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The map label for this gene is uvrC [H]

Identifier: 161486699

GI number: 161486699

Start: 685090

End: 687162

Strand: Reverse

Name: uvrC [H]

Synonym: BR0699

Alternate gene names: 161486699

Gene position: 687162-685090 (Counterclockwise)

Preceding gene: 23501587

Following gene: 23501585

Centisome position: 32.6

GC content: 59.62

Gene sequence:

>2073_bases
ATGGCCACCCGCAAGACAACCACCGGCGAGCAAACGCATCTGCCGCCCGATGACGAACAGGACGTTGCGGGCATCATTAT
CGGTGAGGCAGAAACCGAAGACGATGACGATGCGGCGGCAAACGGCGAGGAAGAGCCTGCCCGCATAGCTTCGGCTGCGG
AATCCATCCAGTGGGATTCGTCGGACGGGCTGCCCGATACGGCGGGGCTCAGCGGCCCGGACATCATCAATGCCTTTATG
AAGCGCCTGCCCAACAATCCCGGTGTCTATCGCATGTTCAACAGCGATGGAGACGTGCTTTATGTCGGCAAGGCGCGCAA
CCTCAAGAAGCGCGTTTCCAATTATGCGCGCGGCATTGGCCATTCCAATCGCATCACACGCATGATCCGTGAAACCGTGA
CGATGGAATTCGTCGTCACGCGCACGGAAACGGAAGCACTTCTGCTTGAAGCAAATCTCATCAAAAGATCGCGGCCACGC
TTCAACGTGCTGATGCGCGACGACAAGTCGTTTCCGTATATTCTGCTGACCGGCGGCCACCGCGCGCCGGGCATTTTCAA
GCATCGCGGCGCACGTTCGCGCAAGGGCGACTATTTCGGCCCCTTTGCTTCGGCGGGGGCTGTGGGCCGCACCATCAACG
CGCTCCAGCGCGCTTTTTTACTGCGCACCTGCACCGATTCCGTCTTTGAAACCCGCACACGGCCCTGCCTGCTCTATCAG
ATCAAACGCTGCTCTGCGCCCTGCACCTATGAAATCAGCGACGAGGACTATGCCGGGCTTGTGGCAGAGGCCAAGGCCTT
TCTTTCCGGCAAGAGCCAGTCGGTCAAGGATCATCTGGCAGCGGCAATGCAGGCAGCTTCCGCCGATCTCGATTTTGAAC
ATGCCGCAGTCTATCGCGACCGTCTCGCCGCGCTTTCACACGTCCAGTCCCATCAGGGTATCAATCCGCAAACGGTCGAG
GAAGCCGATGTTTTCGCCATCCATCAGGAAGGCGGCATGACCTGCATTCAGGTCTTCTTCTTCCGCACCGGCCAGAACTG
GGGCAACCGCGCCTATTTTCCGAAAGCCGACAGTTCGCTCGGGCCAGCGGAAGTGCTGGGCGCTTTCCTGTCGCAGTTCT
ATGATGACAAGCCTTGCCCGAAACTCGTTCTCCTTTCGGAAACGGTCGAAGAACAATCCCTTATCACCGAGGCGCTCTCC
ACGCGCGCCGGTCATAAGGTCCAGGTCTCGGTGCCGCAGCGCGGTGAAAAGAAAGAACTCGTGCAGCACGCGCTGACCAA
TGCGCGCGAAGCACTTGGCCGCAGGCTGGCCGAAACCTCATCGCAGGCGCGCTTGCTACAGGGGCTTGCCGAAACATTCG
GCCTGCCGCGCGCACCGCGCCGCATCGAGGTTTACGACAATTCCCACATCATGGGCACCAATGCGGTTGGCGGCATGATC
GTCGCCGGGCCGGAAGGCTTTGTGAAAAACCAGTATCGCAAGTTCAATATCCGTTCGACCGACATTACGCCGGGCGATGA
TTTCGGCATGATGCGGGAGGTGATCGAGCGGCGCTTCTCACGTCTGGTAAAGGAACATGGAACCCCTGCCGGCGAGGTGG
AGAACCCGGACGCCTTCCCTGCCTGGCCTGATGTCATTCTCATTGATGGTGGCCAGGGACAGGTGGGCGCGGTGCGCCAG
ATACTCGGCGAGATGGGCATCAGCGATCTGGTCACGGCAATCGGCATCGCCAAGGGCGTTGACCGCGAGGCAGGCCGCGA
GCGGTTTTTCATGGAAGGCAAGCAGCCATTTACCCTGCCCCCGCGCGATCCCGTTCTTTATTTCATCCAACGCCTGCGCG
ACGAGGCGCATCGCTTTGCCATAGGCACCCACCGCGCACGACGCAAGAAGGAAATGGTCAGGAATCCGCTGGATGAAATT
GCCGGCATAGGCCCTACGCGCAAGCGCGCCCTTTTACATCATTTTGGAACGGCAAAAGCGGTTTCGCGCGCCGCTGTCGA
AGATCTGATGCAAATCGATGGTATTTCGGAAGCCATGGCGCGGGCGATCCACGACCACTTCCGGGACAAATGA

