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The map label for this gene is lukD

Identifier: 161510040

GI number: 161510040

Start: 1956068

End: 1957051

Strand: Reverse

Name: lukD

Synonym: USA300HOU_1817

Alternate gene names: 161510040

Gene position: 1957051-1956068 (Counterclockwise)

Preceding gene: 161510041

Following gene: 161510039

Centisome position: 68.12

GC content: 31.91

Gene sequence:

>984_bases
ATGAAAATGAAAAAATTAGTCAAATCATCAGTTGCTTCATCAATTGCACTGCTTTTGCTATCGAATACAGTTGATGCAGC
TCAACATATCACACCTGTAAGCGAGAAAAAAGTAGATGACAAAATCACTTTATACAAAACAACAGCAACATCTGATAATG
ATAAATTGAATATTTCTCAAATTTTAACGTTTAATTTCATTAAGGATAAAAGTTATGACAAAGATACGTTAGTACTTAAG
GCAGCCGGAAACATTAATTCAGGTTATAAAAAGCCTAATCCAAAAGATTACAATTACTCACAGTTTTATTGGGGCGGTAA
GTATAATGTTTCGGTTAGTTCAGAATCAAATGATGCTGTAAATGTTGTTGACTATGCACCTAAAAATCAAAATGAAGAAT
TCCAAGTTCAACAAACATTAGGTTATTCTTATGGCGGAGATATTAATATATCTAATGGCTTATCAGGTGGATTAAATGGA
TCAAAATCATTTTCAGAAACGATAAATTATAAACAAGAAAGTTACAGAACTACGATTGATAGAAAAACAAATCATAAATC
AATTGGCTGGGGTGTTGAGGCGCACAAAATTATGAATAATGGTTGGGGACCATATGGTAGAGATAGTTATGACCCAACAT
ATGGTAATGAACTGTTTTTAGGCGGTAGACAAAGTAGTTCAAATGCTGGTCAAAATTTCTTGCCAACACATCAAATGCCT
TTATTGGCGCGTGGTAACTTTAACCCAGAATTTATAAGCGTACTTTCTCATAAACAAAATGATACAAAAAAATCTAAAAT
CAAAGTAACTTACCAAAGAGAAATGGATAGATATACTAATCAATGGAATCGACTACACTGGGTTGGTAATAACTACAAAA
ATCAAAATACAGTAACGTTTACATCTACTTATGAAGTTGACTGGCAAAACCATACTGTTAAATTAATCGGTACGGATTCT
AAAGAAACTAATCCTGGAGTATAA

Upstream 100 bases:

>100_bases
GCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAGTTAGATATGAAGTTAATTGGAAAACACACGAAATTAA
AGTGAAAGGACATAATTAAT

Downstream 100 bases:

>100_bases
CTGTTAGAAATAGAGGAAGTTAAACCCGAAATTTAAGAGTTAAACAAAAAATATTCACAACATATTAAAAAAAGAAGTTA
CATTATTTGTTTAAACTAAC

Product: leukotoxin LukD

Products: NA

Alternate protein names: H-gamma-1; H-gamma-I

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV

Sequences:

>Translated_327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV
>Mature_327_residues
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQILTFNFIKDKSYDKDTLVLK
AAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAVNVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNG
SKSFSETINYKQESYRTTIDRKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTFTSTYEVDWQNHTVKLIGTDS
KETNPGV

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HLGB_STAAS (Q6G8A9)

Other databases:

- EMBL:   BX571857
- RefSeq:   YP_043864.1
- ProteinModelPortal:   Q6G8A9
- SMR:   Q6G8A9
- STRING:   Q6G8A9
- EnsemblBacteria:   EBSTAT00000022403
- GeneID:   2864425
- GenomeReviews:   BX571857_GR
- KEGG:   sas:SAS1748
- GeneTree:   EBGT00050000023901
- HOGENOM:   HBG216024
- OMA:   NPRDYDY
- ProtClustDB:   CLSK885717
- BioCyc:   SAUR282459:SAS1748-MONOMER
- GO:   GO:0019835
- GO:   GO:0009405
- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183
- PRINTS:   PR01468
- TIGRFAMs:   TIGR01002

Pfam domain/function: PF07968 Leukocidin; SSF56959 Leukocidin/Porin

EC number: NA

Molecular weight: Translated: 36889; Mature: 36889

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQ
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEEEECCCCCCCEEHHH
ILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAV
EEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCE
NVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTID
EEEECCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHC
RKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTF
EEEECCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCCCCCEEEE
TSTYEVDWQNHTVKLIGTDSKETNPGV
EEEEEEECCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKMKKLVKSSVASSIALLLLSNTVDAAQHITPVSEKKVDDKITLYKTTATSDNDKLNISQ
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEEEECCCCCCCEEHHH
ILTFNFIKDKSYDKDTLVLKAAGNINSGYKKPNPKDYNYSQFYWGGKYNVSVSSESNDAV
EEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCEEEEEECCCCCCCE
NVVDYAPKNQNEEFQVQQTLGYSYGGDINISNGLSGGLNGSKSFSETINYKQESYRTTID
EEEECCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHHC
RKTNHKSIGWGVEAHKIMNNGWGPYGRDSYDPTYGNELFLGGRQSSSNAGQNFLPTHQMP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCC
LLARGNFNPEFISVLSHKQNDTKKSKIKVTYQREMDRYTNQWNRLHWVGNNYKNQNTVTF
EEEECCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHCCEEEEECCCCCCCCEEEE
TSTYEVDWQNHTVKLIGTDSKETNPGV
EEEEEEECCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA