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The map label for this gene is argH [H]

Identifier: 161509160

GI number: 161509160

Start: 956020

End: 957399

Strand: Reverse

Name: argH [H]

Synonym: USA300HOU_0919

Alternate gene names: 161509160

Gene position: 957399-956020 (Counterclockwise)

Preceding gene: 161509161

Following gene: 161509159

Centisome position: 33.33

GC content: 34.49

Gene sequence:

>1380_bases
ATGAGCAATAAAGCTTGGGGCGGTAGATTTGAAGTACAACCTGAAGAGTGGGTTGACGACTTTAACGCATCCATTACTTT
TGATCAAACGCTCATAGATCAAGATATCGAAGGCAGCATTGCACATGCAACTATGCTTGCGAATCAAGGCATTATTAGTC
AACAAGACAGCGAACAAATTATACAAGGACTAAAATCTATTCAACATGATTATCATCAAGATCAAATTCAATTTAGTGCA
TCATTAGAAGATATTCATTTAAATATTGAACATGAATTAATTAAACGTATCGGTGATGCTGGTGGTAAGTTGCATACTGG
ACGCAGTAGAAACGATCAAGTTGCAACAGACATGCACTTGTACACTAAGAAACAAGTGCAAGATATCATCGCATTAATTA
AGTCGTTACAAAGTGTAATTGTAGACATCGCTTCCAATAATGTTGATACAATTATGCCTAGTTATACTCATTTACAGCGT
GCACAGCCAATTTCATTTGCACATCATATTATGACTTATTTTTGGATGTTACAACGAGACCAACAACGATTTGAAGATAG
TTTAAAACGAATCGATATTAATCCTTTAGGTGCAGCAGCCTTAAGTGGTACCACATACCCTATCGATAGACACGAGACAA
CAGCATTGTTGAACTTTGGCAGTCTCTATGAGAATAGCCTAGATGCTGTTAGTGACAGAGACTATATTATTGAAACATTG
CATAATATTTCTTTAACGATGGTTCACTTATCACGCTTTGCAGAGGAAATTATTTTCTGGTCCACAGACGAAGCTAAATT
CATTACATTATCAGATGCATTTTCAACTGGCTCATCTATTATGCCACAAAAGAAAAATCCTGATATGGCAGAATTAATTA
GAGGTAAAGTTGGTCGAACGACTGGTCATTTAATGAGCATGCTTATGACTTTAAAAGGATTACCTCTAGCATATAACAAA
GATATGCAGGAAGATAAAGAAGGTTTATTCGATGCTGTCCATACAATTAAAGGTTCTTTACGTATTTTCGAAGGTATGAT
TCAAACGATGACAATTAATAAAGAACGACTCAATCAAACTGTTAAAGAAGATTTTTCAAATGCAACGGAACTAGCAGATT
ATTTAGTAACTAAAAATATTCCATTTAGAACTGCACATGAAATTGTAGGAAAAATCGTCTTAGAATGTATACAACAAGGT
CATTATTTATTAGATGTTCCTTTAGCAACATATCAACAACATCATTCTAGTATTGATGCCGATATTTACGATTATTTGCA
GCCTGAAAATTGTTTAAAACGACGTCAAAGTTACGGTTCAACAGGTCAATCATCGGTCAAACAACAACTTGATGTTGCTA
AACAATTACTATCACAATAA

Upstream 100 bases:

>100_bases
ACAAAAGAAGATGCATTTAATCAAGACGCTGCTGTTGGCTTTATCGATATCTATGGTTTACCTACTCAAGTAAATGCGAT
GTTGCATGGAGGCTATAGCA

Downstream 100 bases:

>100_bases
ATACGTTAATCTACCTACCCACAATGTCTATTAAAATTACATTGTGGGTATTTTAATGCTCTCTTCGTCTTGTTGAACAT
CACATTTTTAAGATTCCTAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSA
SLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQR
AQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNK
DMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQG
HYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ

Sequences:

>Translated_459_residues
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSA
SLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQR
AQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNK
DMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQG
HYLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
>Mature_458_residues
SNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQFSAS
LEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQRA
QPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETLH
NISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKD
MQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQTVKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGH
YLLDVPLATYQQHHSSIDADIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=456, Percent_Identity=41.8859649122807, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303542, Length=456, Percent_Identity=41.8859649122807, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI68303549, Length=456, Percent_Identity=40.3508771929825, Blast_Score=335, Evalue=7e-92,
Organism=Homo sapiens, GI68303547, Length=456, Percent_Identity=39.0350877192982, Blast_Score=327, Evalue=1e-89,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=47.7973568281938, Blast_Score=452, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6321806, Length=460, Percent_Identity=42.6086956521739, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221473854, Length=452, Percent_Identity=36.5044247787611, Blast_Score=330, Evalue=2e-90,
Organism=Drosophila melanogaster, GI78706858, Length=452, Percent_Identity=36.5044247787611, Blast_Score=330, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 52048; Mature: 51916

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQI
CCCCCCCCEEECCHHHHHHCCCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHH
IQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHL
HHHHHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
YTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQRAQPISFAHHIMTYFWMLQRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
QQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRT
HHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCH
TGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDA
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCH
DIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
HHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SNKAWGGRFEVQPEEWVDDFNASITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQI
CCCCCCCEEECCHHHHHHCCCCCEEECHHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHH
IQGLKSIQHDYHQDQIQFSASLEDIHLNIEHELIKRIGDAGGKLHTGRSRNDQVATDMHL
HHHHHHHHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
YTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPSYTHLQRAQPISFAHHIMTYFWMLQRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
QQRFEDSLKRIDINPLGAAALSGTTYPIDRHETTALLNFGSLYENSLDAVSDRDYIIETL
HHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHH
HNISLTMVHLSRFAEEIIFWSTDEAKFITLSDAFSTGSSIMPQKKNPDMAELIRGKVGRT
HHHHHHHHHHHHHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHCCCCCH
TGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAVHTIKGSLRIFEGMIQTMTINKERLNQT
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VKEDFSNATELADYLVTKNIPFRTAHEIVGKIVLECIQQGHYLLDVPLATYQQHHSSIDA
HHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCH
DIYDYLQPENCLKRRQSYGSTGQSSVKQQLDVAKQLLSQ
HHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA