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The map label for this gene is mutS2 [H]

Identifier: 160902544

GI number: 160902544

Start: 1156529

End: 1157872

Strand: Direct

Name: mutS2 [H]

Synonym: Pmob_1083

Alternate gene names: 160902544

Gene position: 1156529-1157872 (Clockwise)

Preceding gene: 160902543

Following gene: 160902545

Centisome position: 53.31

GC content: 30.21

Gene sequence:

>1344_bases
ATGGATGATTTAGAATATATACTTCAAAAGTTAGATGTTGTTACTCCCTTAGGAGTAAAAAAAATAAAAAATTTAGAATT
TTATACCAATACTATCCAAATAAAACAAGAACTGGATAAAATTGAGGAAGCTATATTAGCAATCAAAAGGGAAAAGAAAT
CACTAAGCAAAATCAAATCCAACCTCAAATACATAAAAGACATTAACTACATTATAGGAAGACTAAAAAACTGCGAGGTT
TTGGATGATATAGAACTATTTGAAATAAAATTTTTTTCTATATATTATGAAGAAATAAGGAAACTAGTCAATTTCTCTTT
TTTAAAACTACCTTCTTTGGAAAAAGTGATAGCCATTCTGGATCCAGAAGGGAACAAACTTCCAACATTTTACATTTACA
ATTCATACTCTCGTGAACTTGCATCGATCAGAAGAAAGAGAAAAAACGCTCCTCAAGAAGAAAAAGACTTATTATACCAA
AAAGAAATGGAAATAGAAGAAAAAATAAGATATAACCTTTCTGTAAAATTGACAGAATATTCGTCAGAATTGGAACAGGC
CTTAAAAGACCTAGAGGAATTAGATTTCATACTAGCTAAAGCAGAACTAGCAATGAACCTAAAGCTTTCAAAACCCGAAC
TTTCAAGCAATATAGAATATGAGGGATTATTCAATCCACTCATCAAAGAACAATTAGAAAAAACGAACCAAATATATCAA
CCGATAAACATAAAATTAGGTAAAGGAACAACGTTAATAACCGGGGCAAACATGACAGGAAAAACAGTAATACTAAGATC
TTTGGCATTATCCCAATATCTTTTTCAATATGGGTTCTACGTTCCCGCAAGGCATGCAAAAATCAAACCGGTTGATAAAA
TATTTTTGGTTTCAGGTGATTATCAATCGATCTTAAGTGGTTTATCTTCATACGCCGCCGAGATTTTAAAATTAAATGAA
ATATTAACGTACATTAAGCAAGATGATTCAGCATTGATATTACTTGATGAAATAGCAAGAAACACAAATCCTCATGAGGG
TAGATTAATTGTGAAAGCTGTCATTAAAATTCTCAACAATTACCATTCTATATCGGTAGTTACAACCCATTTCAACAACG
TTGCGGAAAAAAATATAAAAAAATTTAGAATTAAAGGAATTAAAAAATCTCTACTTAAAATGTATATTTCTCCAACAGAC
ATCACAGAATTAATGGATTACTCTTTAATAGAAGACAAGAAGGGAAAAGTCCCAGAAGAAGCATTAACAATTGCAAAAAT
GCTCAATATTGATAAAGAATTTATAAATACCATCGAAGAGTTGAAAAAGGAGGACCAATTGTGA

Upstream 100 bases:

>100_bases
CTATCTCTCCATACGGATATACTATGGACTCAGATGAAATCATAAAGAGATTAAAAGAAGCAATAAACATACCGATAATA
AACGTGAGGGAAAGTCAATC

Downstream 100 bases:

>100_bases
ACAAATTAAATTTGGATCAAAATAAAATTGAACATGCCAGAAACTTAGCTAAAAATATCGCCTTGGATGTTCAAAAATAT
GTTGAGGAAAGATCCACTGT

Product: DNA mismatch repair protein MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MDDLEYILQKLDVVTPLGVKKIKNLEFYTNTIQIKQELDKIEEAILAIKREKKSLSKIKSNLKYIKDINYIIGRLKNCEV
LDDIELFEIKFFSIYYEEIRKLVNFSFLKLPSLEKVIAILDPEGNKLPTFYIYNSYSRELASIRRKRKNAPQEEKDLLYQ
KEMEIEEKIRYNLSVKLTEYSSELEQALKDLEELDFILAKAELAMNLKLSKPELSSNIEYEGLFNPLIKEQLEKTNQIYQ
PINIKLGKGTTLITGANMTGKTVILRSLALSQYLFQYGFYVPARHAKIKPVDKIFLVSGDYQSILSGLSSYAAEILKLNE
ILTYIKQDDSALILLDEIARNTNPHEGRLIVKAVIKILNNYHSISVVTTHFNNVAEKNIKKFRIKGIKKSLLKMYISPTD
ITELMDYSLIEDKKGKVPEEALTIAKMLNIDKEFINTIEELKKEDQL

Sequences:

>Translated_447_residues
MDDLEYILQKLDVVTPLGVKKIKNLEFYTNTIQIKQELDKIEEAILAIKREKKSLSKIKSNLKYIKDINYIIGRLKNCEV
LDDIELFEIKFFSIYYEEIRKLVNFSFLKLPSLEKVIAILDPEGNKLPTFYIYNSYSRELASIRRKRKNAPQEEKDLLYQ
KEMEIEEKIRYNLSVKLTEYSSELEQALKDLEELDFILAKAELAMNLKLSKPELSSNIEYEGLFNPLIKEQLEKTNQIYQ
PINIKLGKGTTLITGANMTGKTVILRSLALSQYLFQYGFYVPARHAKIKPVDKIFLVSGDYQSILSGLSSYAAEILKLNE
ILTYIKQDDSALILLDEIARNTNPHEGRLIVKAVIKILNNYHSISVVTTHFNNVAEKNIKKFRIKGIKKSLLKMYISPTD
ITELMDYSLIEDKKGKVPEEALTIAKMLNIDKEFINTIEELKKEDQL
>Mature_447_residues
MDDLEYILQKLDVVTPLGVKKIKNLEFYTNTIQIKQELDKIEEAILAIKREKKSLSKIKSNLKYIKDINYIIGRLKNCEV
LDDIELFEIKFFSIYYEEIRKLVNFSFLKLPSLEKVIAILDPEGNKLPTFYIYNSYSRELASIRRKRKNAPQEEKDLLYQ
KEMEIEEKIRYNLSVKLTEYSSELEQALKDLEELDFILAKAELAMNLKLSKPELSSNIEYEGLFNPLIKEQLEKTNQIYQ
PINIKLGKGTTLITGANMTGKTVILRSLALSQYLFQYGFYVPARHAKIKPVDKIFLVSGDYQSILSGLSSYAAEILKLNE
ILTYIKQDDSALILLDEIARNTNPHEGRLIVKAVIKILNNYHSISVVTTHFNNVAEKNIKKFRIKGIKKSLLKMYISPTD
ITELMDYSLIEDKKGKVPEEALTIAKMLNIDKEFINTIEELKKEDQL

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=207, Percent_Identity=30.4347826086957, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI36949366, Length=388, Percent_Identity=24.4845360824742, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI26638666, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI4505253, Length=265, Percent_Identity=27.1698113207547, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI26638664, Length=266, Percent_Identity=27.4436090225564, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI4504191, Length=126, Percent_Identity=32.5396825396825, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI262231786, Length=266, Percent_Identity=27.4436090225564, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI1789089, Length=214, Percent_Identity=28.5046728971963, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508445, Length=232, Percent_Identity=30.6034482758621, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17534743, Length=190, Percent_Identity=26.8421052631579, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=126, Percent_Identity=30.1587301587302, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539736, Length=180, Percent_Identity=26.1111111111111, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=304, Percent_Identity=29.2763157894737, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=210, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321912, Length=202, Percent_Identity=30.6930693069307, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324482, Length=173, Percent_Identity=30.635838150289, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664545, Length=210, Percent_Identity=28.0952380952381, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24584320, Length=196, Percent_Identity=23.9795918367347, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 51760; Mature: 51760

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDLEYILQKLDVVTPLGVKKIKNLEFYTNTIQIKQELDKIEEAILAIKREKKSLSKIKS
CCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKYIKDINYIIGRLKNCEVLDDIELFEIKFFSIYYEEIRKLVNFSFLKLPSLEKVIAIL
HHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHEEEEE
DPEGNKLPTFYIYNSYSRELASIRRKRKNAPQEEKDLLYQKEMEIEEKIRYNLSVKLTEY
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCEEEEEEHH
SSELEQALKDLEELDFILAKAELAMNLKLSKPELSSNIEYEGLFNPLIKEQLEKTNQIYQ
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PINIKLGKGTTLITGANMTGKTVILRSLALSQYLFQYGFYVPARHAKIKPVDKIFLVSGD
CCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCC
YQSILSGLSSYAAEILKLNEILTYIKQDDSALILLDEIARNTNPHEGRLIVKAVIKILNN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHCC
YHSISVVTTHFNNVAEKNIKKFRIKGIKKSLLKMYISPTDITELMDYSLIEDKKGKVPEE
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHH
ALTIAKMLNIDKEFINTIEELKKEDQL
HHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDDLEYILQKLDVVTPLGVKKIKNLEFYTNTIQIKQELDKIEEAILAIKREKKSLSKIKS
CCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLKYIKDINYIIGRLKNCEVLDDIELFEIKFFSIYYEEIRKLVNFSFLKLPSLEKVIAIL
HHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHEEEEE
DPEGNKLPTFYIYNSYSRELASIRRKRKNAPQEEKDLLYQKEMEIEEKIRYNLSVKLTEY
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCEEEEEEHH
SSELEQALKDLEELDFILAKAELAMNLKLSKPELSSNIEYEGLFNPLIKEQLEKTNQIYQ
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
PINIKLGKGTTLITGANMTGKTVILRSLALSQYLFQYGFYVPARHAKIKPVDKIFLVSGD
CCEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCC
YQSILSGLSSYAAEILKLNEILTYIKQDDSALILLDEIARNTNPHEGRLIVKAVIKILNN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCHHHHHHHHHHHCC
YHSISVVTTHFNNVAEKNIKKFRIKGIKKSLLKMYISPTDITELMDYSLIEDKKGKVPEE
CCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCHH
ALTIAKMLNIDKEFINTIEELKKEDQL
HHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA