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The map label for this gene is msrA2

Identifier: 161509591

GI number: 161509591

Start: 1463204

End: 1463737

Strand: Reverse

Name: msrA2

Synonym: USA300HOU_1361

Alternate gene names: 161509591

Gene position: 1463737-1463204 (Counterclockwise)

Preceding gene: 161509592

Following gene: 161509590

Centisome position: 50.95

GC content: 35.96

Gene sequence:

>534_bases
ATGACAAAAGAATATGCAACATTAGCAGGAGGATGTTTCTGGTGCATGGTTAAACCATTTACATCATATCCAGGCATCAA
GTCAGTCGTATCTGGTTATAGTGGCGGTCATGTTGACAACCCAACTTATGAACAGGTATGTACGAATCAAACCGGCCATG
TCGAAGCAGTACAAATTACGTTTGATCCAGAGGTTACTTCCTTTGAAAATATATTAGACATATATTTCAAAACATTTGAC
CCAACTGATGATCAAGGGCAATTTTTCGATAGAGGCGAAAGCTATCAACCAGTCATTTTCTATCATGATGAACATCAGAA
AAAGGCTGCTGAGTTTAAAAAGCAACAATTAAATGAACAAGGTATTTTCAAGAAACCAGTGATTACACCTATTAAACCAT
ATAAAAATTTCTATCCAGCTGAAGACTACCATCAAGATTATTACAAAAAGAACCCGGTACATTATTACCAATATCAACGT
GGTTCAGGTAGAAAAGCGTTTATAGAATCACATTGGGGGAATCAAAATGCTTAA

Upstream 100 bases:

>100_bases
GTCCTTAAGAAGTAAATTTAATCTTTTCAGTGTTAATTACTTCCATTTCAATCCTTTATAGACTAAATTTATAATTAGAT
AGATAGAGGAGGTAATTCAT

Downstream 100 bases:

>100_bases
AAAAGATAAAAGTGAACTAACAGATATAGAATATATTGTTACACAAGAAAACGGCACTGAACCACCATTTATGAATGAAT
ATTGGAATCATTTTGCTAAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQITFDPEVTSFENILDIYFKTFD
PTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQR
GSGRKAFIESHWGNQNA

Sequences:

>Translated_177_residues
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQITFDPEVTSFENILDIYFKTFD
PTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQR
GSGRKAFIESHWGNQNA
>Mature_176_residues
TKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQITFDPEVTSFENILDIYFKTFDP
TDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRG
SGRKAFIESHWGNQNA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.8205128205128, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=37.8205128205128, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=152, Percent_Identity=34.2105263157895, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=37.5, Blast_Score=110, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=33.1034482758621, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=34.3949044585987, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=34.8993288590604, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=34.2281879194631, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=34.5323741007194, Blast_Score=83, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA2_STAA8 (P0A086)

Other databases:

- EMBL:   AF349112
- EMBL:   CP000253
- RefSeq:   YP_499957.1
- ProteinModelPortal:   P0A086
- SMR:   P0A086
- STRING:   P0A086
- EnsemblBacteria:   EBSTAT00000028483
- GeneID:   3920213
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_01432
- eggNOG:   COG0225
- GeneTree:   EBGT00050000024265
- HOGENOM:   HBG748152
- OMA:   SIFPYEK
- ProtClustDB:   PRK13014
- BioCyc:   SAUR93061:SAOUHSC_01432-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 20588; Mature: 20457

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQIT
CCCCHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
ECCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGHVDNPTYEQVCTNQTGHVEAVQIT
CCCHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
ECCCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11700354; 11779133