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The map label for this gene is folM [H]

Identifier: 160876911

GI number: 160876911

Start: 4487881

End: 4488627

Strand: Reverse

Name: folM [H]

Synonym: Sbal195_3807

Alternate gene names: 160876911

Gene position: 4488627-4487881 (Counterclockwise)

Preceding gene: 160876913

Following gene: 160876908

Centisome position: 83.94

GC content: 49.4

Gene sequence:

>747_bases
ATGACATCTCCCATCATAATCACAGGCGTGGGTAAACGCATAGGTTACGCCTTAGCCAAACATTTTCTCGCCCAAGGTCA
GCAGGTGATTGGTACTTATCGCAGCCATTACGATAGCATTGATGAGCTGAACGCTTTAGGTGCGACTCTGTATCCCTGCG
ATTTTTATGACGATGCCCAAGTGCAATCCTTAATTGATGAGTTAACTCAACTGCCTCAAATTCGCGCCATTATTCACAAT
GCTTCGGACTGGCTGCCGGATCCTGTTCTTATAAAGAATGAGCCTTTAAAGAGTACCACTTTTACGCCGAGCCAAGTGCT
GCAGCGGATGATGCAAGTGCATGTGAGCGTGCCCTATCAGTTGAACTTGGCCTTAGAGGCGCAGCTACGTGCCGCTGCTG
GCGATGAAATCGGCGGCAGTGATGTGATTCATATTACAGACTACGTGGCAGAGAAGGGCAGTCAGAAGCACATAGCCTAT
GCCGCCAGTAAAGCCGCGCTGCACAATATGACGCTATCCTTTGCCGCCAAATTTGCGCCCGAGGTGAAAGTCAATTCGAT
TGCACCAGCGATGATCCTATTTAATATGGGTGATGACGCCGCCTATCAGCAAAAAACCTTAGCCAAAGCGTTATTACCGA
AAGAGGCGGGGAATGCGGAGATTATCGAACTAGTGGACTACCTGCTCAATAGCCGTTACGTCACCGGTCGTTGCCATAAT
GTCGACGGCGGCCGGCAGTTAAAATAG

Upstream 100 bases:

>100_bases
GAGTACAGTAACATCTTGGTTATTCATCAGGTTAACTTGATTGCTTATCTTTAAGTGAACAAGGTAAAGCCTGACAAATA
ACGGACTCAAAAGGATAGGT

Downstream 100 bases:

>100_bases
TCATTTGATTTTTCGAGCAACAGCTAATGGCTTAAAACGTCAGTACGCGACTTGGGGTGATGATGAATGGCAAAGGCACA
TCCCAATGCTCGCAGGGTAA

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTSPIIITGVGKRIGYALAKHFLAQGQQVIGTYRSHYDSIDELNALGATLYPCDFYDDAQVQSLIDELTQLPQIRAIIHN
ASDWLPDPVLIKNEPLKSTTFTPSQVLQRMMQVHVSVPYQLNLALEAQLRAAAGDEIGGSDVIHITDYVAEKGSQKHIAY
AASKAALHNMTLSFAAKFAPEVKVNSIAPAMILFNMGDDAAYQQKTLAKALLPKEAGNAEIIELVDYLLNSRYVTGRCHN
VDGGRQLK

Sequences:

>Translated_248_residues
MTSPIIITGVGKRIGYALAKHFLAQGQQVIGTYRSHYDSIDELNALGATLYPCDFYDDAQVQSLIDELTQLPQIRAIIHN
ASDWLPDPVLIKNEPLKSTTFTPSQVLQRMMQVHVSVPYQLNLALEAQLRAAAGDEIGGSDVIHITDYVAEKGSQKHIAY
AASKAALHNMTLSFAAKFAPEVKVNSIAPAMILFNMGDDAAYQQKTLAKALLPKEAGNAEIIELVDYLLNSRYVTGRCHN
VDGGRQLK
>Mature_247_residues
TSPIIITGVGKRIGYALAKHFLAQGQQVIGTYRSHYDSIDELNALGATLYPCDFYDDAQVQSLIDELTQLPQIRAIIHNA
SDWLPDPVLIKNEPLKSTTFTPSQVLQRMMQVHVSVPYQLNLALEAQLRAAAGDEIGGSDVIHITDYVAEKGSQKHIAYA
ASKAALHNMTLSFAAKFAPEVKVNSIAPAMILFNMGDDAAYQQKTLAKALLPKEAGNAEIIELVDYLLNSRYVTGRCHNV
DGGRQLK

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=246, Percent_Identity=53.6585365853659, Blast_Score=236, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24643142, Length=248, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 27165; Mature: 27034

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIIITGVGKRIGYALAKHFLAQGQQVIGTYRSHYDSIDELNALGATLYPCDFYDDAQ
CCCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHCCCEEECCCCCCCHH
VQSLIDELTQLPQIRAIIHNASDWLPDPVLIKNEPLKSTTFTPSQVLQRMMQVHVSVPYQ
HHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEE
LNLALEAQLRAAAGDEIGGSDVIHITDYVAEKGSQKHIAYAASKAALHNMTLSFAAKFAP
EEEEEEEHHHHHCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EVKVNSIAPAMILFNMGDDAAYQQKTLAKALLPKEAGNAEIIELVDYLLNSRYVTGRCHN
CCEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECEEEC
VDGGRQLK
CCCCCCCC
>Mature Secondary Structure 
TSPIIITGVGKRIGYALAKHFLAQGQQVIGTYRSHYDSIDELNALGATLYPCDFYDDAQ
CCCEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHCCCEEECCCCCCCHH
VQSLIDELTQLPQIRAIIHNASDWLPDPVLIKNEPLKSTTFTPSQVLQRMMQVHVSVPYQ
HHHHHHHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCEE
LNLALEAQLRAAAGDEIGGSDVIHITDYVAEKGSQKHIAYAASKAALHNMTLSFAAKFAP
EEEEEEEHHHHHCCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
EVKVNSIAPAMILFNMGDDAAYQQKTLAKALLPKEAGNAEIIELVDYLLNSRYVTGRCHN
CCEECCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEECEEEC
VDGGRQLK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA