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The map label for this gene is umuC [H]

Identifier: 160877508

GI number: 160877508

Start: 5208740

End: 5209996

Strand: Reverse

Name: umuC [H]

Synonym: Sbal195_4407

Alternate gene names: 160877508

Gene position: 5209996-5208740 (Counterclockwise)

Preceding gene: 160877509

Following gene: 160877507

Centisome position: 97.43

GC content: 45.19

Gene sequence:

>1257_bases
ATGTTTGCCTTGGTAGACGCCAACAGTTTCTATTGCAGTGCCGAGCAGGTATTTAGACCTGATTGGCGTGGTAAGCCAAT
GATTGTGTTGAGCAACAATGATGGCTGCATCGTAGCGGCAAACAAGCAAGCGAAAGAACGGGGTGTGCCTAAGTTTGCAC
CATACTTTCAAGTCAAAGACCTGTGTACGAAATTAGGTGTCATTGTTTGTTCAAGTAACTATGAGCTCTATGCCGATTTA
TCTGCAAAGATGATGAATATCATTGGCCGATTTGCACCAGAGCAGCATGTCTATTCGATTGATGAAAGCTTTCTCTCCTT
TAAAAATAGTTACCCCGCCATTAAGTGCTTACAAGCCCAAGGCCAGTTGATTCGAAAAGCGGTTTGGAAAGAAACACGTT
TACCGGTTTGTGTCGGTATCGGCTCAACACTCACACTGGCTAAAGCTGCCAATCATGCGGCAAAGAAGTTACCTGGCTAT
CAGGGTGTGTGTGCTATCGATAATGAACAAGACCGGATTTCAATTTTACAATCAATGAGTGTGAATGATGTCTGGGGCAT
TGGGCGCAGGATAAGCAAAAAACTTGAATTGATGAACGTAAGAACCGCCTATGACTTAGCAAAAATCCCTGCAGGTTTAG
CGCGAAAGCAATTTAGTATTGAAATAGAACGCACTGTGCGTGAACTCAATGGGCAAGCGTGCAAAGTGTGGGACGAGGCG
AGGGCGGATAAGAAGCAAATATTCTCAACTCGTAGTGTGGGCGAGCGTATTACCGAGTATGAGGATTTACTGCAAGCGTT
AAGTAAGCATGTGGCGATTGCCGCAGCGAAAGCGCGTAAGCAAGGTTCTAGCTGTAAAACCATGTTGTTGTTTGCCAGCA
ATTCTCCCTACGATGAACGCCCAACAGGCTTTAAGACCTTAGTGCACTTTGCTTGCGCCACTGATTGCAGCATTGAGCTT
ATTCAAGGGATGACACAAGCAGCATCTCAACTTTTCCGTGCAGGCGTACGTTATTACAAAGTCGGTGTAGGTCTGATTGA
TTTGGTCAGCACCCAGCATGGCCAGTTAGATTTATTCAATGTCTCAAAAGCCAAACCAGCATTAATGAAAACCCTCGATG
GCATCAATCAACGTTATGGTACTGATACCTTATTCATTGCCGCCCAAGGTATCGAGCAAAAATGGGCCATGCGTCGAGAT
TTACTCACACCGCAATACACTACCAAGTGGAAATGTCTGCCCGAGATAAAGTGTTGA

Upstream 100 bases:

>100_bases
AACCTCAGCCTATTCACGATTACGATAATTTTACCATTGAAGGTGTTGTTATTCGTTCTATTCGTTGTCATCGCCAAAGT
CCATTATTAGCAGACATCTG

Downstream 100 bases:

>100_bases
TATCTGACAGTAGATGGATTTATACGTTTATGCCCCAAAGCAATTCAGCGCTTTACTTTTAAACATCGCCTTACATTCAC
TTATGCATGAGATTTTGTAA

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNSYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCAIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVRTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
IQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHGQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLTPQYTTKWKCLPEIKC

Sequences:

>Translated_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNSYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCAIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVRTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
IQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHGQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLTPQYTTKWKCLPEIKC
>Mature_418_residues
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKDLCTKLGVIVCSSNYELYADL
SAKMMNIIGRFAPEQHVYSIDESFLSFKNSYPAIKCLQAQGQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGY
QGVCAIDNEQDRISILQSMSVNDVWGIGRRISKKLELMNVRTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDERPTGFKTLVHFACATDCSIEL
IQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHGQLDLFNVSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRD
LLTPQYTTKWKCLPEIKC

Specific function: Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template [H]

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Escherichia coli, GI1787432, Length=423, Percent_Identity=42.5531914893617, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1786425, Length=266, Percent_Identity=24.812030075188, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: NA

Molecular weight: Translated: 46641; Mature: 46641

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKD
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCHHHHHH
LCTKLGVIVCSSNYELYADLSAKMMNIIGRFAPEQHVYSIDESFLSFKNSYPAIKCLQAQ
HHHHCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
GQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGYQGVCAIDNEQDRISILQSMS
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCC
VNDVWGIGRRISKKLELMNVRTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEHHHHHHHHHCCCEEEHHHHH
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PTGFKTLVHFACATDCSIELIQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHGQLDLFN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHEECCCHHHHHHCCCCCCEEEEE
VSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRDLLTPQYTTKWKCLPEIKC
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFALVDANSFYCSAEQVFRPDWRGKPMIVLSNNDGCIVAANKQAKERGVPKFAPYFQVKD
CEEEEECCCCEECHHHHCCCCCCCCEEEEEECCCCEEEEECCHHHHCCCCCCCCHHHHHH
LCTKLGVIVCSSNYELYADLSAKMMNIIGRFAPEQHVYSIDESFLSFKNSYPAIKCLQAQ
HHHHCCEEEECCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
GQLIRKAVWKETRLPVCVGIGSTLTLAKAANHAAKKLPGYQGVCAIDNEQDRISILQSMS
HHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCC
VNDVWGIGRRISKKLELMNVRTAYDLAKIPAGLARKQFSIEIERTVRELNGQACKVWDEA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEHHHHHHHHHCCCEEEHHHHH
RADKKQIFSTRSVGERITEYEDLLQALSKHVAIAAAKARKQGSSCKTMLLFASNSPYDER
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
PTGFKTLVHFACATDCSIELIQGMTQAASQLFRAGVRYYKVGVGLIDLVSTQHGQLDLFN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHEECCCHHHHHHCCCCCCEEEEE
VSKAKPALMKTLDGINQRYGTDTLFIAAQGIEQKWAMRRDLLTPQYTTKWKCLPEIKC
CCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989817; 2989816; 8905232; 9278503; 1320188 [H]