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The map label for this gene is moaE [H]

Identifier: 161524596

GI number: 161524596

Start: 1566606

End: 1567082

Strand: Direct

Name: moaE [H]

Synonym: Bmul_1423

Alternate gene names: 161524596

Gene position: 1566606-1567082 (Clockwise)

Preceding gene: 161524595

Following gene: 161524598

Centisome position: 45.43

GC content: 68.55

Gene sequence:

>477_bases
ATGGCGACCGTACGAGTGCAGAACGACGATTTCGATCTGAACGCCGAGGTGGCGGCGCTGCGCGCGCGCAATCCGAAGAT
CGGCGCAGTCGCGTGCTTCGTCGGCACCGTGCGCGACCTGAACGAAGGCGACGCGGTGGCCGCGCTGGAGCTCGAGCACT
ATCCGGGGATGACCGAGAAGGCGCTCGAGAAGATCGCGGCGGAGGCCGGCCGGCGCTGGCCGGGCATCGACGTCGCGATC
GTCCATCGGGTCGGCAAGCTGTATCCGCTCGACCAGATCGTGATGGTGGCGACGGTCGCCGCCCATCGCGGCGACGCGTT
CGCGTCGTGCGAATTCGTGATGGATTACCTGAAGACCGATGCGCCGTTCTGGAAGAAGGAGACGACGCCGGACGGCGAAC
GCTGGGTCGACGCGCGCAGCACCGACGATGCGGCGCTGGCGCGCTGGGGGATCGAGTCGCGCAACGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
TCACCGACGGCTGCGAGGTCGCGTTCTTTCCGCCCGTCACGGGCGGCTGAGCGATGCGTTCGGTAGAGGCGGCCGGCGGC
GCGCCGGCAGGGAGCGAATG

Downstream 100 bases:

>100_bases
GTGCGGTTCTGCGACCGTGGCCGCAGCTGCGCGGTGCCGGGCCGGCGTCCCGCGGCGGCCCGCGCGGGCGGTGCAGCGCC
GAAAGCCGACGAGGGCGGCG

Product: molybdopterin biosynthesis MoaE protein

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MATVRVQNDDFDLNAEVAALRARNPKIGAVACFVGTVRDLNEGDAVAALELEHYPGMTEKALEKIAAEAGRRWPGIDVAI
VHRVGKLYPLDQIVMVATVAAHRGDAFASCEFVMDYLKTDAPFWKKETTPDGERWVDARSTDDAALARWGIESRNAAR

Sequences:

>Translated_158_residues
MATVRVQNDDFDLNAEVAALRARNPKIGAVACFVGTVRDLNEGDAVAALELEHYPGMTEKALEKIAAEAGRRWPGIDVAI
VHRVGKLYPLDQIVMVATVAAHRGDAFASCEFVMDYLKTDAPFWKKETTPDGERWVDARSTDDAALARWGIESRNAAR
>Mature_157_residues
ATVRVQNDDFDLNAEVAALRARNPKIGAVACFVGTVRDLNEGDAVAALELEHYPGMTEKALEKIAAEAGRRWPGIDVAIV
HRVGKLYPLDQIVMVATVAAHRGDAFASCEFVMDYLKTDAPFWKKETTPDGERWVDARSTDDAALARWGIESRNAAR

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=113, Percent_Identity=35.3982300884956, Blast_Score=84, Evalue=6e-17,
Organism=Escherichia coli, GI1787003, Length=139, Percent_Identity=53.9568345323741, Blast_Score=156, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17509279, Length=122, Percent_Identity=31.9672131147541, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356259, Length=128, Percent_Identity=35.9375, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 17357; Mature: 17226

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVRVQNDDFDLNAEVAALRARNPKIGAVACFVGTVRDLNEGDAVAALELEHYPGMTEK
CCEEEECCCCCCCCHHHEEEECCCCCCEEHHHHHHHHHCCCCCCEEEEEEECCCCCCHHH
ALEKIAAEAGRRWPGIDVAIVHRVGKLYPLDQIVMVATVAAHRGDAFASCEFVMDYLKTD
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
APFWKKETTPDGERWVDARSTDDAALARWGIESRNAAR
CCCCCCCCCCCHHHEECCCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATVRVQNDDFDLNAEVAALRARNPKIGAVACFVGTVRDLNEGDAVAALELEHYPGMTEK
CEEEECCCCCCCCHHHEEEECCCCCCEEHHHHHHHHHCCCCCCEEEEEEECCCCCCHHH
ALEKIAAEAGRRWPGIDVAIVHRVGKLYPLDQIVMVATVAAHRGDAFASCEFVMDYLKTD
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
APFWKKETTPDGERWVDARSTDDAALARWGIESRNAAR
CCCCCCCCCCCHHHEECCCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]