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The map label for this gene is mtnA2

Identifier: 160902276

GI number: 160902276

Start: 849427

End: 850476

Strand: Direct

Name: mtnA2

Synonym: Pmob_0810

Alternate gene names: 160902276

Gene position: 849427-850476 (Clockwise)

Preceding gene: 160902275

Following gene: 160902277

Centisome position: 39.15

GC content: 36.76

Gene sequence:

>1050_bases
ATGAAAAACATAAAAACTATGACAATGGAATGGACAGGTAACAGTCTAATTTTGATAGATCAGAGGTATTTACCTATTGA
AGAAAAGTATGTAGAATGTCAGAATTATTTGGATGTTGCCAATTCAATAAAAGACATGGTAGTAAGAGGAGCTCCTGCTA
TAGGAGCAACCGCAGCATTTGGCTTTGTTTTAGGGGCAAAAGAGTTTTCCTATCTTTCTGACAAGAATCTTTTTTCAAAC
AAATTAGAAGAAGTAAAAAACAGTTTATCTAAAACTCGCCCCACTGCCGTAAACTTATTTTGGGCGTTGAACAGGATGGA
TAAAATTTTAAAAGATAATCTTCCCACAAAAGAAATAAATGACCTTGTCACCATATTAGAAGAAGAAGCACTGAAAATCG
CCTACGAAGATATTGAAATAAATAAACAGATCGGCAAGAACGGAGAAGCTTTGTTAAACGACGGTGACACCGTTTTGACG
CATTGCAATGCAGGAGCATTAGCAACTGTTGATTATGGAACCGCTTTAGGGGTTATTAGAGCGGCAGTAGAAAATGGTAA
AGATATCCAGGTCTATGCAGATGAAACCAGACCATACCTTCAAGGGGCTAGATTAACGGTTTGGGAATTGGTTAAAAGTG
GTATCAAAACTACACTAATTACAGACAACATGGCAGGTTGGGTAATGAAACAAGGAAAAATAAATGCTGTGATAGTAGGA
GCCGATAGAATCGCACGTAATGGGGATGTTGCTAATAAAATTGGAACGTATTCTGTAGCCGTTCTTGCAAAAAGGCACGG
CATTCCTTTTTATGTTGCTGCTCCACTTTCTACTATAGACATAGAAACAAAAAATGGGGAAGGTATTCCCATCGAAGAAA
GGAACCATAATGAGGTCAGATTTTGCCACAAAACTCGTTTAGTAACAGACGATGTAAATATATACAACCCTGCTTTTGAT
GTAACTCCAAATGAATTAGTTACAGCGATAATTACCGAAAAGATGGTCATAAGACCACCTTATGAAATAAACATAGTGAA
ATTATTTTAG

Upstream 100 bases:

>100_bases
AGGTCCCTTCTTTGAATAAGCGAAAACGGGGTCTAAGATACGCTAGCACTTGTTTTAGAATCGTTAAAATCATTAAAATC
TTAGGTCGAGGAGGAAGCAA

Downstream 100 bases:

>100_bases
CTTGCCCTTTTGCAGCTTTGTGCAAAAAGATTTTTGCTGCTTCGTGCAAAACGTCTTTTTGCAATTGTTTTAGAATAATT
TCCATACCCTCATTTGCTTC

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi 2; MTR-1-P isomerase 2; S-methyl-5-thioribose-1-phosphate isomerase 2

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKNIKTMTMEWTGNSLILIDQRYLPIEEKYVECQNYLDVANSIKDMVVRGAPAIGATAAFGFVLGAKEFSYLSDKNLFSN
KLEEVKNSLSKTRPTAVNLFWALNRMDKILKDNLPTKEINDLVTILEEEALKIAYEDIEINKQIGKNGEALLNDGDTVLT
HCNAGALATVDYGTALGVIRAAVENGKDIQVYADETRPYLQGARLTVWELVKSGIKTTLITDNMAGWVMKQGKINAVIVG
ADRIARNGDVANKIGTYSVAVLAKRHGIPFYVAAPLSTIDIETKNGEGIPIEERNHNEVRFCHKTRLVTDDVNIYNPAFD
VTPNELVTAIITEKMVIRPPYEINIVKLF

Sequences:

