGGCTTCCGCTC
GTTCGTGCCGCCGGTCGCGCGCGCGTCGACGGTCGTGTTTCCCGATCTCGCGACGATGCGCCAGCTCGACTGGCGCAAGG
ACGGCCAGTGGCGCTACGGGCTGCATGCGACGCCGACGTCGCTCGCGCTCGCGCAGCGGCTCGGCGAGATCGAGGGCGGC
ACGCACGCGCTGCTGCAACCGTCGGGGCTCGCGGCGATCATGAACGTCTATTTCGCCGTCGTGAAAGCGGGCGACGACGT
GCTGATTCCGCACAACGTCTACGGCCCGAACGCCGATTTCGGCAACTGGCTCGCGAAGGATTTCGGCATTTCCGCGCGCT
TCTACGATCCGCTGATCGGTGCCGGCATCGCCGAGCTGATCCAGCCGAACACGCGGCTGATCTGGCTCGAGGCGCCCGGC
TCGGTGACGATGGAAGTGCCCGACGTGCGCGCGATCACGGCGGCCGCCCGGGCGCGCGGCGTCGTCACCGCAATCGACAA
CACATATTCGGCGGGCCTCGCGTTCAAGCCGTTCGAGCACGGCGTCGACATCTCGGTGCAGGCGCTGACCAAATACCAGT
CCGGCGGTAGCGATCTGCTGATGGGCGCGACGATCACCGCGAACGCGGAACTGCATGCGCAGCTGAAGCTCGCACGGATG
CGCTGCGGCGTCGGCGTGTCGGTCGACGACTGCTCGCTCGTGCTGCGGAGCCTGCCGAGCATGCAGCTGCGCTTCGACGC
GCACAGCAAGAGCGCGCTGTCGCTCGCGAAGTGGCTGAAGACGCGGCCCGAGATCGCCACCGTGCTGCATCCGCAACTGC
CCGACTGTCCGGGCCACGCGTCGTTCGTTCGCGACTTCACGGGCGCGGGCGGGCTGTTCTCGGTGGTGTTCGACGAGCGG
TACAGCGTCGCGCAGGTCGATCGTTTCGTCGAGTCGCTCGAGCTGTTCGCGATCGGCTGGAGCTGGGGCGGCGCGTGCAG
CCTCGCGGTGCCGTACGACGTCGCGTCGATGCGGCCCGAGTGGCCGCATCGCGGCACGCTGGTGCGCTTCTACATCGGTC
TCGAAGACGAAGCCGATCTGCGCGCGGACATCGAACGCGCGCTGCACGCGGCGCTCGGCTGA

Upstream 100 bases:

>100_bases
TCGGTTCGCGCGCCGCGCATTGTACCGGGCCAAACGCGGCGGTTTTGACTAACCTAGCGACATATCCGCAACCGTAGGCC
GCCTGTCCGGCTTCCTTGTC

Downstream 100 bases:

>100_bases
GTCCCGCATACGCGTAGCACGCTGCGGCAAAAAGAAACGCCGGCGCGAAGCGATTCGCGCCGGCGTTGTCGTTTCTAGTG
TGCGCGGCGTTGCGCGTCAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTESTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRQLDWRKDGQWRYGLHATPTSLALAQRLGEIEGG
THALLQPSGLAAIMNVYFAVVKAGDDVLIPHNVYGPNADFGNWLAKDFGISARFYDPLIGAGIAELIQPNTRLIWLEAPG
SVTMEVPDVRAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDLLMGATITANAELHAQLKLARM
RCGVGVSVDDCSLVLRSLPSMQLRFDAHSKSALSLAKWLKTRPEIATVLHPQLPDCPGHASFVRDFTGAGGLFSVVFDER
YSVAQVDRFVESLELFAIGWSWGGACSLAVPYDVASMRPEWPHRGTLVRFYIGLEDEADLRADIERALHAALG

Sequences:

>Translated_393_residues
MTESTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRQLDWRKDGQWRYGLHATPTSLALAQRLGEIEGG
THALLQPSGLAAIMNVYFAVVKAGDDVLIPHNVYGPNADFGNWLAKDFGISARFYDPLIGAGIAELIQPNTRLIWLEAPG
SVTMEVPDVRAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDLLMGATITANAELHAQLKLARM
RCGVGVSVDDCSLVLRSLPSMQLRFDAHSKSALSLAKWLKTRPEIATVLHPQLPDCPGHASFVRDFTGAGGLFSVVFDER
YSVAQVDRFVESLELFAIGWSWGGACSLAVPYDVASMRPEWPHRGTLVRFYIGLEDEADLRADIERALHAALG
>Mature_392_residues
TESTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRQLDWRKDGQWRYGLHATPTSLALAQRLGEIEGGT
HALLQPSGLAAIMNVYFAVVKAGDDVLIPHNVYGPNADFGNWLAKDFGISARFYDPLIGAGIAELIQPNTRLIWLEAPGS
VTMEVPDVRAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDLLMGATITANAELHAQLKLARMR
CGVGVSVDDCSLVLRSLPSMQLRFDAHSKSALSLAKWLKTRPEIATVLHPQLPDCPGHASFVRDFTGAGGLFSVVFDERY
SVAQVDRFVESLELFAIGWSWGGACSLAVPYDVASMRPEWPHRGTLVRFYIGLEDEADLRADIERALHAALG

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=28.9230769230769, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI299473759, Length=227, Percent_Identity=30.8370044052863, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI25453487, Length=324, Percent_Identity=26.5432098765432, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1789383, Length=362, Percent_Identity=39.2265193370166, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=29.7872340425532, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=377, Percent_Identity=31.0344827586207, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17538055, Length=328, Percent_Identity=29.5731707317073, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=27.9255319148936, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=324, Percent_Identity=38.5802469135802, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6319307, Length=352, Percent_Identity=27.8409090909091, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321904, Length=394, Percent_Identity=25.6345177664975, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323333, Length=418, Percent_Identity=24.8803827751196, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6321254, Length=259, Percent_Identity=28.1853281853282, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922554, Length=390, Percent_Identity=32.5641025641026, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42700; Mature: 42569

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRQLDWRKDGQWRYG
CCCCHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHHHCCCCCCCCEEEC
LHATPTSLALAQRLGEIEGGTHALLQPSGLAAIMNVYFAVVKAGDDVLIPHNVYGPNADF
CCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLAKDFGISARFYDPLIGAGIAELIQPNTRLIWLEAPGSVTMEVPDVRAITAAARARG
HHHHHHHHCCCCHHHCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDLLMGATITANAELHAQLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHH
RCGVGVSVDDCSLVLRSLPSMQLRFDAHSKSALSLAKWLKTRPEIATVLHPQLPDCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFVRDFTGAGGLFSVVFDERYSVAQVDRFVESLELFAIGWSWGGACSLAVPYDVASMRPE
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYIGLEDEADLRADIERALHAALG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TESTSKRALQTRIVQPDDVIPEGFRSFVPPVARASTVVFPDLATMRQLDWRKDGQWRYG
CCCHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHCCEEECCCHHHHHHCCCCCCCCEEEC
LHATPTSLALAQRLGEIEGGTHALLQPSGLAAIMNVYFAVVKAGDDVLIPHNVYGPNADF
CCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCH
GNWLAKDFGISARFYDPLIGAGIAELIQPNTRLIWLEAPGSVTMEVPDVRAITAAARARG
HHHHHHHHCCCCHHHCHHHHHHHHHHHCCCCEEEEEECCCCEEEECCCHHHHHHHHHHCC
VVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDLLMGATITANAELHAQLKLARM
EEEEECCCCCCCEEECCHHCCCCEEEEEHHHHCCCCCCEEEEEEEEECCCHHHHHHHHHH
RCGVGVSVDDCSLVLRSLPSMQLRFDAHSKSALSLAKWLKTRPEIATVLHPQLPDCPGHA
HCCCCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHCCCCCCCCCCHH
SFVRDFTGAGGLFSVVFDERYSVAQVDRFVESLELFAIGWSWGGACSLAVPYDVASMRPE
HHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEECCCCCEEEEECCCCHHHCCCC
WPHRGTLVRFYIGLEDEADLRADIERALHAALG
CCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]