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The map label for this gene is ilvY [H]

Identifier: 160877234

GI number: 160877234

Start: 4889183

End: 4890055

Strand: Direct

Name: ilvY [H]

Synonym: Sbal195_4130

Alternate gene names: 160877234

Gene position: 4889183-4890055 (Clockwise)

Preceding gene: 160877226

Following gene: 160877238

Centisome position: 91.43

GC content: 53.04

Gene sequence:

>873_bases
ATGGATATTCGTACCCTCAAATTGTACCTGCACTTATGTGACAGTTTGCACTTCGCCAAGACAGCGGAACAGATGCATGT
GAGCCCATCGACCTTAAGCCGAGCCCTGCAAAGATTAGAAGAAGAAGTGAACGCTAAGCTATTAGAGCGGGATAATCGCA
GCGTGACCTTAACCCACGCGGGACACGAGTTTAAGCGGTTCGCCGAGCAGACTTTGAACCATTGGAGCACACTCAAGCAC
AGTATCGATCTCAAGCAGGACGTACTGCGTGGTCGGTTGAATCTGTATTGCTCGGTCACCGCCGCCTATAGCCATTTACC
AGGTTTATTGGATTTATTCCGCCAAGAACATCCCTTCGTCGAAATCGCCTTAACCACGGGAGATGCGGCGAACGCGCTGG
CCGAAGTGCAACAGAATCGCGCCGATATCGCCATCGCCGCCCTGCCCGATCCGTTTCCCAGCAGCTTACACTTTGCCAAA
ATCGATGATGTGCCGCTGTCGATTATCGCCCCAACTATCCGATGCGCGGTGCAGCAGCAAATTTCCCAAACGCCCATCGA
TTGGTCGAGCGTGCCCTTTATCATTCCCGACCACGGGCCCGGACGTCGCCGCGCCGATAACTGGTTCAAACAAATGGGCA
TCAGCCCTAATATTTACGCCCAAGTATCGGGCCAAGAAGCGATAGCCTCTATGGTGGCGTTAGGCTGCGGTGTGAGTATG
AGCCCAGAGGTGGTAATCAATAACAGCCCAGTGCGGGATCGCATTCAGCTGCTCTCGTCGCCGGTTGCGATTCCACCGTT
CGAGTTAGGTTGCTGCTGCAAAGTAAAACGGCTCGACGATCCCATAGTCAATGCGTTTTTGGATGTGATTTAA

Upstream 100 bases:

>100_bases
TCAACTGCAATCATGAGCAGTAACATCGGCGCCAATATGCGGTCCCCAATCACGCCGTCACTCAAGCCAAGGCTCAAGCT
CAGACTAAACAGGATAAGTC

Downstream 100 bases:

>100_bases
ACGGGGAAAGTAATACAAAAATAAAGTGCGAGTGAAGTGTTTCAACGATATATAAAGCCGAAACGGCTCTCAAAAAGCTA
AAAACTTAGCGAAAGAGAAC

Product: DNA-binding transcriptional regulator IlvY

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLLERDNRSVTLTHAGHEFKRFAEQTLNHWSTLKH
SIDLKQDVLRGRLNLYCSVTAAYSHLPGLLDLFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPSSLHFAK
IDDVPLSIIAPTIRCAVQQQISQTPIDWSSVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSM
SPEVVINNSPVRDRIQLLSSPVAIPPFELGCCCKVKRLDDPIVNAFLDVI

Sequences:

>Translated_290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLLERDNRSVTLTHAGHEFKRFAEQTLNHWSTLKH
SIDLKQDVLRGRLNLYCSVTAAYSHLPGLLDLFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPSSLHFAK
IDDVPLSIIAPTIRCAVQQQISQTPIDWSSVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSM
SPEVVINNSPVRDRIQLLSSPVAIPPFELGCCCKVKRLDDPIVNAFLDVI
>Mature_290_residues
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLLERDNRSVTLTHAGHEFKRFAEQTLNHWSTLKH
SIDLKQDVLRGRLNLYCSVTAAYSHLPGLLDLFRQEHPFVEIALTTGDAANALAEVQQNRADIAIAALPDPFPSSLHFAK
IDDVPLSIIAPTIRCAVQQQISQTPIDWSSVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSM
SPEVVINNSPVRDRIQLLSSPVAIPPFELGCCCKVKRLDDPIVNAFLDVI

Specific function: This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790208, Length=293, Percent_Identity=52.2184300341297, Blast_Score=303, Evalue=9e-84,
Organism=Escherichia coli, GI1790399, Length=258, Percent_Identity=24.4186046511628, Blast_Score=77, Evalue=9e-16,
Organism=Escherichia coli, GI1787806, Length=261, Percent_Identity=21.8390804597701, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788887, Length=252, Percent_Identity=26.1904761904762, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787879, Length=246, Percent_Identity=25.2032520325203, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=245, Percent_Identity=22.4489795918367, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=21.6326530612245, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788296, Length=236, Percent_Identity=27.1186440677966, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789639, Length=268, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI145693105, Length=165, Percent_Identity=24.2424242424242, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1786508, Length=135, Percent_Identity=30.3703703703704, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788706, Length=157, Percent_Identity=31.8471337579618, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI157672245, Length=235, Percent_Identity=20.4255319148936, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786401, Length=142, Percent_Identity=26.7605633802817, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32187; Mature: 32187

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLLERDNRSVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GHEFKRFAEQTLNHWSTLKHSIDLKQDVLRGRLNLYCSVTAAYSHLPGLLDLFRQEHPFV
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEHHHHHHCHHHHHHHHCCCCEE
EIALTTGDAANALAEVQQNRADIAIAALPDPFPSSLHFAKIDDVPLSIIAPTIRCAVQQQ
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
ISQTPIDWSSVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSM
HHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCC
SPEVVINNSPVRDRIQLLSSPVAIPPFELGCCCKVKRLDDPIVNAFLDVI
CCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHHHHHCC
>Mature Secondary Structure
MDIRTLKLYLHLCDSLHFAKTAEQMHVSPSTLSRALQRLEEEVNAKLLERDNRSVTLTHA
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
GHEFKRFAEQTLNHWSTLKHSIDLKQDVLRGRLNLYCSVTAAYSHLPGLLDLFRQEHPFV
CHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHEEEEEHHHHHHCHHHHHHHHCCCCEE
EIALTTGDAANALAEVQQNRADIAIAALPDPFPSSLHFAKIDDVPLSIIAPTIRCAVQQQ
EEEEECCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHH
ISQTPIDWSSVPFIIPDHGPGRRRADNWFKQMGISPNIYAQVSGQEAIASMVALGCGVSM
HHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCCC
SPEVVINNSPVRDRIQLLSSPVAIPPFELGCCCKVKRLDDPIVNAFLDVI
CCCEEECCCCHHHHHHHHHCCCCCCCCCCCCEEEHHHCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3003115; 1379743; 9278503; 3550695 [H]