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The map label for this gene is adk [H]

Identifier: 161523928

GI number: 161523928

Start: 820412

End: 821074

Strand: Reverse

Name: adk [H]

Synonym: Bmul_0748

Alternate gene names: 161523928

Gene position: 821074-820412 (Counterclockwise)

Preceding gene: 161523929

Following gene: 161523925

Centisome position: 23.81

GC content: 64.1

Gene sequence:

>663_bases
ATGCGTTTGATCCTGTTGGGCGCGCCCGGCGCGGGAAAGGGCACCCAGGCAAACTTCATCAAGGAAAAGTTCGGCATCCC
GCAGATCTCGACCGGCGACATGCTGCGCGCGGCCGTCAAGGCCGGCACGCCGCTCGGCGTCGAAGCGAAGGGCTACATGG
ACGCCGGCAAACTCGTCCCGGACGCGCTGATCATCGGCCTCGTGAAGGAACGTCTGAAGGAAGCGGACTGCGCGAACGGC
TATCTGTTCGACGGCTTTCCGCGCACGATCGCGCAGGCCGACGCGATGAAGGAAGCGGGCGTCGCGATCGACTACGTGCT
CGAGATCGACGTGCCGTTCTCGGAAATCATCGAACGGATGAGCGGCCGCCGCACGCACCCGGCATCGGGCCGCACGTATC
ACGTGAAGTTCAATCCGCCGAAGGTCGAAGGCAAGGACGACGTGACGGGCGAGCCGCTGATCCAGCGCGACGACGACAAG
GAAGAAACGGTGAAGAAGCGCCTCGAGGTGTACGAGGCGCAGACCAAGCCGCTGATCACGTATTACGGCGACTGGGCGAA
GCGCGGCGAGGAAAACGGCCTGAAGGCGCCGCAGTATCGCAAGATCTCCGGGCTCGGCACCGTCGAGGAAATCCGCGAGC
GCGCATTCGACGCGCTGAAGTAA

Upstream 100 bases:

>100_bases
GCGTCAGACCGGTCCGCCGCCGCGCCGCGCAAGCGCCGTGCACGCTGTCGCCGACACCTTCGCGTCTCGCCATACGAATC
TACATACCGGAGATATCATC

Downstream 100 bases:

>100_bases
TCGGCGCGCATACGTCGCGCCACGCAAGCCGCCCCTTCCGGGCGGCTTTTTTTGCGCGCGCGTTTGTGCCGCGTCAGTCT
TCGGCGTCGCGCTGCATCCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAKRGEENGLKAPQYRKISGLGTVEEIRERAFDALK

Sequences:

>Translated_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAKRGEENGLKAPQYRKISGLGTVEEIRERAFDALK
>Mature_220_residues
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVPDALIIGLVKERLKEADCANG
YLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERMSGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDK
EETVKKRLEVYEAQTKPLITYYGDWAKRGEENGLKAPQYRKISGLGTVEEIRERAFDALK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502013, Length=202, Percent_Identity=50, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI7524346, Length=202, Percent_Identity=50, Blast_Score=202, Evalue=2e-52,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=50, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI310110345, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI53832003, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI8051579, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI53832001, Length=182, Percent_Identity=44.5054945054945, Blast_Score=164, Evalue=6e-41,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=30.1075268817204, Blast_Score=107, Evalue=7e-24,
Organism=Homo sapiens, GI4502011, Length=222, Percent_Identity=28.8288288288288, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=30.0518134715026, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI28144899, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI28144897, Length=216, Percent_Identity=27.3148148148148, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI237858799, Length=139, Percent_Identity=27.3381294964029, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=27.3381294964029, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786680, Length=212, Percent_Identity=65.5660377358491, Blast_Score=276, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=46.2365591397849, Blast_Score=179, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=190, Percent_Identity=38.4210526315789, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=32.4175824175824, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=29.8913043478261, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.4347826086957, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320432, Length=194, Percent_Identity=47.9381443298969, Blast_Score=192, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6321018, Length=184, Percent_Identity=46.7391304347826, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6322828, Length=188, Percent_Identity=29.2553191489362, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=52.1739130434783, Blast_Score=200, Evalue=5e-52,
Organism=Drosophila melanogaster, GI17737899, Length=202, Percent_Identity=46.5346534653465, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24645822, Length=202, Percent_Identity=46.5346534653465, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24663208, Length=179, Percent_Identity=27.3743016759777, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647141, Length=179, Percent_Identity=27.3743016759777, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=29.7297297297297, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 24227; Mature: 24227

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAKRGEENGLKAPQYRKISGLGTVEEIRERAFDALK
ECCCHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRLILLGAPGAGKGTQANFIKEKFGIPQISTGDMLRAAVKAGTPLGVEAKGYMDAGKLVP
CEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
DALIIGLVKERLKEADCANGYLFDGFPRTIAQADAMKEAGVAIDYVLEIDVPFSEIIERM
HHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHH
SGRRTHPASGRTYHVKFNPPKVEGKDDVTGEPLIQRDDDKEETVKKRLEVYEAQTKPLIT
HCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
YYGDWAKRGEENGLKAPQYRKISGLGTVEEIRERAFDALK
ECCCHHHCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA