Click here to switch to the map view.

The map label for this gene is atpB-2

Identifier: 161485733

GI number: 161485733

Start: 18473

End: 19531

Strand: Reverse

Name: atpB-2

Synonym: CT0021

Alternate gene names: 161485733

Gene position: 19531-18473 (Counterclockwise)

Preceding gene: 21672864

Following gene: 21672861

Centisome position: 0.91

GC content: 56.56

Gene sequence:

>1059_bases
ATGCGAAAGAAAGCGATTTCAAGAATTCTGGCACTGGTCGTGCCTGTTCTCCTGAGCCTGAACAGCCAAGCATTCGCCAC
TTCCGTCCAGGATGAGTCTCCGGTAACGGGCTCCGCGGTCGAAGCCGTTCACACTGTGCCGTCAACCGTCGCGGCGCCAG
TCGCCGGACACGCCGAAGCCGCTGCCGGTCAGGCCGCCAAGGCTGAAGAGAAGCCGGGCGACCTCATCATGCACCACATT
CTCGATAACAGCACCTTCTCTTTCGAGCCGTTCGGTGAGGTGCATCTTCCCCATCTCGAAGTCGCCGGTTTCGATATTTC
GATCACCAAGCATGTGGTGATGATCTGGCTTGCCGCGATCCTGCTGGTCGTTATCGCAAGTGCTGCCGGCGCGAGCGTCA
AGAAGATGTCCGCAAATCAGGCGCCGAAGGGTGTTGCCAACGTTTTCGAGTCACTGGTCGATTTTATCAGCAATGACGTC
GCCAAACCCAACATCGGTCACGGTTACGAAAAGTTCCTGCCCTACCTGCTGACGGTGTTCTTTTTCATTCTGGTTTGCAA
TCTGCTCGGCCTCATCCCTTATGGCGCGACCGCGACCGGCAACATCAACGTTACGCTTACCCTCTCGGTTTTCACCTTTG
TCATCACCCAGTTCTCGGCATTCAAGGCCCAGGGCGTCAAAGGTTATCTTCAGCACCTAACCGCAGGAACGCACTGGGCG
CTCTGGATTATCATGGTGCCAATCGAAATTCTCGGCCAGTTCACCAAGCCGTTCGCACTGACCATCCGACTCTTCGCGAA
CATGACGGCGGGCCATATCATCATTCTCAGCCTGTTCTTCATCAGCTTCATCCTGAAGAGCTACATCGTAGCTGTGGCGG
TGTCGATTCCGTTCGCGATCTTTATCTATCTGCTCGAGCTCTTCGTTGCGTTCCTGCAGGCGTACGTTTTCACCATGCTC
TCGGCGCTCTTCATCGGCTTGGCCACGGCGCACTCCGACAGCCACGACGGCCACGAGCTGGAGGCTACCGCTCGTCATGG
AGACGGGCTGACGGTTTGA

Upstream 100 bases:

>100_bases
CTTCATCTCTTTTTACTGTATTTATCTGGTGCTCGAGATTCTCGCTTACCAGAAGAAGAATCAACTGAAAAAAAACGCGG
CAAAAAACTGACAAGACGGT

Downstream 100 bases:

>100_bases
CGAGTTTTATGTATCGATGATTTTAGAACTGCTACAAGAAGTAGCATTCATTTTACAACAACAATCAATGGAGGCAATTT
AAAGATGGAAGGTTTGGGTT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a 2; F-ATPase subunit 6 2

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRKKAISRILALVVPVLLSLNSQAFATSVQDESPVTGSAVEAVHTVPSTVAAPVAGHAEAAAGQAAKAEEKPGDLIMHHI
LDNSTFSFEPFGEVHLPHLEVAGFDISITKHVVMIWLAAILLVVIASAAGASVKKMSANQAPKGVANVFESLVDFISNDV
AKPNIGHGYEKFLPYLLTVFFFILVCNLLGLIPYGATATGNINVTLTLSVFTFVITQFSAFKAQGVKGYLQHLTAGTHWA
LWIIMVPIEILGQFTKPFALTIRLFANMTAGHIIILSLFFISFILKSYIVAVAVSIPFAIFIYLLELFVAFLQAYVFTML
SALFIGLATAHSDSHDGHELEATARHGDGLTV

Sequences:

>Translated_352_residues
MRKKAISRILALVVPVLLSLNSQAFATSVQDESPVTGSAVEAVHTVPSTVAAPVAGHAEAAAGQAAKAEEKPGDLIMHHI
LDNSTFSFEPFGEVHLPHLEVAGFDISITKHVVMIWLAAILLVVIASAAGASVKKMSANQAPKGVANVFESLVDFISNDV
AKPNIGHGYEKFLPYLLTVFFFILVCNLLGLIPYGATATGNINVTLTLSVFTFVITQFSAFKAQGVKGYLQHLTAGTHWA
LWIIMVPIEILGQFTKPFALTIRLFANMTAGHIIILSLFFISFILKSYIVAVAVSIPFAIFIYLLELFVAFLQAYVFTML
SALFIGLATAHSDSHDGHELEATARHGDGLTV
>Mature_352_residues
MRKKAISRILALVVPVLLSLNSQAFATSVQDESPVTGSAVEAVHTVPSTVAAPVAGHAEAAAGQAAKAEEKPGDLIMHHI
LDNSTFSFEPFGEVHLPHLEVAGFDISITKHVVMIWLAAILLVVIASAAGASVKKMSANQAPKGVANVFESLVDFISNDV
AKPNIGHGYEKFLPYLLTVFFFILVCNLLGLIPYGATATGNINVTLTLSVFTFVITQFSAFKAQGVKGYLQHLTAGTHWA
LWIIMVPIEILGQFTKPFALTIRLFANMTAGHIIILSLFFISFILKSYIVAVAVSIPFAIFIYLLELFVAFLQAYVFTML
SALFIGLATAHSDSHDGHELEATARHGDGLTV

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=283, Percent_Identity=24.3816254416961, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP62_CHLTE (Q8KGE7)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_660927.2
- HSSP:   P68699
- GeneID:   1006288
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT0021
- NMPDR:   fig|194439.1.peg.21
- TIGR:   CT0021
- HOGENOM:   HBG734175
- OMA:   DISITKH
- ProtClustDB:   PRK13419
- BioCyc:   CTEP194439:CT_0021-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 37819; Mature: 37819

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb1a7af0)-; HASH(0xba655f0)-; HASH(0xb646ac0)-; HASH(0xb642244)-; HASH(0xb642394)-; HASH(0xb264490)-; HASH(0xb63da18)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKAISRILALVVPVLLSLNSQAFATSVQDESPVTGSAVEAVHTVPSTVAAPVAGHAEA
CCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHCCCCCHHH
AAGQAAKAEEKPGDLIMHHILDNSTFSFEPFGEVHLPHLEVAGFDISITKHVVMIWLAAI
HCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
LLVVIASAAGASVKKMSANQAPKGVANVFESLVDFISNDVAKPNIGHGYEKFLPYLLTVF
HHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FFILVCNLLGLIPYGATATGNINVTLTLSVFTFVITQFSAFKAQGVKGYLQHLTAGTHWA
HHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LWIIMVPIEILGQFTKPFALTIRLFANMTAGHIIILSLFFISFILKSYIVAVAVSIPFAI
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIYLLELFVAFLQAYVFTMLSALFIGLATAHSDSHDGHELEATARHGDGLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHCCCCCCCH
>Mature Secondary Structure
MRKKAISRILALVVPVLLSLNSQAFATSVQDESPVTGSAVEAVHTVPSTVAAPVAGHAEA
CCHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHCHHHHHHCCCCCHHH
AAGQAAKAEEKPGDLIMHHILDNSTFSFEPFGEVHLPHLEVAGFDISITKHVVMIWLAAI
HCCCHHCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHH
LLVVIASAAGASVKKMSANQAPKGVANVFESLVDFISNDVAKPNIGHGYEKFLPYLLTVF
HHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FFILVCNLLGLIPYGATATGNINVTLTLSVFTFVITQFSAFKAQGVKGYLQHLTAGTHWA
HHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LWIIMVPIEILGQFTKPFALTIRLFANMTAGHIIILSLFFISFILKSYIVAVAVSIPFAI
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIYLLELFVAFLQAYVFTMLSALFIGLATAHSDSHDGHELEATARHGDGLTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12093901