Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is tkt [H]

Identifier: 161378148

GI number: 161378148

Start: 1389971

End: 1391956

Strand: Reverse

Name: tkt [H]

Synonym: SPy_1676

Alternate gene names: 161378148

Gene position: 1391956-1389971 (Counterclockwise)

Preceding gene: 15675540

Following gene: 15675538

Centisome position: 75.14

GC content: 44.96

Gene sequence:

>1986_bases
ATGACATTTGATGCAATTGACCAGTTGGCAGTAAACACTGTCCGCACCCTATCAATGGATGCCATTCAAGCGGCAAATTC
TGGACACCCAGGACTTCCAATGGGGGCAGCACCTATGGCCTATGTTCTTTGGAATCACTTCATGAACATCAATCCCAAAA
CAAGCCGTAATTGGTCAAACAGAGACCGTTTTATCCTATCAGCAGGTCATGGAAGTGCCATGCTTTATAGCTTGTTACAC
TTAGCTGGTTATGATTTATCTGTAGAAGATTTAAAGAACTTCCGTCAATGGGGTTCTAAAACACCAGGTCACCCAGAAGT
GAACCACACAGACGGTGTCGAAGCAACCACAGGACCTCTTGGTCAAGGGATCGCAAATGCCGTTGGGATGGCCATGGCAG
AAGCTCATCTAGCAGCTAAATTTAACAAACCAGGCTTTGACATCGTTGATCACTACACATTTGCTTTGAATGGTGACGGT
GACCTTATGGAAGGGGTCAGCCAAGAAGCAGCAAGTATGGCAGGACATTTAAAACTTGGGAAATTGGTCTTGCTATATGA
TTCAAACGACATCTCTCTTGATGGTCCAACCTCTATGGCTTTCACAGAAGATGTGAAAGGACGTTTCGAAGCTTATGGTT
GGCAACATATCCTTGTGAAAGATGGAAATGATTTAGAAGAAATTGCAGCTGCTATTGAAGCAGCTAAAGCTGAAACTGAG
AAACCAACCATCATCGAAGTCAAAACCATTATTGGTTTTGGTGCCGAAAAACAAGGAACTTCAGCTGTTCACGGCGCTCC
TCTTGGAGCAGAAGGCATTGCTTTTGCCAAAAAAGCTTACCAATGGACTCATCAAGATTTTGAAGTGCCTGCTGAAGTAA
CAGAGCGCTTTGCTCAAGGTCTTCAAGCGCGTGGTGAAAAAGCAGAACAAGCCTGGAATGACTTGTTTGCAGCTTATGAA
GCAGAATATCCAGAATTAGCAGCAGAATACCAAAAAGCCTTTACTAACGAAGCTGCTCAAGTAGAACTTGAAGCGCACGA
ACTTGGTAGTTCAATGGCGAGTCGTGTATCCAGTCAACAAGCCATCCAACAAATTTCAGAACAAGTAGCCTCTTTCTGGG
GTGGGTCAGCAGACCTTTCAGCTTCAAACAATACTATGGTTAAGGCTGAAACAGATTTCCAACCAGGTCACTACGAAGGC
CGTAACATCTGGTTTGGCGTTCGTGAATTTGCCATGGCTGCAGCCATGAACGGTATTGCCCTTCACGGCGGGACACGCGT
TTACGGCGGAACCTTCTTTGTCTTCTCAAACTATCTTCTTCCAGCTGTTCGTATGGCAGCGCTCCAAAACTTGCCAACAG
TTTATGTCATGACACATGATTCTATCGCTGTCGGTGAAGATGGGCCAACGCACGAACCAATTGAACAATTGGCAAGTGTT
CGCTCAATGCCTAACTTGAACGTTATTCGTCCAGCAGACGGTAACGAAACAAATGCTGCTTGGAAACGTGCCATTGCTGA
AACAGATCGCCCAACCATGCTTGTATTGACGCGTCAAAACCTTCCAGTGCTTGAGGGCACAAAAGAATTGGCAGAAGATG
GTCTTAGCAAAGGAGCTTATATCTTGTCAGAAGCCAAAGGCGACCTTGATGGTATCTTGATTGCAACAGGTTCAGAAGTG
AAACTGGCAATGGATACTCAAGAAGCTCTTGAAGCAGAAGGCATTCATGTGCGTGTCGTATCTATGCCATCACAAAATAT
CTTTGACGAACAGTCAGCAGAGTATAAAGAAAGCATCCTACCAGCAGCTGTGACTAAACGTCTCGCTATCGAAGCAGGTT
CAAGCTTTGGCTGGGCAAAATATGTCGGCCTATCAGGAAAAACATTGACCATTGACACTTGGGGTGCTTCAGCTCCAGGA
AATCGTATCTTCGAAGAATATGGTTTCACTGTGGCAAATGCAACTGAGTTATACAAATCACTCTAA

Upstream 100 bases:

>100_bases
GGACTTTGGAGGATTTTCTGAAAAAAGCGTCTATTTTTGTGATACAATAGACAATAGAAAACGTTTAATTTTAGTTGTAA
TAAACAGAGAGGTTTTACTT

Downstream 100 bases:

>100_bases
GTTAAACATCCCAAACAGAGTAAATCATTTGATTTACTCTGTTTTTTTAAAATAAAATACCCAGTTCTTTCTTTTCCTCA
AACTGCCTAATACACTTCTT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MTFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSNRDRFILSAGHGSAMLYSLLH
LAGYDLSVEDLKNFRQWGSKTPGHPEVNHTDGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDG
DLMEGVSQEAASMAGHLKLGKLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETE
KPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQGLQARGEKAEQAWNDLFAAYE
AEYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQAIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEG
RNIWFGVREFAMAAAMNGIALHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASV
RSMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLSKGAYILSEAKGDLDGILIATGSEV
KLAMDTQEALEAEGIHVRVVSMPSQNIFDEQSAEYKESILPAAVTKRLAIEAGSSFGWAKYVGLSGKTLTIDTWGASAPG
NRIFEEYGFTVANATELYKSL

Sequences:

>Translated_661_residues
MTFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSNRDRFILSAGHGSAMLYSLLH
LAGYDLSVEDLKNFRQWGSKTPGHPEVNHTDGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDG
DLMEGVSQEAASMAGHLKLGKLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETE
KPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQGLQARGEKAEQAWNDLFAAYE
AEYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQAIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEG
RNIWFGVREFAMAAAMNGIALHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASV
RSMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLSKGAYILSEAKGDLDGILIATGSEV
KLAMDTQEALEAEGIHVRVVSMPSQNIFDEQSAEYKESILPAAVTKRLAIEAGSSFGWAKYVGLSGKTLTIDTWGASAPG
NRIFEEYGFTVANATELYKSL
>Mature_660_residues
TFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSNRDRFILSAGHGSAMLYSLLHL
AGYDLSVEDLKNFRQWGSKTPGHPEVNHTDGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDGD
LMEGVSQEAASMAGHLKLGKLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETEK
PTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQGLQARGEKAEQAWNDLFAAYEA
EYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQAIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEGR
NIWFGVREFAMAAAMNGIALHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASVR
SMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLSKGAYILSEAKGDLDGILIATGSEVK
LAMDTQEALEAEGIHVRVVSMPSQNIFDEQSAEYKESILPAAVTKRLAIEAGSSFGWAKYVGLSGKTLTIDTWGASAPGN
RIFEEYGFTVANATELYKSL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=578, Percent_Identity=28.5467128027682, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI4507521, Length=578, Percent_Identity=28.5467128027682, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=572, Percent_Identity=26.7482517482518, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI225637459, Length=260, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994911, Length=663, Percent_Identity=51.4328808446455, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=653, Percent_Identity=48.5451761102603, Blast_Score=604, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI17539652, Length=651, Percent_Identity=27.4961597542243, Blast_Score=160, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6325331, Length=660, Percent_Identity=48.030303030303, Blast_Score=604, Evalue=1e-173,
Organism=Saccharomyces cerevisiae, GI6319593, Length=662, Percent_Identity=46.3746223564955, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45551847, Length=572, Percent_Identity=27.972027972028, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45550715, Length=572, Percent_Identity=27.972027972028, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24666278, Length=575, Percent_Identity=26.9565217391304, Blast_Score=157, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24645119, Length=544, Percent_Identity=27.5735294117647, Blast_Score=155, Evalue=9e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71354; Mature: 71222

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
RDRFILSAGHGSAMLYSLLHLAGYDLSVEDLKNFRQWGSKTPGHPEVNHTDGVEATTGPL
CCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDGDLMEGVSQEAASMAGHLKLG
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEC
KLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETE
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCC
KPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQG
CCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQARGEKAEQAWNDLFAAYEAEYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQ
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHH
AIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEGRNIWFGVREFAMAAAMNGIA
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHCCEE
LHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASV
EECCCEEECCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHH
RSMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLSKGAY
HCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHCCCHHHHHCCCCCCEE
ILSEAKGDLDGILIATGSEVKLAMDTQEALEAEGIHVRVVSMPSQNIFDEQSAEYKESIL
EEECCCCCCCEEEEECCCCEEEEECCHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHH
PAAVTKRLAIEAGSSFGWAKYVGLSGKTLTIDTWGASAPGNRIFEEYGFTVANATELYKS
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHCCEEECHHHHHHC
L
C
>Mature Secondary Structure 
TFDAIDQLAVNTVRTLSMDAIQAANSGHPGLPMGAAPMAYVLWNHFMNINPKTSRNWSN
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
RDRFILSAGHGSAMLYSLLHLAGYDLSVEDLKNFRQWGSKTPGHPEVNHTDGVEATTGPL
CCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
GQGIANAVGMAMAEAHLAAKFNKPGFDIVDHYTFALNGDGDLMEGVSQEAASMAGHLKLG
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCEEEC
KLVLLYDSNDISLDGPTSMAFTEDVKGRFEAYGWQHILVKDGNDLEEIAAAIEAAKAETE
CEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCC
KPTIIEVKTIIGFGAEKQGTSAVHGAPLGAEGIAFAKKAYQWTHQDFEVPAEVTERFAQG
CCEEEEEEHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LQARGEKAEQAWNDLFAAYEAEYPELAAEYQKAFTNEAAQVELEAHELGSSMASRVSSQQ
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHEEEEHHHHHHHHHHHHHHHHH
AIQQISEQVASFWGGSADLSASNNTMVKAETDFQPGHYEGRNIWFGVREFAMAAAMNGIA
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHHCCEE
LHGGTRVYGGTFFVFSNYLLPAVRMAALQNLPTVYVMTHDSIAVGEDGPTHEPIEQLASV
EECCCEEECCEEHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHH
RSMPNLNVIRPADGNETNAAWKRAIAETDRPTMLVLTRQNLPVLEGTKELAEDGLSKGAY
HCCCCCCEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCHHCCCHHHHHCCCCCCEE
ILSEAKGDLDGILIATGSEVKLAMDTQEALEAEGIHVRVVSMPSQNIFDEQSAEYKESIL
EEECCCCCCCEEEEECCCCEEEEECCHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHH
PAAVTKRLAIEAGSSFGWAKYVGLSGKTLTIDTWGASAPGNRIFEEYGFTVANATELYKS
HHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHCCEEECHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA