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The map label for this gene is rfbB [H]

Identifier: 160902404

GI number: 160902404

Start: 993248

End: 994294

Strand: Direct

Name: rfbB [H]

Synonym: Pmob_0939

Alternate gene names: 160902404

Gene position: 993248-994294 (Clockwise)

Preceding gene: 160902403

Following gene: 160902405

Centisome position: 45.78

GC content: 36.01

Gene sequence:

>1047_bases
TTGAGTATCTTAGTAACAGGGGTAGCTGGATTCATAGGAAGTAACTTCGTATACTACTACTTAAGAAAACACAAAGACAA
AAAGATAATAGGTTTAGACAAACTAACCTATGCAGGGAATTTGGATAACCTATCCAAATTAAATGAAGAAGAAAAAAATA
GGTTCACCTTCATAAAAGGTGACATAAACGATATAGAACTGTTGGAAAAGATATACAAAGAAAACGAAATAGAAGGGATA
ATAAACTTCGCTGCCGAAAGTCATGTTGACAGATCAATACACGATCCTCAGATATTTTTAAAAACAAACATACTGGGAAC
ACAAACGTTGTTGCATGTATTCAAAAAATACTACGATGAAAGAAAAAGACAGAAATTCTTACAAATATCAACCGATGAAG
TGTATGGAGCGTTGGGACCAACGGGATACTTCACAGAAAAAACACCCCTTGATCCACACAGTCCATACTCTGCAAGTAAA
GCGAGTGCAGATTTGATAGTAAAGGCTTACCACGATACATATGGACTAAATACGAACATAACAAGATGCTCAAACAACTA
TGGACCATACCAATTCCCAGAAAAGCTCATACCGCTGATGATAAACAACGCGTTAAACCACAAAGAGTTACCTGTGTATG
GAGATGGCAAACAGATAAGGGACTGGTTGTACGTGGAAGATCATTGCAAAGCGATAGAGCTTGTATTTGAAAAAGGAAGA
AGTGGAGAAGTATACAACATAGGTGGACACAACGAGAAAGAAAACATAGAAATAGTAAAAATAATAATAGAATACTTACA
AGAAAAAACAAAAGGCGAAAAGATAAACGAAGGTTTGATTAAACATGTGAAAGACAGGTTAGGACATGACAGAAGATACG
CGATAGACCCAACGAAGATAAAAGAAGAGTTAGGTTGGGAACCAGAGACAAAGTTTGAAGAAGGGATAAAAAGAACGATA
GATTGGTACCTTGAAAACAAAGAATGGATGGAGAAGGTTATAACAGGGGAGTATTTGGAGTTTTATAGGAGGAATTATGG
TAGTTAG

Upstream 100 bases:

>100_bases
GGAACAAATGGATAACAAAAGAAGAATTGATTAAATTGGGTAAAGAATATGAAAAGACTGAATATGGTCAATACATTCTT
AGATTTGCGAGTGATATAAA

Downstream 100 bases:

>100_bases
ATTGCGATAATGGATCTAAAAAAGAATTTACTAAAAGTTTTTACTGCAAATTTTATAGCTTTAGCTGTAAGTTTTGTGAA
TAGTTTCTTTCTTACCTCTT

Product: dTDP-glucose 4,6-dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MSILVTGVAGFIGSNFVYYYLRKHKDKKIIGLDKLTYAGNLDNLSKLNEEEKNRFTFIKGDINDIELLEKIYKENEIEGI
INFAAESHVDRSIHDPQIFLKTNILGTQTLLHVFKKYYDERKRQKFLQISTDEVYGALGPTGYFTEKTPLDPHSPYSASK
ASADLIVKAYHDTYGLNTNITRCSNNYGPYQFPEKLIPLMINNALNHKELPVYGDGKQIRDWLYVEDHCKAIELVFEKGR
SGEVYNIGGHNEKENIEIVKIIIEYLQEKTKGEKINEGLIKHVKDRLGHDRRYAIDPTKIKEELGWEPETKFEEGIKRTI
DWYLENKEWMEKVITGEYLEFYRRNYGS

Sequences:

>Translated_348_residues
MSILVTGVAGFIGSNFVYYYLRKHKDKKIIGLDKLTYAGNLDNLSKLNEEEKNRFTFIKGDINDIELLEKIYKENEIEGI
INFAAESHVDRSIHDPQIFLKTNILGTQTLLHVFKKYYDERKRQKFLQISTDEVYGALGPTGYFTEKTPLDPHSPYSASK
ASADLIVKAYHDTYGLNTNITRCSNNYGPYQFPEKLIPLMINNALNHKELPVYGDGKQIRDWLYVEDHCKAIELVFEKGR
SGEVYNIGGHNEKENIEIVKIIIEYLQEKTKGEKINEGLIKHVKDRLGHDRRYAIDPTKIKEELGWEPETKFEEGIKRTI
DWYLENKEWMEKVITGEYLEFYRRNYGS
>Mature_347_residues
SILVTGVAGFIGSNFVYYYLRKHKDKKIIGLDKLTYAGNLDNLSKLNEEEKNRFTFIKGDINDIELLEKIYKENEIEGII
NFAAESHVDRSIHDPQIFLKTNILGTQTLLHVFKKYYDERKRQKFLQISTDEVYGALGPTGYFTEKTPLDPHSPYSASKA
SADLIVKAYHDTYGLNTNITRCSNNYGPYQFPEKLIPLMINNALNHKELPVYGDGKQIRDWLYVEDHCKAIELVFEKGRS
GEVYNIGGHNEKENIEIVKIIIEYLQEKTKGEKINEGLIKHVKDRLGHDRRYAIDPTKIKEELGWEPETKFEEGIKRTID
WYLENKEWMEKVITGEYLEFYRRNYGS

Specific function: Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction [H]

COG id: COG1088

COG function: function code M; dTDP-D-glucose 4,6-dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. dTDP-glucose dehydratase subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=324, Percent_Identity=38.2716049382716, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI42516563, Length=336, Percent_Identity=26.4880952380952, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4504031, Length=335, Percent_Identity=26.2686567164179, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI56237023, Length=358, Percent_Identity=25.6983240223464, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI56118217, Length=358, Percent_Identity=25.6983240223464, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI189083684, Length=358, Percent_Identity=25.6983240223464, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI48994969, Length=346, Percent_Identity=52.8901734104046, Blast_Score=355, Evalue=2e-99,
Organism=Escherichia coli, GI1788353, Length=360, Percent_Identity=49.1666666666667, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1788366, Length=347, Percent_Identity=24.207492795389, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786974, Length=346, Percent_Identity=26.0115606936416, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17568069, Length=327, Percent_Identity=38.2262996941896, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI115532424, Length=323, Percent_Identity=32.5077399380805, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71982035, Length=362, Percent_Identity=27.3480662983425, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71982038, Length=364, Percent_Identity=27.1978021978022, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17539532, Length=329, Percent_Identity=26.4437689969605, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17507723, Length=339, Percent_Identity=23.598820058997, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI133901786, Length=339, Percent_Identity=24.188790560472, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17539422, Length=341, Percent_Identity=24.0469208211144, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI133901790, Length=341, Percent_Identity=24.0469208211144, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI133901788, Length=341, Percent_Identity=24.0469208211144, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17539424, Length=236, Percent_Identity=25.8474576271186, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=355, Percent_Identity=27.3239436619718, Blast_Score=93, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21356223, Length=327, Percent_Identity=27.5229357798165, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19923002, Length=358, Percent_Identity=26.8156424581006, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24158427, Length=337, Percent_Identity=25.2225519287834, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005888
- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =4.2.1.46 [H]

Molecular weight: Translated: 40568; Mature: 40436

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVTGVAGFIGSNFVYYYLRKHKDKKIIGLDKLTYAGNLDNLSKLNEEEKNRFTFIKG
CCEEEEEHHHHHHCCHHEEEEHHCCCCCEECCHHHEECCCCHHHHHCCHHHCCCEEEEEC
DINDIELLEKIYKENEIEGIINFAAESHVDRSIHDPQIFLKTNILGTQTLLHVFKKYYDE
CCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
RKRQKFLQISTDEVYGALGPTGYFTEKTPLDPHSPYSASKASADLIVKAYHDTYGLNTNI
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCE
TRCSNNYGPYQFPEKLIPLMINNALNHKELPVYGDGKQIRDWLYVEDHCKAIELVFEKGR
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCC
SGEVYNIGGHNEKENIEIVKIIIEYLQEKTKGEKINEGLIKHVKDRLGHDRRYAIDPTKI
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCHHHH
KEELGWEPETKFEEGIKRTIDWYLENKEWMEKVITGEYLEFYRRNYGS
HHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SILVTGVAGFIGSNFVYYYLRKHKDKKIIGLDKLTYAGNLDNLSKLNEEEKNRFTFIKG
CEEEEEHHHHHHCCHHEEEEHHCCCCCEECCHHHEECCCCHHHHHCCHHHCCCEEEEEC
DINDIELLEKIYKENEIEGIINFAAESHVDRSIHDPQIFLKTNILGTQTLLHVFKKYYDE
CCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
RKRQKFLQISTDEVYGALGPTGYFTEKTPLDPHSPYSASKASADLIVKAYHDTYGLNTNI
HHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCCCCCE
TRCSNNYGPYQFPEKLIPLMINNALNHKELPVYGDGKQIRDWLYVEDHCKAIELVFEKGR
EECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCC
SGEVYNIGGHNEKENIEIVKIIIEYLQEKTKGEKINEGLIKHVKDRLGHDRRYAIDPTKI
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCHHHH
KEELGWEPETKFEEGIKRTIDWYLENKEWMEKVITGEYLEFYRRNYGS
HHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8253667 [H]