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The map label for this gene is msrA1

Identifier: 161509527

GI number: 161509527

Start: 1398126

End: 1398635

Strand: Reverse

Name: msrA1

Synonym: USA300HOU_1295

Alternate gene names: 161509527

Gene position: 1398635-1398126 (Counterclockwise)

Preceding gene: 161509530

Following gene: 161509521

Centisome position: 48.68

GC content: 33.92

Gene sequence:

>510_bases
ATGAATATTAATACAGCTTATTTTGCCGGAGGTTGCTTTTGGTGTATGACGAAACCATTTGACACCTTTGACGGCATAGA
AAAAGTAACTTCTGGATATATGGGCGGACATATTGAAAATCCTACTTACGAACAAGTAAAATCAGGTACGAGTGGTCATT
TAGAAACTGTTGAAATTCAATATGATGTTGCATTATTCTCATACAATAAGTTATTAGAAATATTTTTCTCAGTCATTGAC
CCATTAGATACAGGTGGTCAATATCAAGACCGTGGTCCTCAATATCAAACAGCTATTTTCTACACTAATGATCATCAAAA
AGAACTCGCTGAGACTTATATCGAGCAGCTTAAAAATACGATTAATGCTGATAAGGCAATTGCAACAAAAATATTACCAG
CGTCACAATTTTACAAAGCCGAAGACTATCACCAAGATTTTTATAAGAAAAATCCAGAGCGCTATGCAGAAGAACAAAAA
ATACGCCAAGAATACAAAAATAAGCAATAA

Upstream 100 bases:

>100_bases
TGTACTATAATAATCACATATTAACGTTATATAAAAACAATTCAAAAAGCAAGTGATTTCTTAATAAATCGTACTAAGGT
CTAATGAAAGGATGTCAAAA

Downstream 100 bases:

>100_bases
CATTTATACTTGATGAAACTGATTGGACTGATAATAAAAGTTAGGCGACTTAACTTTAGCTCATTTCAATATTAAAATAC
GGTACAGATAGGAAACTTAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQYDVALFSYNKLLEIFFSVID
PLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNTINADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQK
IRQEYKNKQ

Sequences:

>Translated_169_residues
MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQYDVALFSYNKLLEIFFSVID
PLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNTINADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQK
IRQEYKNKQ
>Mature_169_residues
MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQYDVALFSYNKLLEIFFSVID
PLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNTINADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQK
IRQEYKNKQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=35.9477124183007, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=35.9477124183007, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI208609993, Length=151, Percent_Identity=31.1258278145695, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=39.2156862745098, Blast_Score=114, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=36.986301369863, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=32.2784810126582, Blast_Score=74, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=30.8724832214765, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45553131, Length=143, Percent_Identity=30.0699300699301, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=30.2013422818792, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA1_STAA8 (P0A084)

Other databases:

- EMBL:   AF311784
- EMBL:   CP000253
- RefSeq:   YP_499887.1
- ProteinModelPortal:   P0A084
- SMR:   P0A084
- STRING:   P0A084
- EnsemblBacteria:   EBSTAT00000028213
- GeneID:   3920065
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_01360
- eggNOG:   COG0225
- GeneTree:   EBGT00050000024265
- HOGENOM:   HBG748152
- OMA:   IFYTNED
- ProtClustDB:   PRK14054
- BioCyc:   SAUR93061:SAOUHSC_01360-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19611; Mature: 19611

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
CCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
EHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHH
INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNINTAYFAGGCFWCMTKPFDTFDGIEKVTSGYMGGHIENPTYEQVKSGTSGHLETVEIQ
CCCCCEEECCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
YDVALFSYNKLLEIFFSVIDPLDTGGQYQDRGPQYQTAIFYTNDHQKELAETYIEQLKNT
EHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHH
INADKAIATKILPASQFYKAEDYHQDFYKKNPERYAEEQKIRQEYKNKQ
HCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA