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The map label for this gene is envZ [H]

Identifier: 160877441

GI number: 160877441

Start: 5128446

End: 5129735

Strand: Direct

Name: envZ [H]

Synonym: Sbal195_4339

Alternate gene names: 160877441

Gene position: 5128446-5129735 (Clockwise)

Preceding gene: 160877440

Following gene: 160877442

Centisome position: 95.91

GC content: 51.32

Gene sequence:

>1290_bases
ATGCCTCGCAGCGCGTTTAGCCAAACCGTGATGCTGATTGGTTGTCTATTACTGATCAATCAGCTGGTGTCTTACGTCAC
GGTTGCCGTCTATGTGCTTAAGCCAAGCTACCAACAAATCAATCAGTTAATCGCTCGCCAAGTCAAATTGCTGTTTGTCG
ATGGCATAGATATTGGCCGCGAACACTTAACCATAGTCGATGCCCTCAATGCCAAAGTCCACGACGATGGCATGAAGATC
TACAATCAGCAGCAGGCGCGCGAAGCCGGTATTGAGCAAGCGACCTACTATGGTTTCTGGTCGGCGCAGATGTCGGAATA
TCTCGGCGGCGACGCCGAAGTGCGTGTCACCCACGGCAGCGTATTGCAGATTTGGATCCGTCCACCACAGGCGCCCTCGA
TTTGGATAAAAGTGCCGCTGATTGGCCAAAATGTTTCAGATCTCTCGCCGCTCACCCTCTATTTAATGGTCATTGGTGCC
CTCAGCGTCGCCGGGGGTTGGTGGTTTGCCCGCCAACAAAACCGCCCACTTAGACGACTACAAAAAGCCGCGATTGCCGT
TTCCCGCGGTGAATTCCCCGAGCCCTTGCCGCTGAATGGTTCGAGTGAAATTGTCGAAGTGACTAACGCCTTCAACCAGA
TGGCGCACAGCATGAAACAACTGGAGCAGGACAGAGCGCTATTGATGGCGGGGATTTCCCACGACTTGCGCACGCCGCTC
ACCCGTATTCGGCTCGCTTCTGAGATGATGGTTGAGGAAGATCAATATCTTAAAGATGGCATAGTTAACGATATCGAAGA
TATGGACGCCATCATCAGCCAGTTTATTGCGTATATTCGCCAAGATCAGGAAACCAGCCGTGAGCTAGGGCAAATCAATA
AACTCATTCAAGATGTCGCTCAAGCAGAGGCCAATCGCGCCGGCGAAATTGAAGTAGTGTTAACTGACTGCCCAGAAGCC
CAATTCCAAGCGATTGCCATTAAACGGGTACTGAGCAACTTAGTCGAAAATGCCTTTCGCTATGGTTCTGGCTGGATCCG
CATTAGCTCGCAGTTCGACGGCAAACGTATCGGTTTTACTGTTGAAGATAATGGTCCAGGCATTGACGAGTCGCAAATAA
CCAAACTATTTCAACCATTTACCCAAGGTGATATCGCCCGAGGCAGTGTCGGCTCAGGCCTAGGTCTCGCCATCATCAAA
CGGATTATTGATAGACACCAAGGGCAAGTCACCCTCTCCAACCGCGCCGAAGGCGGTTTAAGAGCCCAAGTGTGGCTGCC
GCTGGAATAA

Upstream 100 bases:

>100_bases
GTTTGTGCCCGATGGCGCCGCGCGTCGATGAGCCGCATTGCCATCTTAATCTGCTGCGGTTATTGAGCCCCCGATGAAAC
CTAAGTTTTGGTGGCGGTTT

Downstream 100 bases:

>100_bases
CGCGAGATCACATATCGGCAAATCAAATGACAACGCTGACATTCATGTGGGCGCTTGTCATATTAATGTCACGCTAAATT
CATAAACTCAGAACAGTTAA

Product: osmolarity sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MPRSAFSQTVMLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQVKLLFVDGIDIGREHLTIVDALNAKVHDDGMKI
YNQQQAREAGIEQATYYGFWSAQMSEYLGGDAEVRVTHGSVLQIWIRPPQAPSIWIKVPLIGQNVSDLSPLTLYLMVIGA
LSVAGGWWFARQQNRPLRRLQKAAIAVSRGEFPEPLPLNGSSEIVEVTNAFNQMAHSMKQLEQDRALLMAGISHDLRTPL
TRIRLASEMMVEEDQYLKDGIVNDIEDMDAIISQFIAYIRQDQETSRELGQINKLIQDVAQAEANRAGEIEVVLTDCPEA
QFQAIAIKRVLSNLVENAFRYGSGWIRISSQFDGKRIGFTVEDNGPGIDESQITKLFQPFTQGDIARGSVGSGLGLAIIK
RIIDRHQGQVTLSNRAEGGLRAQVWLPLE

Sequences:

>Translated_429_residues
MPRSAFSQTVMLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQVKLLFVDGIDIGREHLTIVDALNAKVHDDGMKI
YNQQQAREAGIEQATYYGFWSAQMSEYLGGDAEVRVTHGSVLQIWIRPPQAPSIWIKVPLIGQNVSDLSPLTLYLMVIGA
LSVAGGWWFARQQNRPLRRLQKAAIAVSRGEFPEPLPLNGSSEIVEVTNAFNQMAHSMKQLEQDRALLMAGISHDLRTPL
TRIRLASEMMVEEDQYLKDGIVNDIEDMDAIISQFIAYIRQDQETSRELGQINKLIQDVAQAEANRAGEIEVVLTDCPEA
QFQAIAIKRVLSNLVENAFRYGSGWIRISSQFDGKRIGFTVEDNGPGIDESQITKLFQPFTQGDIARGSVGSGLGLAIIK
RIIDRHQGQVTLSNRAEGGLRAQVWLPLE
>Mature_428_residues
PRSAFSQTVMLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQVKLLFVDGIDIGREHLTIVDALNAKVHDDGMKIY
NQQQAREAGIEQATYYGFWSAQMSEYLGGDAEVRVTHGSVLQIWIRPPQAPSIWIKVPLIGQNVSDLSPLTLYLMVIGAL
SVAGGWWFARQQNRPLRRLQKAAIAVSRGEFPEPLPLNGSSEIVEVTNAFNQMAHSMKQLEQDRALLMAGISHDLRTPLT
RIRLASEMMVEEDQYLKDGIVNDIEDMDAIISQFIAYIRQDQETSRELGQINKLIQDVAQAEANRAGEIEVVLTDCPEAQ
FQAIAIKRVLSNLVENAFRYGSGWIRISSQFDGKRIGFTVEDNGPGIDESQITKLFQPFTQGDIARGSVGSGLGLAIIKR
IIDRHQGQVTLSNRAEGGLRAQVWLPLE

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=431, Percent_Identity=44.3155452436195, Blast_Score=366, Evalue=1e-102,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=29.0076335877863, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790551, Length=284, Percent_Identity=32.7464788732394, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788393, Length=289, Percent_Identity=26.9896193771626, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1790861, Length=286, Percent_Identity=29.020979020979, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786912, Length=238, Percent_Identity=31.0924369747899, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87082128, Length=250, Percent_Identity=26.8, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=249, Percent_Identity=27.3092369477912, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788279, Length=251, Percent_Identity=25.0996015936255, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI48994928, Length=223, Percent_Identity=26.9058295964126, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=26.1061946902655, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786783, Length=308, Percent_Identity=24.6753246753247, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=218, Percent_Identity=28.4403669724771, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=25.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87081816, Length=246, Percent_Identity=26.8292682926829, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=25.6227758007117, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1788713, Length=235, Percent_Identity=28.0851063829787, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=278, Percent_Identity=25.5395683453237, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47800; Mature: 47668

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRSAFSQTVMLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQVKLLFVDGIDIGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCC
EHLTIVDALNAKVHDDGMKIYNQQQAREAGIEQATYYGFWSAQMSEYLGGDAEVRVTHGS
HHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHCCCCCEEEEECCC
VLQIWIRPPQAPSIWIKVPLIGQNVSDLSPLTLYLMVIGALSVAGGWWFARQQNRPLRRL
EEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHH
QKAAIAVSRGEFPEPLPLNGSSEIVEVTNAFNQMAHSMKQLEQDRALLMAGISHDLRTPL
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TRIRLASEMMVEEDQYLKDGIVNDIEDMDAIISQFIAYIRQDQETSRELGQINKLIQDVA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QAEANRAGEIEVVLTDCPEAQFQAIAIKRVLSNLVENAFRYGSGWIRISSQFDGKRIGFT
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
VEDNGPGIDESQITKLFQPFTQGDIARGSVGSGLGLAIIKRIIDRHQGQVTLSNRAEGGL
ECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCC
RAQVWLPLE
EEEEEEECC
>Mature Secondary Structure 
PRSAFSQTVMLIGCLLLINQLVSYVTVAVYVLKPSYQQINQLIARQVKLLFVDGIDIGR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEECCCCCC
EHLTIVDALNAKVHDDGMKIYNQQQAREAGIEQATYYGFWSAQMSEYLGGDAEVRVTHGS
HHHHHHHHHCCEECCCHHHHHHHHHHHHCCCCHHHEEEEHHHHHHHHCCCCCEEEEECCC
VLQIWIRPPQAPSIWIKVPLIGQNVSDLSPLTLYLMVIGALSVAGGWWFARQQNRPLRRL
EEEEEECCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHH
QKAAIAVSRGEFPEPLPLNGSSEIVEVTNAFNQMAHSMKQLEQDRALLMAGISHDLRTPL
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
TRIRLASEMMVEEDQYLKDGIVNDIEDMDAIISQFIAYIRQDQETSRELGQINKLIQDVA
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
QAEANRAGEIEVVLTDCPEAQFQAIAIKRVLSNLVENAFRYGSGWIRISSQFDGKRIGFT
HHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEE
VEDNGPGIDESQITKLFQPFTQGDIARGSVGSGLGLAIIKRIIDRHQGQVTLSNRAEGGL
ECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCC
RAQVWLPLE
EEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]