>Translated_349_residues
MKNIKTMTMEWTGNSLILIDQRYLPIEEKYVECQNYLDVANSIKDMVVRGAPAIGATAAFGFVLGAKEFSYLSDKNLFSN
KLEEVKNSLSKTRPTAVNLFWALNRMDKILKDNLPTKEINDLVTILEEEALKIAYEDIEINKQIGKNGEALLNDGDTVLT
HCNAGALATVDYGTALGVIRAAVENGKDIQVYADETRPYLQGARLTVWELVKSGIKTTLITDNMAGWVMKQGKINAVIVG
ADRIARNGDVANKIGTYSVAVLAKRHGIPFYVAAPLSTIDIETKNGEGIPIEERNHNEVRFCHKTRLVTDDVNIYNPAFD
VTPNELVTAIITEKMVIRPPYEINIVKLF
>Mature_349_residues
MKNIKTMTMEWTGNSLILIDQRYLPIEEKYVECQNYLDVANSIKDMVVRGAPAIGATAAFGFVLGAKEFSYLSDKNLFSN
KLEEVKNSLSKTRPTAVNLFWALNRMDKILKDNLPTKEINDLVTILEEEALKIAYEDIEINKQIGKNGEALLNDGDTVLT
HCNAGALATVDYGTALGVIRAAVENGKDIQVYADETRPYLQGARLTVWELVKSGIKTTLITDNMAGWVMKQGKINAVIVG
ADRIARNGDVANKIGTYSVAVLAKRHGIPFYVAAPLSTIDIETKNGEGIPIEERNHNEVRFCHKTRLVTDDVNIYNPAFD
VTPNELVTAIITEKMVIRPPYEINIVKLF

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=352, Percent_Identity=40.3409090909091, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI23943880, Length=341, Percent_Identity=35.1906158357771, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI4503503, Length=198, Percent_Identity=29.2929292929293, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI78000158, Length=274, Percent_Identity=23.3576642335766, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI187607323, Length=274, Percent_Identity=23.3576642335766, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI78000156, Length=274, Percent_Identity=23.3576642335766, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI7657058, Length=157, Percent_Identity=29.2993630573248, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=334, Percent_Identity=39.2215568862275, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17557123, Length=275, Percent_Identity=26.9090909090909, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=384, Percent_Identity=36.9791666666667, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6322878, Length=206, Percent_Identity=31.0679611650485, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357667, Length=351, Percent_Identity=41.5954415954416, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651647, Length=351, Percent_Identity=41.5954415954416, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI21358605, Length=191, Percent_Identity=28.2722513089005, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281364091, Length=267, Percent_Identity=26.5917602996255, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24659399, Length=267, Percent_Identity=26.5917602996255, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24659407, Length=267, Percent_Identity=26.5917602996255, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI19922816, Length=267, Percent_Identity=26.5917602996255, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA2_PETMO (A9BHC5)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001567857.1
- ProteinModelPortal:   A9BHC5
- SMR:   A9BHC5
- GeneID:   5756628
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_0810
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- ProtClustDB:   CLSK875467
- BioCyc:   PMOB403833:PMOB_0810-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 38765; Mature: 38765

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: ACT_SITE 242-242 BINDING 93-93 BINDING 201-201

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIKTMTMEWTGNSLILIDQRYLPIEEKYVECQNYLDVANSIKDMVVRGAPAIGATAAF
CCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GFVLGAKEFSYLSDKNLFSNKLEEVKNSLSKTRPTAVNLFWALNRMDKILKDNLPTKEIN
HHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
DLVTILEEEALKIAYEDIEINKQIGKNGEALLNDGDTVLTHCNAGALATVDYGTALGVIR
HHHHHHHHHHHHEEEHHEEECHHHCCCCCEEECCCCEEEEECCCCEEEEECCHHHHHHHH
AAVENGKDIQVYADETRPYLQGARLTVWELVKSGIKTTLITDNMAGWVMKQGKINAVIVG
HHHHCCCEEEEEECCCCCHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEE
ADRIARNGDVANKIGTYSVAVLAKRHGIPFYVAAPLSTIDIETKNGEGIPIEERNHNEVR
CHHHCCCCCCHHHCCCCEEEEEHHHCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEE
FCHKTRLVTDDVNIYNPAFDVTPNELVTAIITEKMVIRPPYEINIVKLF
EEEEEEEEECCCEEECCCCCCCHHHHHHHHHHCCEEECCCCEEEEEEEC
>Mature Secondary Structure
MKNIKTMTMEWTGNSLILIDQRYLPIEEKYVECQNYLDVANSIKDMVVRGAPAIGATAAF
CCCCEEEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GFVLGAKEFSYLSDKNLFSNKLEEVKNSLSKTRPTAVNLFWALNRMDKILKDNLPTKEIN
HHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHH
DLVTILEEEALKIAYEDIEINKQIGKNGEALLNDGDTVLTHCNAGALATVDYGTALGVIR
HHHHHHHHHHHHEEEHHEEECHHHCCCCCEEECCCCEEEEECCCCEEEEECCHHHHHHHH
AAVENGKDIQVYADETRPYLQGARLTVWELVKSGIKTTLITDNMAGWVMKQGKINAVIVG
HHHHCCCEEEEEECCCCCHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEECCCCCEEEEE
ADRIARNGDVANKIGTYSVAVLAKRHGIPFYVAAPLSTIDIETKNGEGIPIEERNHNEVR
CHHHCCCCCCHHHCCCCEEEEEHHHCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCEE
FCHKTRLVTDDVNIYNPAFDVTPNELVTAIITEKMVIRPPYEINIVKLF
EEEEEEEEECCCEEECCCCCCCHHHHHHHHHHCCEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA