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The map label for this gene is hpt [H]

Identifier: 160876817

GI number: 160876817

Start: 4381456

End: 4382028

Strand: Reverse

Name: hpt [H]

Synonym: Sbal195_3713

Alternate gene names: 160876817

Gene position: 4382028-4381456 (Counterclockwise)

Preceding gene: 160876818

Following gene: 160876816

Centisome position: 81.95

GC content: 45.9

Gene sequence:

>573_bases
ATGACAAACAGTCTAACCGCGACCTCGACAATTGAGACTTATATGAAACACACCACCGAAGTGATGATCTCTGCAGAAGA
GATAAGCCAGAAATTGGATCAAATGGCCGAGCTAATCAATGCCCATTATGCCCACAGCGAACGTCTGCTGATGGTAGGCT
TGTTAAAAGGCTCAGTGGTCTTTATGGCTGACCTGTGTCGCCGAATTAAAGGCCATGTTGAAATCGATTTTATGTCGGTT
TCCAGTTATGGCAATGCTATGACCAGCTCACGGGATGTGAAAGTGCTGAAAGATGTGCAATCAGATATCGCCGGTCGCGA
TGTATTGATTGTGGAAGACTTGATTGACTCAGGTAACACCTTAAGCAAAGTGCGCGAGATGCTGTTACTGCGCGAGCCTA
AGAGCCTTGCACTGTGCACCCTGCTGGATAAACCAGAACGTCGTGAAGTGGATGTGAAGGTCGATTTTATCGGTTTCACT
ATCCCTGATGAGTTTATCGTGGGTTATGGTATTGATTATGCAGAGCAATATCGCAATCTACCTTACATCGCGAAAGTCGT
GCCACTCGATTAA

Upstream 100 bases:

>100_bases
TATCACAATCCCAAATCGGTTGAAGATCTGGTAGACTTCATGGCCGCTCGAATTCTCGATCATTTGGGCGTTGACCATGC
ATTAACGAGTCGCTGGGGTT

Downstream 100 bases:

>100_bases
GTGTCCGATACCGTTTAAAACTCCCGCAACAGGCGGGAGTTTTGCTTTTTACGGTTATATAAAAAATAGTATAAATAATT
GAACCATTAAAGATTGGTTT

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 190; Mature: 189

Protein sequence:

>190_residues
MTNSLTATSTIETYMKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSV
SSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFT
IPDEFIVGYGIDYAEQYRNLPYIAKVVPLD

Sequences:

>Translated_190_residues
MTNSLTATSTIETYMKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSV
SSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFT
IPDEFIVGYGIDYAEQYRNLPYIAKVVPLD
>Mature_189_residues
TNSLTATSTIETYMKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVVFMADLCRRIKGHVEIDFMSVS
SYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNTLSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTI
PDEFIVGYGIDYAEQYRNLPYIAKVVPLD

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=174, Percent_Identity=35.0574712643678, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI9910262, Length=185, Percent_Identity=29.1891891891892, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI87081689, Length=177, Percent_Identity=63.8418079096045, Blast_Score=239, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI17510817, Length=176, Percent_Identity=31.25, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 21365; Mature: 21234

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSLTATSTIETYMKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVV
CCCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHH
FMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNT
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHCCCCH
LSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNL
HHHHHHHHHHCCCCHHEEEHCCCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCC
PYIAKVVPLD
CCEEEEECCC
>Mature Secondary Structure 
TNSLTATSTIETYMKHTTEVMISAEEISQKLDQMAELINAHYAHSERLLMVGLLKGSVV
CCCCCHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHH
FMADLCRRIKGHVEIDFMSVSSYGNAMTSSRDVKVLKDVQSDIAGRDVLIVEDLIDSGNT
HHHHHHHHHCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHHCCCCH
LSKVREMLLLREPKSLALCTLLDKPERREVDVKVDFIGFTIPDEFIVGYGIDYAEQYRNL
HHHHHHHHHHCCCCHHEEEHCCCCCCCCEEEEEEEEEEEECCCHHHEECCCCHHHHHCCC
PYIAKVVPLD
CCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]