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The map label for this gene is gcvR [H]

Identifier: 161486816

GI number: 161486816

Start: 438899

End: 439471

Strand: Reverse

Name: gcvR [H]

Synonym: t0369

Alternate gene names: 161486816

Gene position: 439471-438899 (Counterclockwise)

Preceding gene: 29140902

Following gene: 29140895

Centisome position: 9.17

GC content: 50.26

Gene sequence:

>573_bases
TTGACACCGTCATCACAACACTATTTGGTTATCACTGCGCTGGGCGCCGACAGGCCCGGTATTGTGAATACCATTACTCG
CCATGTCAGCAGTTGCGGCTGTAATATCGAAGACAGCCGACTGGCGATGCTGGGCGATGAATTCACGTTTATTATGCTGT
TGTCCGGCACGTGGAACGCGATTACCTTGATTGAATCGACATTGCCGTTAAAAGGCGCGGAGCTGGATCTGCTGATTGTG
ATGAAACGGACGTCCGACCGCCCCCGCCCGGCAATGCCCGCGACGGTATGGGTTCAGGTTGAGGTCGCCGACTCCCCGCA
TTTAATTGAGCGATTCACCGCGCTGTTTAATAGTCATGAAATGAATATTGCGGAGCTGGTCTCCCGCACGCAGCCGGCTG
AAGATGATAAAGCTGCGCAATTATTTATTCAAATCACCGCACATAGCCCGGCGTCGCAAAATTCCGCAAATATTGAGCAA
GCCTTTAAAGCACTATGTACAGAACTCAATGCGCAAGGCAGTATAAACGTCGTCAATTACTCACAACATGATGAACAGGA
TGGAGTTAAGTAA

Upstream 100 bases:

>100_bases
TGACAATAAAAGCAAGCGACCAAAGCCGTTCTGATTGTTGTATGCAGGTTTTTTTTATGGTTTCCTTAAGATTACCTCAC
CGCTCAAAGGAATAACTGGT

Downstream 100 bases:

>100_bases
TGAATCCACTGAAAGCCGGTGATATCGCACCGAAATTTAGCTTGCCGGATCAAGACGGGGAACAAGTAAATTTGACCGAC
TTCCAGGGGCAGCGCGTTCT

Product: glycine cleavage system transcriptional repressor

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGTWNAITLIESTLPLKGAELDLLIV
MKRTSDRPRPAMPATVWVQVEVADSPHLIERFTALFNSHEMNIAELVSRTQPAEDDKAAQLFIQITAHSPASQNSANIEQ
AFKALCTELNAQGSINVVNYSQHDEQDGVK

Sequences:

>Translated_190_residues
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGTWNAITLIESTLPLKGAELDLLIV
MKRTSDRPRPAMPATVWVQVEVADSPHLIERFTALFNSHEMNIAELVSRTQPAEDDKAAQLFIQITAHSPASQNSANIEQ
AFKALCTELNAQGSINVVNYSQHDEQDGVK
>Mature_189_residues
TPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGTWNAITLIESTLPLKGAELDLLIVM
KRTSDRPRPAMPATVWVQVEVADSPHLIERFTALFNSHEMNIAELVSRTQPAEDDKAAQLFIQITAHSPASQNSANIEQA
FKALCTELNAQGSINVVNYSQHDEQDGVK

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=190, Percent_Identity=90.5263157894737, Blast_Score=361, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 20833; Mature: 20702

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGTWNA
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
ITLIESTLPLKGAELDLLIVMKRTSDRPRPAMPATVWVQVEVADSPHLIERFTALFNSHE
EEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
MNIAELVSRTQPAEDDKAAQLFIQITAHSPASQNSANIEQAFKALCTELNAQGSINVVNY
CCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
SQHDEQDGVK
CCCCCCCCCC
>Mature Secondary Structure 
TPSSQHYLVITALGADRPGIVNTITRHVSSCGCNIEDSRLAMLGDEFTFIMLLSGTWNA
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEECCCCE
ITLIESTLPLKGAELDLLIVMKRTSDRPRPAMPATVWVQVEVADSPHLIERFTALFNSHE
EEEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHCCCC
MNIAELVSRTQPAEDDKAAQLFIQITAHSPASQNSANIEQAFKALCTELNAQGSINVVNY
CCHHHHHHHCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
SQHDEQDGVK
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]