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The map label for this gene is era [H]

Identifier: 160901780

GI number: 160901780

Start: 318839

End: 319759

Strand: Direct

Name: era [H]

Synonym: Pmob_0296

Alternate gene names: 160901780

Gene position: 318839-319759 (Clockwise)

Preceding gene: 160901759

Following gene: 160901783

Centisome position: 14.7

GC content: 32.03

Gene sequence:

>921_bases
ATGGAAAACGACAGTTTTAAAAGTGGCTTTGTTGCCTTGGCAGGAAAACCTAACGTTGGAAAATCAACATTGATAAACGC
TTTGTTGGGTCAAAAAGTGGTTATCGTTTCTGACAAGACACAAACCACAAGAAATAGAGTAAACTGTATATTAACGGAAG
ATCATTATCAAATAGTCTTTGTCGACACCCCAGGTATTCACAAACCTATAAGAAAAATTGGGGAATACATGGTCAATATT
GCAATAAATGCATTGAAAGGCGTTGACCTGATACTTTTTATAATCGATGCAAAGGATGGTTTAAGAAATTCAGATTTAAG
AGTTACTGAAATAGTTGATAAATCAAAAATTCCTACCATTCTTCTTGTCAACAAAGTTGACCTAGTAAAAGACAAAGAAA
AGATTAACCTGATGACGGAAAAAATACAAAGTTTGTGTTCAAATATAGTTAAAACCATTGAAATTTCCGCTTTGACGGGT
AAAAATCTTTCTGAATTAAAACAAAGTATTATAGATTTATTACCCGAAGGTCCACAATACTACCCAGAAGATATGATCAC
TGATAAACCTTCAAGGTTCATCATTTCTGAATTAATTCGGGAAAAAATCTTTCATTTAACAAAGGAAGAGATCCCTCATT
CAAGCGGTGTAGTTGTAGAAGAATTGAAAGAAAGAGAAAACGGCGTTTTGTACGTAAGAGCAGAAATTTATGTTGAAAAG
AAAAGTCAAAAACCTATTATAATAGGTAAAAACGGAAGTATGATTAAAAAGATCGGTCAATTAGCAAGACAAGACATAGA
AGAACTTTTTGAAAGAAAAGTCTACCTCGATCTTTACGTAAAGGTTCGTGAAAAATGGAGAGACGACAAAAATATTTTAA
ATAACATTATGGAATACAAAATAGAAGAAATAAAAGATTGA

Upstream 100 bases:

>100_bases
GTTTGACAAATTGCCGTTTATAACTTGACTTTTGCATCAGACTACAATACAATATCAATAATGAGTGTGATTTTTCAAAT
ATAGTTTTTTGGAGGAAAAC

Downstream 100 bases:

>100_bases
AAATAGACTGCTATATGCAACTTAATCAATTCTAAAAGCCTTGTCAGCTTCTATAATCTCCTGCGCTACATCAACTAACT
TTTTGTTGGAATTTCTACTC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MENDSFKSGFVALAGKPNVGKSTLINALLGQKVVIVSDKTQTTRNRVNCILTEDHYQIVFVDTPGIHKPIRKIGEYMVNI
AINALKGVDLILFIIDAKDGLRNSDLRVTEIVDKSKIPTILLVNKVDLVKDKEKINLMTEKIQSLCSNIVKTIEISALTG
KNLSELKQSIIDLLPEGPQYYPEDMITDKPSRFIISELIREKIFHLTKEEIPHSSGVVVEELKERENGVLYVRAEIYVEK
KSQKPIIIGKNGSMIKKIGQLARQDIEELFERKVYLDLYVKVREKWRDDKNILNNIMEYKIEEIKD

Sequences:

>Translated_306_residues
MENDSFKSGFVALAGKPNVGKSTLINALLGQKVVIVSDKTQTTRNRVNCILTEDHYQIVFVDTPGIHKPIRKIGEYMVNI
AINALKGVDLILFIIDAKDGLRNSDLRVTEIVDKSKIPTILLVNKVDLVKDKEKINLMTEKIQSLCSNIVKTIEISALTG
KNLSELKQSIIDLLPEGPQYYPEDMITDKPSRFIISELIREKIFHLTKEEIPHSSGVVVEELKERENGVLYVRAEIYVEK
KSQKPIIIGKNGSMIKKIGQLARQDIEELFERKVYLDLYVKVREKWRDDKNILNNIMEYKIEEIKD
>Mature_306_residues
MENDSFKSGFVALAGKPNVGKSTLINALLGQKVVIVSDKTQTTRNRVNCILTEDHYQIVFVDTPGIHKPIRKIGEYMVNI
AINALKGVDLILFIIDAKDGLRNSDLRVTEIVDKSKIPTILLVNKVDLVKDKEKINLMTEKIQSLCSNIVKTIEISALTG
KNLSELKQSIIDLLPEGPQYYPEDMITDKPSRFIISELIREKIFHLTKEEIPHSSGVVVEELKERENGVLYVRAEIYVEK
KSQKPIIIGKNGSMIKKIGQLARQDIEELFERKVYLDLYVKVREKWRDDKNILNNIMEYKIEEIKD

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=26.7080745341615, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1788919, Length=299, Percent_Identity=40.8026755852843, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082120, Length=165, Percent_Identity=29.0909090909091, Blast_Score=74, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323665, Length=184, Percent_Identity=34.2391304347826, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24646434, Length=307, Percent_Identity=26.3843648208469, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34962; Mature: 34962

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENDSFKSGFVALAGKPNVGKSTLINALLGQKVVIVSDKTQTTRNRVNCILTEDHYQIVF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCHHHHCCEEEEEECCCEEEEE
VDTPGIHKPIRKIGEYMVNIAINALKGVDLILFIIDAKDGLRNSDLRVTEIVDKSKIPTI
EECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHCCCCCEE
LLVNKVDLVKDKEKINLMTEKIQSLCSNIVKTIEISALTGKNLSELKQSIIDLLPEGPQY
EEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCC
YPEDMITDKPSRFIISELIREKIFHLTKEEIPHSSGVVVEELKERENGVLYVRAEIYVEK
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEEEEE
KSQKPIIIGKNGSMIKKIGQLARQDIEELFERKVYLDLYVKVREKWRDDKNILNNIMEYK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEEIKD
HHHHCC
>Mature Secondary Structure
MENDSFKSGFVALAGKPNVGKSTLINALLGQKVVIVSDKTQTTRNRVNCILTEDHYQIVF
CCCCCCCCCEEEEECCCCCCHHHHHHHHHCCEEEEEECCCHHHHCCEEEEEECCCEEEEE
VDTPGIHKPIRKIGEYMVNIAINALKGVDLILFIIDAKDGLRNSDLRVTEIVDKSKIPTI
EECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHCCCCCEE
LLVNKVDLVKDKEKINLMTEKIQSLCSNIVKTIEISALTGKNLSELKQSIIDLLPEGPQY
EEEECHHHHCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHCCCCCCC
YPEDMITDKPSRFIISELIREKIFHLTKEEIPHSSGVVVEELKERENGVLYVRAEIYVEK
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEEEEEEE
KSQKPIIIGKNGSMIKKIGQLARQDIEELFERKVYLDLYVKVREKWRDDKNILNNIMEYK
CCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
IEEIKD
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]