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The map label for this gene is serS

Identifier: 160901593

GI number: 160901593

Start: 98663

End: 99937

Strand: Direct

Name: serS

Synonym: Pmob_0102

Alternate gene names: 160901593

Gene position: 98663-99937 (Clockwise)

Preceding gene: 160901592

Following gene: 160901594

Centisome position: 4.55

GC content: 34.35

Gene sequence:

>1275_bases
ATGTTAGACTTAAAGTATATCAGAGAAAATCCACAAGAAATAAAAGAAGCTTTAACAAAAAGAAACAACGAAACTTCTAT
AATAGATGAAATTATCTCTTTCGATGAAGAGAGAAGAAAATTGTTGCAACAAATCGAAACTCTTAGAGCCCAAAGAAATC
AAAATTCAAAATTAGTTGCTAAATTAAAAGCCCAAAAGAAAAATGATGAGGCCGAAGAAATAATTATCCAGGGAAAGGAA
ATCTCTGAACAAATAAAAAATCTGGAATCAGATTTGAAAAATATTGAAGACAATTTAAATTATAAATTATTATGTGTGCC
TAACATTCCTGACAGCGGTGTACCCGTTGGAAAGGATGAGAACGAAAATCTCGAAGTAAGAAGATGGGGAAAACCACGAG
AATTTGATTTTGAACCAAAAGCTCATTGGGATTTAGGCACAGAATTAAACCTCTTAGATTTTGACAGAGCAGCTAAACTA
AGCGGATCTCGATTCACCATCTTAAAAGGTGACATAGCCCGTTTAGAGTTGGCTTTAATCAACTTTATGATCGATTTACA
TACAAAAGATCACGGTTACACCTTTATACTGCCTCCACATCTAGTTACAAAAGAAACTATAACCTCTTCAGGTCAACTGC
CGAAATTCGAAGACGATTTATATAAAACTTCTTTGGATCAAATGTACCTTATTTCTACCGCCGAAGTTTCTCTGGCTGGT
TTACATAGAAACGAAACCTTAGAATTTAATTCACTCCCCTTAAAATACGTTGCTTATACACCTTGTTACAGAAGAGAAGC
AGGTAGTTATGGAAAAGATGTAAGAGGAATGATCAGACAACACCAATTCGATAAAGTAGAATTATTTTGGTATACAACTC
CTGAAGAATCCTCTCAAGCGTTGGAAGAATTAACAAGTCACGCAGAAAAGGTGCTGCAACTTTTGAATTTACCTTATAGA
GTTGTTGCTCTCTGTACCGGAGATTTAGGTTTTGCAGCAGCCAAGACTTATGATTTGGAAGTATGGTTACCTAGCTACAA
TGATTATAAAGAAATATCGTCATGTTCTAATACAAAAGATTTTCAAGGAAGAAGAGGAAACATAAGGTACAGGGATAGAG
AAAATAAGTTAAATTTTGTTCACACACTAAATGGTTCAGGATTAGCAGTTGGAAGAACTTTAGTAGCTATAATGGAAAAT
TATCAAACGGCTAATGGCAAGATAGAAATTCCTGAAAAACTCATTCCTTACATGGGAAAAGAGTTCATAGGTTGA

Upstream 100 bases:

>100_bases
AAATACAAGTCAAAAATTCAGCTTTATTAGATAGTTTAAGTAAATAGTCTAATTATAACTTTCATAATACTTTTAAAAAC
ATTCACTTCGGGAGGGTAAA

Downstream 100 bases:

>100_bases
TTATAGATGCCAAATACGTTTTACGGGAAAAAAGTAAATGAAGAAATTATTCTAAACGAAGAAGAAACTGCACACTTAAA
AATAACAAAAAAAGTCGAGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLDLKYIRENPQEIKEALTKRNNETSIIDEIISFDEERRKLLQQIETLRAQRNQNSKLVAKLKAQKKNDEAEEIIIQGKE
ISEQIKNLESDLKNIEDNLNYKLLCVPNIPDSGVPVGKDENENLEVRRWGKPREFDFEPKAHWDLGTELNLLDFDRAAKL
SGSRFTILKGDIARLELALINFMIDLHTKDHGYTFILPPHLVTKETITSSGQLPKFEDDLYKTSLDQMYLISTAEVSLAG
LHRNETLEFNSLPLKYVAYTPCYRREAGSYGKDVRGMIRQHQFDKVELFWYTTPEESSQALEELTSHAEKVLQLLNLPYR
VVALCTGDLGFAAAKTYDLEVWLPSYNDYKEISSCSNTKDFQGRRGNIRYRDRENKLNFVHTLNGSGLAVGRTLVAIMEN
YQTANGKIEIPEKLIPYMGKEFIG

Sequences:

>Translated_424_residues
MLDLKYIRENPQEIKEALTKRNNETSIIDEIISFDEERRKLLQQIETLRAQRNQNSKLVAKLKAQKKNDEAEEIIIQGKE
ISEQIKNLESDLKNIEDNLNYKLLCVPNIPDSGVPVGKDENENLEVRRWGKPREFDFEPKAHWDLGTELNLLDFDRAAKL
SGSRFTILKGDIARLELALINFMIDLHTKDHGYTFILPPHLVTKETITSSGQLPKFEDDLYKTSLDQMYLISTAEVSLAG
LHRNETLEFNSLPLKYVAYTPCYRREAGSYGKDVRGMIRQHQFDKVELFWYTTPEESSQALEELTSHAEKVLQLLNLPYR
VVALCTGDLGFAAAKTYDLEVWLPSYNDYKEISSCSNTKDFQGRRGNIRYRDRENKLNFVHTLNGSGLAVGRTLVAIMEN
YQTANGKIEIPEKLIPYMGKEFIG
>Mature_424_residues
MLDLKYIRENPQEIKEALTKRNNETSIIDEIISFDEERRKLLQQIETLRAQRNQNSKLVAKLKAQKKNDEAEEIIIQGKE
ISEQIKNLESDLKNIEDNLNYKLLCVPNIPDSGVPVGKDENENLEVRRWGKPREFDFEPKAHWDLGTELNLLDFDRAAKL
SGSRFTILKGDIARLELALINFMIDLHTKDHGYTFILPPHLVTKETITSSGQLPKFEDDLYKTSLDQMYLISTAEVSLAG
LHRNETLEFNSLPLKYVAYTPCYRREAGSYGKDVRGMIRQHQFDKVELFWYTTPEESSQALEELTSHAEKVLQLLNLPYR
VVALCTGDLGFAAAKTYDLEVWLPSYNDYKEISSCSNTKDFQGRRGNIRYRDRENKLNFVHTLNGSGLAVGRTLVAIMEN
YQTANGKIEIPEKLIPYMGKEFIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=464, Percent_Identity=33.1896551724138, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI8923421, Length=436, Percent_Identity=31.651376146789, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI225579074, Length=438, Percent_Identity=31.0502283105023, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787120, Length=434, Percent_Identity=51.1520737327189, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=472, Percent_Identity=32.6271186440678, Blast_Score=231, Evalue=5e-61,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=30.9090909090909, Blast_Score=158, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=455, Percent_Identity=35.6043956043956, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6321799, Length=424, Percent_Identity=35.1415094339623, Blast_Score=226, Evalue=8e-60,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=32.5581395348837, Blast_Score=224, Evalue=9e-59,
Organism=Drosophila melanogaster, GI17737985, Length=277, Percent_Identity=37.1841155234657, Blast_Score=163, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_PETMO (A9BEX3)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001567174.1
- ProteinModelPortal:   A9BEX3
- SMR:   A9BEX3
- GeneID:   5757827
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_0102
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- BioCyc:   PMOB403833:PMOB_0102-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48775; Mature: 48775

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKYIRENPQEIKEALTKRNNETSIIDEIISFDEERRKLLQQIETLRAQRNQNSKLVA
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHH
KLKAQKKNDEAEEIIIQGKEISEQIKNLESDLKNIEDNLNYKLLCVPNIPDSGVPVGKDE
HHHHHCCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
NENLEVRRWGKPREFDFEPKAHWDLGTELNLLDFDRAAKLSGSRFTILKGDIARLELALI
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCHHHHHHHHH
NFMIDLHTKDHGYTFILPPHLVTKETITSSGQLPKFEDDLYKTSLDQMYLISTAEVSLAG
HHHHEEEECCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEE
LHRNETLEFNSLPLKYVAYTPCYRREAGSYGKDVRGMIRQHQFDKVELFWYTTPEESSQA
CCCCCCEEECCCCEEEEEECCHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHH
LEELTSHAEKVLQLLNLPYRVVALCTGDLGFAAAKTYDLEVWLPSYNDYKEISSCSNTKD
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEEEEECCCCCHHHHHHCCCCCC
FQGRRGNIRYRDRENKLNFVHTLNGSGLAVGRTLVAIMENYQTANGKIEIPEKLIPYMGK
CCCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
EFIG
HHCC
>Mature Secondary Structure
MLDLKYIRENPQEIKEALTKRNNETSIIDEIISFDEERRKLLQQIETLRAQRNQNSKLVA
CCCHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHH
KLKAQKKNDEAEEIIIQGKEISEQIKNLESDLKNIEDNLNYKLLCVPNIPDSGVPVGKDE
HHHHHCCCCCHHHHEEECHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCC
NENLEVRRWGKPREFDFEPKAHWDLGTELNLLDFDRAAKLSGSRFTILKGDIARLELALI
CCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEECCHHHHCCCCEEEEEECCHHHHHHHHH
NFMIDLHTKDHGYTFILPPHLVTKETITSSGQLPKFEDDLYKTSLDQMYLISTAEVSLAG
HHHHEEEECCCCEEEEECCCHHHHHHHCCCCCCCCCHHHHHHHCCCCEEEEEECCEEEEE
LHRNETLEFNSLPLKYVAYTPCYRREAGSYGKDVRGMIRQHQFDKVELFWYTTPEESSQA
CCCCCCEEECCCCEEEEEECCHHHHHCCCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHH
LEELTSHAEKVLQLLNLPYRVVALCTGDLGFAAAKTYDLEVWLPSYNDYKEISSCSNTKD
HHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEEEEEECCCCCHHHHHHCCCCCC
FQGRRGNIRYRDRENKLNFVHTLNGSGLAVGRTLVAIMENYQTANGKIEIPEKLIPYMGK
CCCCCCCEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHH
EFIG
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA