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The map label for this gene is coaBC [H]

Identifier: 161523961

GI number: 161523961

Start: 858026

End: 859237

Strand: Reverse

Name: coaBC [H]

Synonym: Bmul_0781

Alternate gene names: 161523961

Gene position: 859237-858026 (Counterclockwise)

Preceding gene: 161523962

Following gene: 161523960

Centisome position: 24.92

GC content: 68.23

Gene sequence:

>1212_bases
TTGGCACACGCGGAACTCGCAGGAAAACACCTCGTTCTCGGCCTGACCGGCGGCATCGCCTGCTACAAGATCGCCGAGCT
GACCCGGCTGCTCACGAAAGCCGGAGCGACCGTGCAGGTCGCGATGACGGAAGCCGCCACGCAGTTCATCACGCCCGTCA
CGATGCAGGCGCTGTCCGGCCGCCCCGTCTACACGAGCCAGTGGGATGCGCGCATCGACAACAACATGGCGCATATCGAC
CTGTCGCGCGAAGCCGACGCGATCGTGATCGCGCCCGCGTCGACCGATTTCCTCGCGAAGCTCGCACACGGCTTCGCGGA
CGATCTGCTGTCGACGCTCTGCGTCGCGCGCGACTGTCCGCTGCTCGTCGTGCCCGCGATGAACCGGCAGATGTGGCAGA
ACCCGGCCACGCAGCGCAACGTCGCGCAACTGCGTGCCGACGGCGTGTCGGTGCTCGGCCCCGACTCCGGCGCGCAGGCG
TGCGGCGAAGTCGGCGACGGCCGCATGCTCGAACCCGAAGCGATCTACGAAGCGATCGTCTCGCACTTCCGGCCGAATCG
GCTTGCGCATCGGCGCGTGCTGATCACGGCCGGCCCGACCTTCGAGCCGCTCGATCCGGTGCGCGGCCTCACGAACCGCT
CGAGCGGCAAGATGGGTTTCGCGCTCGCGCGCGCCGCGCAGCAGGCCGGCGCCGAAGTCCATCTGGTCGCCGGCCCGGTC
GCGCTCGACACGCCGTGGGGCGTGTACCGCGAGGATGTGCAGACCGCGCAGCAGATGTACGAGGCGGTGATGAACGCGAT
CAACGATGCCGACATCTTCATCGCGGTTGCCGCGGTCGCCGACTGGCGCGTTGCGCAGCCGGCCGAGCACAAGATGAAGA
AGACGGCCGACCGCAAGATGCCGCCGCTCGAATTCGTCGAGAATCCCGACATCCTCGCGTCGGTCGCGGCGCTGCCCGAT
CCGCCGTTCTGCGTCGGCTTCGCGGCCGAAAGCGGCGACCTCGACGTGCACGGCGACGAAAAGCGCAAGCGCAAGAACGT
GCCGCTGCTGGTCGGCAATCTCGGCCCGCTGACGTTCGGCCGCGACGACAACGAAGTCGTGCTGTTCGACGAAAGCGGCC
TCACGCGGCTGCCGCGTGCGCCGAAGGACGAGCTCGCGCACGCGATCGTCGACGAAATCGCGAAGCGCCTGCCGGACAAC
AGCCTGATCTGA

Upstream 100 bases:

>100_bases
ACGAACTGCGTCGCGTGCGCGGCGCACGCTAAGCGCGCATACTCTGCGTCGGCGGCCGGCGTGCGTGCCGGCCGTCTCGT
TCGACCCTTGGAGGCCTGAG

Downstream 100 bases:

>100_bases
ACTTCCGCGCGGCGGCACGCGCCGCCGCGCCCTTCCCGACCGATTCGAACCGCATGAAACTCGACCTGAAGATTCTCGAC
GCGCGCATGCGCGACTACCT

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARIDNNMAHID
LSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNVAQLRADGVSVLGPDSGAQA
CGEVGDGRMLEPEAIYEAIVSHFRPNRLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
ALDTPWGVYREDVQTAQQMYEAVMNAINDADIFIAVAAVADWRVAQPAEHKMKKTADRKMPPLEFVENPDILASVAALPD
PPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFDESGLTRLPRAPKDELAHAIVDEIAKRLPDN
SLI

Sequences:

>Translated_403_residues
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARIDNNMAHID
LSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNVAQLRADGVSVLGPDSGAQA
CGEVGDGRMLEPEAIYEAIVSHFRPNRLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
ALDTPWGVYREDVQTAQQMYEAVMNAINDADIFIAVAAVADWRVAQPAEHKMKKTADRKMPPLEFVENPDILASVAALPD
PPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFDESGLTRLPRAPKDELAHAIVDEIAKRLPDN
SLI
>Mature_402_residues
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSGRPVYTSQWDARIDNNMAHIDL
SREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCPLLVVPAMNRQMWQNPATQRNVAQLRADGVSVLGPDSGAQAC
GEVGDGRMLEPEAIYEAIVSHFRPNRLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPVA
LDTPWGVYREDVQTAQQMYEAVMNAINDADIFIAVAAVADWRVAQPAEHKMKKTADRKMPPLEFVENPDILASVAALPDP
PFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFGRDDNEVVLFDESGLTRLPRAPKDELAHAIVDEIAKRLPDNS
LI

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=35.5932203389831, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=49.2462311557789, Blast_Score=340, Evalue=1e-94,
Organism=Caenorhabditis elegans, GI17560194, Length=177, Percent_Identity=33.8983050847458, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=31.2169312169312, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=33.6842105263158, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43395; Mature: 43264

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSG
CCCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
RPVYTSQWDARIDNNMAHIDLSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCP
CCCCCCCCCCHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNVAQLRADGVSVLGPDSGAQACGEVGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHH
SHFRPNRLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
HHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCE
ALDTPWGVYREDVQTAQQMYEAVMNAINDADIFIAVAAVADWRVAQPAEHKMKKTADRKM
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHCCCCCCCHHHHHHHHHHCCC
PPLEFVENPDILASVAALPDPPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFG
CCHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
RDDNEVVLFDESGLTRLPRAPKDELAHAIVDEIAKRLPDNSLI
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AHAELAGKHLVLGLTGGIACYKIAELTRLLTKAGATVQVAMTEAATQFITPVTMQALSG
CCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCC
RPVYTSQWDARIDNNMAHIDLSREADAIVIAPASTDFLAKLAHGFADDLLSTLCVARDCP
CCCCCCCCCCHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCC
LLVVPAMNRQMWQNPATQRNVAQLRADGVSVLGPDSGAQACGEVGDGRMLEPEAIYEAIV
EEEEECCCHHHHCCCCCHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCCCHHHHHHHHH
SHFRPNRLAHRRVLITAGPTFEPLDPVRGLTNRSSGKMGFALARAAQQAGAEVHLVAGPV
HHCCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCE
ALDTPWGVYREDVQTAQQMYEAVMNAINDADIFIAVAAVADWRVAQPAEHKMKKTADRKM
EECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHCCCCCCCHHHHHHHHHHCCC
PPLEFVENPDILASVAALPDPPFCVGFAAESGDLDVHGDEKRKRKNVPLLVGNLGPLTFG
CCHHHCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHCCCCEEEECCCCEEEC
RDDNEVVLFDESGLTRLPRAPKDELAHAIVDEIAKRLPDNSLI
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]