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The map label for this gene is hflK [H]

Identifier: 161524643

GI number: 161524643

Start: 1616488

End: 1617828

Strand: Direct

Name: hflK [H]

Synonym: Bmul_1470

Alternate gene names: 161524643

Gene position: 1616488-1617828 (Clockwise)

Preceding gene: 161524642

Following gene: 161524644

Centisome position: 46.88

GC content: 69.35

Gene sequence:

>1341_bases
GTGAACGAATACAACGAGCGGAGTACCTGGCGGCGGATGCGCGCCTTGCTGTCGATCAACGATCCCCGCTGGGGGCGCGG
CGAAGGCAATGGCAACGGCGGTTCCCGTCCGCGCGCGAACGAATCGAAGCGTCCGCCCGGCGGCGACGGCGACGGTCCGC
CCGATCTCGACGAGATGTGGCGCAATTTCAACCGCCGCCTGAGCGGGCTGTTCGGCGGCAAGGGCGGCAACGGTTTCCGT
CCCGATAACGGGCGCGCGGCGCGCGTCGGCGTCGGCATCGTGATCGGCGTGCTGATCGCGGTCTATGCCGGCAGCGGCCT
GTTCGTCGTCCAGGAAGGTCAGACGGGCGTCGTCCTGCAGCTCGGCAAGCTGGCCGGCACGGTCGGCCAGGGCGTGCACT
GGCGCGCGCCGTATCCGTTCGCGTCGCACGAGATCGTCGACACGACGCAGGTGCGCTCGATCGAGATCGGCCGCAACAAC
GTCGTGCGGCTCGCCAACGTCAAGGAAGCGGCGATGCTCACGCGCGATGCGGACATCGTCGACGTGCGCTTCATCGTCCA
GTACCGCATTCGCTCCGCCACCGACTATCTGTTCCGCAGCGTCGATCCCGAACGCAGCGTGTCGCAGGCCGCGCAGGCGG
CGGTGCGCGCGATCGTCGGCACGCGCAGCGCGGCCGACCTGCTGAGCCAGGATCGCGACGCGATGCGCGAGCAACTGTCG
GCCGCGATTCAGCGCGATCTCGACCGTTATCGGACGGGCCTCGAAGTGACGGCCGTCACGATGCAGCGCGTCGCGGCGCC
CGAGCAGACGCAGTCCGCCTATGCGGACGTCGCGAAGGCGCGCGACGAGCGCGAGGCCGCGAAGCGCGCCGCGCAGGCCT
ACGCGAGCGAGCTGCTGCCGAAGGCGCAGGGCGATGCCGCGAAGCTGATCGACGATGCGAAGGCCTATGCGGAGCGCGTC
GTCACCGAAGCGCAAGGCGACGCGGAGCGTTTCACGCAGGTCTACGCCGCGTATTCGAAGGCGCCCGCGGTCGTTCGCGA
ACGGATGTACGTCGACACGATGCAGGAAATCTATTCGAACGCGACGAAGGTTTTCGTCGGCAACAACGGCAACAACGTCG
TCTATCTGCCGCTCGACAAGCTCGTCGAGCAGCAGCGGCAAAACGCAGCGGCGTCGGCCGGCGCGGCGGCGACCGATGCG
GCCTCGGCACCGGCGGCTGCGTCGGGCGGCGCCGCCGCAACCGCGGCATCGACGCCGGCGGCCGCAGCGGCACCGGGCAG
CGATGCGCTGCGATCGCGAGAAGCGTTCCGCAGCCGGTCGCGCGAAGACGATCTGAAGTAA

Upstream 100 bases:

>100_bases
GCGCGCCCGCTGAACCGCACGAAGACCACACGATTTCCGAACACGGGCGCTAACCGGTCCCGGCCGGTTCGCCGGCGTCT
AATCTGGTGAACAAACTCTG

Downstream 100 bases:

>100_bases
CGGGGAGCGCAGAACATGAATCGAATCGTTGCGCTCGTCGTCGCAATCGTGATCCTGGCTTTCGCGGCATCGTCGACCGT
GCTGACCGTCGATCCGCGCC

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGNGGSRPRANESKRPPGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLIAVYAGSGLFVVQEGQTGVVLQLGKLAGTVGQGVHWRAPYPFASHEIVDTTQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADLLSQDRDAMREQLS
AAIQRDLDRYRTGLEVTAVTMQRVAAPEQTQSAYADVAKARDEREAAKRAAQAYASELLPKAQGDAAKLIDDAKAYAERV
VTEAQGDAERFTQVYAAYSKAPAVVRERMYVDTMQEIYSNATKVFVGNNGNNVVYLPLDKLVEQQRQNAAASAGAAATDA
ASAPAAASGGAAATAASTPAAAAAPGSDALRSREAFRSRSREDDLK