Upstream 100 bases:

>100_bases
ATTTCTGGGAAAACCGTTCCATTACCGGCCAGATGATTGCGCTCGACGGCGGGCAGCACCTGGCATGGGAAACGCCCGAC
ATTGCAGGAATTACCGAATA

Downstream 100 bases:

>100_bases
CGTGATTTTGTATAATTTGGACATATTAGCGACGTTAGATTCCAGCATAACATATTCGCAGGTGTTGATTTTCTCCGTCA
TCCCTGTTGATGTGCCATCA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MATRKTTTGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFM
KRLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPR
FNVLMRDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQ
IKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVE
EADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALS
TRAGHKVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMI
VAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFPAWPDVILIDGGQGQVGAVRQ
ILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEI
AGIGPTRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK

Sequences:

>Translated_690_residues
MATRKTTTGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFM
KRLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPR
FNVLMRDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQ
IKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVE
EADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALS
TRAGHKVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMI
VAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFPAWPDVILIDGGQGQVGAVRQ
ILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEI
AGIGPTRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK
>Mature_689_residues
ATRKTTTGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDSSDGLPDTAGLSGPDIINAFMK
RLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPRF
NVLMRDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQI
KRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEE
ADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALST
RAGHKVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIV
AGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFPAWPDVILIDGGQGQVGAVRQI
LGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEIA
GIGPTRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=616, Percent_Identity=39.4480519480519, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1788037, Length=191, Percent_Identity=29.8429319371728, Blast_Score=76, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 76272; Mature: 76141

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRKTTTGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDS
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SDGLPDTAGLSGPDIINAFMKRLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIG
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHCCC
HSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPRFNVLMRDDKSFPYILLTGGH
CHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCC
RAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQ
CCCCHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRD
HHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RLAALSHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSL
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCC
GPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKEL
CHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
VQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEE
VAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFP
EECCCHHHHCCCEEEECEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AWPDVILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLP
CCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCHHHHHCCCCCCCCCC
PRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEIAGIGPTRKRALLHHFGTAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHH
VSRAAVEDLMQIDGISEAMARAIHDHFRDK
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATRKTTTGEQTHLPPDDEQDVAGIIIGEAETEDDDDAAANGEEEPARIASAAESIQWDS
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
SDGLPDTAGLSGPDIINAFMKRLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIG
CCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCHHHHHHHHHHHHCCC
HSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPRFNVLMRDDKSFPYILLTGGH
CHHHHHHHHHHHHHEEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCC
RAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQ
CCCCHHHHCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
IKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRD
HHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
RLAALSHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSL
HHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEHHHHHHHCCCCCCCCCCCCCCCCCC
GPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKEL
CHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
VQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEECCCCCCEE
VAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFP
EECCCHHHHCCCEEEECEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AWPDVILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLP
CCCCEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHCHHHHHCCCCCCCCCC
PRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEIAGIGPTRKRALLHHFGTAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHH
VSRAAVEDLMQIDGISEAMARAIHDHFRDK
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA