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The map label for this gene is mtr [H]

Identifier: 160877409

GI number: 160877409

Start: 5088649

End: 5089905

Strand: Reverse

Name: mtr [H]

Synonym: Sbal195_4307

Alternate gene names: 160877409

Gene position: 5089905-5088649 (Counterclockwise)

Preceding gene: 160877410

Following gene: 160877408

Centisome position: 95.19

GC content: 48.85

Gene sequence:

>1257_bases
ATGGCAAATCATATGAATGCGGCTAAGCATAAGCCCGCAGGTAAGTCCTTGCTCGGTGGCGCCATGATTATTGCCGGTAC
GACCGTAGGTGCTGGGATGTTTTCTCTGCCCGTGGTCGGTGCAGGTATGTGGTTTGGCTATTCGATTTTAATGTTATTAG
GCATTTGGTTTTGCATGTTGATGTCGGGCTTATTGTTGCTCGAAACCAATTTGCATTTCGAACCGGGTGCCAGCTTCGAT
ACTTTAAGCAAGCAAACCTTAGGGCAGTTTTGGCGGATAGTGAACGGCGTTTCTATCGCGTTCGTGCTGTATATTTTGAC
TTATGCCTATATCAGCGGTGGTGGCTCGATTGTGAATCACAGCTTGCAGGGCATGGGAATTGAGTTACCGCAAAGTGTTG
CTGGGCTGGTGTTTGCCATAGTGTTGGCTAGTATCGTATTGATCAGCACTAAGGCCGTGGATCGCATTACCACGATTATG
CTCGGCGGTATGATCATTACCTTCTTCCTTGCAATCGGCAATTTACTGATCGAAATCGATGTGACTAAGTTGCTCGAACC
CGATGGTAATAATAGCTTTTCACCTTATCTGTGGGCGGCGCTACCCTTTGGTCTTGCCAGCTTTGGTTACCATGGTAACG
TCCCCAGCTTAGTGAAGTATTACGGCAAAGATTCTTCCACCATTATCAAGGCGATTTTCGTCGGCACCTTTATCGCGCTG
GTGATTTATGCATGTTGGTTAGTGGCGACTATGGGCAATATTCCCCGCAGCCAGTTTATCGATATTATTGCCCAAGGCGG
CAATATGGGCGTCTTGGTGGGCGCTTTGTCCGAGGTGATGGCGAGTAGCTGGTTGAACAGTATGTTAACGCTGTTTGCTA
ACTTGGCCGTGGCTTCATCTTTCTTAGGGGTAACCTTAGGTTTGTTTGATTATCTCGCCGACTTGTTTGGTTTTGACGAT
TCGCGCTCGGGCCGGATGAAAACCGCGTTAGTGACCTTTGTGCCGCCGACGATTTTAGGATTACTGTTCCCCGACGGCTT
TTTAGTGGCGATTGGCTTTGCGGCATTAGCGGCAACAGTGTGGGCGGTAATCGTCCCGGCGCTGATGGCCTATAAATCGC
GGCAGCTATTCCCCGAGAGCACAGGTTTTAGAGTGATAGGCGGTACACCGCTGATTATTCTTGTGGTGTTATTTGGCATA
GTCACGGGTGCTTGTCATCTGCTCGCGATGGCAAATTTACTGCCGCAATATTCCTAA

Upstream 100 bases:

>100_bases
AGTCCAATATCAATCGCATACGAGATCAAGCCAATAGCTTATTACGTCCGTCAGTGAAACAAACGATAGTGGCGAGTGTC
ACCGCGGAGCATACAGTTTA

Downstream 100 bases:

>100_bases
TTTGTTTCGATGATTTAAGCCCTCTGCGTGAGGGCTTTTTTGTATTTAGCGATTGAGTTTTAATCCTGCAGATCTTTTTT
ATCCCGACACTGGACAGAAG

Product: aromatic amino acid transporter

Products: Indole [Cytoplasm]; L-tryptophan [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Tryptophan permease [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MANHMNAAKHKPAGKSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSILMLLGIWFCMLMSGLLLLETNLHFEPGASFD
TLSKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIM
LGGMIITFFLAIGNLLIEIDVTKLLEPDGNNSFSPYLWAALPFGLASFGYHGNVPSLVKYYGKDSSTIIKAIFVGTFIAL
VIYACWLVATMGNIPRSQFIDIIAQGGNMGVLVGALSEVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDD
SRSGRMKTALVTFVPPTILGLLFPDGFLVAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFRVIGGTPLIILVVLFGI
VTGACHLLAMANLLPQYS

Sequences:

>Translated_418_residues
MANHMNAAKHKPAGKSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSILMLLGIWFCMLMSGLLLLETNLHFEPGASFD
TLSKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIM
LGGMIITFFLAIGNLLIEIDVTKLLEPDGNNSFSPYLWAALPFGLASFGYHGNVPSLVKYYGKDSSTIIKAIFVGTFIAL
VIYACWLVATMGNIPRSQFIDIIAQGGNMGVLVGALSEVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDD
SRSGRMKTALVTFVPPTILGLLFPDGFLVAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFRVIGGTPLIILVVLFGI
VTGACHLLAMANLLPQYS
>Mature_417_residues
ANHMNAAKHKPAGKSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSILMLLGIWFCMLMSGLLLLETNLHFEPGASFDT
LSKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNHSLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIML
GGMIITFFLAIGNLLIEIDVTKLLEPDGNNSFSPYLWAALPFGLASFGYHGNVPSLVKYYGKDSSTIIKAIFVGTFIALV
IYACWLVATMGNIPRSQFIDIIAQGGNMGVLVGALSEVMASSWLNSMLTLFANLAVASSFLGVTLGLFDYLADLFGFDDS
RSGRMKTALVTFVPPTILGLLFPDGFLVAIGFAALAATVWAVIVPALMAYKSRQLFPESTGFRVIGGTPLIILVVLFGIV
TGACHLLAMANLLPQYS

Specific function: Involved in transporting tryptophan across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789552, Length=387, Percent_Identity=58.3979328165375, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1790145, Length=416, Percent_Identity=46.3942307692308, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788218, Length=400, Percent_Identity=37.5, Blast_Score=250, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44400; Mature: 44269

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHMNAAKHKPAGKSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSILMLLGIWFCML
CCCCCCCCCCCCCCCHHHCCCCEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSGLLLLETNLHFEPGASFDTLSKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNH
HHCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIMLGGMIITFFLAIGNLLIEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTKLLEPDGNNSFSPYLWAALPFGLASFGYHGNVPSLVKYYGKDSSTIIKAIFVGTFIAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYACWLVATMGNIPRSQFIDIIAQGGNMGVLVGALSEVMASSWLNSMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDDSRSGRMKTALVTFVPPTILGLLFPDGFLVAIGFAALAATV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WAVIVPALMAYKSRQLFPESTGFRVIGGTPLIILVVLFGIVTGACHLLAMANLLPQYS
HHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANHMNAAKHKPAGKSLLGGAMIIAGTTVGAGMFSLPVVGAGMWFGYSILMLLGIWFCML
CCCCCCCCCCCCCCHHHCCCCEEECCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MSGLLLLETNLHFEPGASFDTLSKQTLGQFWRIVNGVSIAFVLYILTYAYISGGGSIVNH
HHCHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
SLQGMGIELPQSVAGLVFAIVLASIVLISTKAVDRITTIMLGGMIITFFLAIGNLLIEID
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE
VTKLLEPDGNNSFSPYLWAALPFGLASFGYHGNVPSLVKYYGKDSSTIIKAIFVGTFIAL
HHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHH
VIYACWLVATMGNIPRSQFIDIIAQGGNMGVLVGALSEVMASSWLNSMLTLFANLAVASS
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLGVTLGLFDYLADLFGFDDSRSGRMKTALVTFVPPTILGLLFPDGFLVAIGFAALAATV
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
WAVIVPALMAYKSRQLFPESTGFRVIGGTPLIILVVLFGIVTGACHLLAMANLLPQYS
HHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Indole [Periplasm]; L-tryptophan [Periplasm]; Proton [Periplasm] [C]

Specific reaction: Proton [Periplasm] + indole [Periplasm] = Proton [Cytoplasm] + indole [Cytoplasm] L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1987112; 2061290; 9278503; 1904443; 7814318 [H]