Sequences:

>Translated_446_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGNGGSRPRANESKRPPGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLIAVYAGSGLFVVQEGQTGVVLQLGKLAGTVGQGVHWRAPYPFASHEIVDTTQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADLLSQDRDAMREQLS
AAIQRDLDRYRTGLEVTAVTMQRVAAPEQTQSAYADVAKARDEREAAKRAAQAYASELLPKAQGDAAKLIDDAKAYAERV
VTEAQGDAERFTQVYAAYSKAPAVVRERMYVDTMQEIYSNATKVFVGNNGNNVVYLPLDKLVEQQRQNAAASAGAAATDA
ASAPAAASGGAAATAASTPAAAAAPGSDALRSREAFRSRSREDDLK
>Mature_446_residues
MNEYNERSTWRRMRALLSINDPRWGRGEGNGNGGSRPRANESKRPPGGDGDGPPDLDEMWRNFNRRLSGLFGGKGGNGFR
PDNGRAARVGVGIVIGVLIAVYAGSGLFVVQEGQTGVVLQLGKLAGTVGQGVHWRAPYPFASHEIVDTTQVRSIEIGRNN
VVRLANVKEAAMLTRDADIVDVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADLLSQDRDAMREQLS
AAIQRDLDRYRTGLEVTAVTMQRVAAPEQTQSAYADVAKARDEREAAKRAAQAYASELLPKAQGDAAKLIDDAKAYAERV
VTEAQGDAERFTQVYAAYSKAPAVVRERMYVDTMQEIYSNATKVFVGNNGNNVVYLPLDKLVEQQRQNAAASAGAAATDA
ASAPAAASGGAAATAASTPAAAAAPGSDALRSREAFRSRSREDDLK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=402, Percent_Identity=29.6019900497512, Blast_Score=175, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: NA

Molecular weight: Translated: 47890; Mature: 47890

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEYNERSTWRRMRALLSINDPRWGRGEGNGNGGSRPRANESKRPPGGDGDGPPDLDEMW
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RNFNRRLSGLFGGKGGNGFRPDNGRAARVGVGIVIGVLIAVYAGSGLFVVQEGQTGVVLQ
HHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGKLAGTVGQGVHWRAPYPFASHEIVDTTQVRSIEIGRNNVVRLANVKEAAMLTRDADIV
HHHHHHHHCCCCEECCCCCCCCCCCCCCHHEEEEEECCCCEEEECCHHHHHHHHCCCCHH
DVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADLLSQDRDAMREQLS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AAIQRDLDRYRTGLEVTAVTMQRVAAPEQTQSAYADVAKARDEREAAKRAAQAYASELLP
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KAQGDAAKLIDDAKAYAERVVTEAQGDAERFTQVYAAYSKAPAVVRERMYVDTMQEIYSN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATKVFVGNNGNNVVYLPLDKLVEQQRQNAAASAGAAATDAASAPAAASGGAAATAASTPA
CEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAAAPGSDALRSREAFRSRSREDDLK
CCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNEYNERSTWRRMRALLSINDPRWGRGEGNGNGGSRPRANESKRPPGGDGDGPPDLDEMW
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RNFNRRLSGLFGGKGGNGFRPDNGRAARVGVGIVIGVLIAVYAGSGLFVVQEGQTGVVLQ
HHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEE
LGKLAGTVGQGVHWRAPYPFASHEIVDTTQVRSIEIGRNNVVRLANVKEAAMLTRDADIV
HHHHHHHHCCCCEECCCCCCCCCCCCCCHHEEEEEECCCCEEEECCHHHHHHHHCCCCHH
DVRFIVQYRIRSATDYLFRSVDPERSVSQAAQAAVRAIVGTRSAADLLSQDRDAMREQLS
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
AAIQRDLDRYRTGLEVTAVTMQRVAAPEQTQSAYADVAKARDEREAAKRAAQAYASELLP
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KAQGDAAKLIDDAKAYAERVVTEAQGDAERFTQVYAAYSKAPAVVRERMYVDTMQEIYSN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
ATKVFVGNNGNNVVYLPLDKLVEQQRQNAAASAGAAATDAASAPAAASGGAAATAASTPA
CEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
AAAAPGSDALRSREAFRSRSREDDLK
CCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]