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The map label for this gene is ada [H]

Identifier: 160876050

GI number: 160876050

Start: 3485150

End: 3486847

Strand: Reverse

Name: ada [H]

Synonym: Sbal195_2940

Alternate gene names: 160876050

Gene position: 3486847-3485150 (Counterclockwise)

Preceding gene: 160876053

Following gene: 160876049

Centisome position: 65.21

GC content: 49.41

Gene sequence:

>1698_bases
ATGAGTACAGATAGATCGTCTGAGAGTGCGATTAAGCGTGATGAAATAGACTCAGTGCATTCACTGGAATCCAGTGCGGG
GCTACTTTCTGCGTCTATTTGCCGTGAGGCGAGGATGAGCCGCGATCCGCGTTTTGATGGTAAGTTTTTTGTGGGCGTAT
TAACGACGGGCATTTATTGCCGTACCGTGTGTCCCGCCGTCGCGCCAAAAGAGCAGAATGTGCGTTATTTTGATTCGGCC
GTGAAAGCCGCACAGGCGGGATTACGCCCGTGTTTGCGTTGTCGGCCCGACAGTGCGCCAGGTTCAAATCCGTGGAAAGG
CACAGGCACGACATTGGCGAGGGCCATTAGTTTAATTGAAGCTGGCGCATTAGCGGGGAAATCATCGGGAGAGCCTGCCT
CGACTGTGACACAATTGGCTGACAGATTAGGGATCAGTAGTCGTTATCTCAATAAGCTCTTTACCGAAGGTTTTGGCACT
TCGCCTAAACAATATGCCTTATACAGGCAGTTACTGTTTGCAAAACAACTGCTACATCAAACCCAATTACCTATCACCCA
AGTCGCGCTGGCGGCGGGTTTCAACAGTATTCGCCGTTTCAATGAGGCATTTAAGCAAACCTTACAATTGACGCCAACGC
AATTAAGAAAGACCGCTTTAACCAAGGCGGCAAAGGAGCATGTTGTTGGACGAACAACAGGATTCGGTGAAATTGATACT
TTGGGTGAATTTGTGCCGCACTATGGATTAACCCTATATCAATACTATCGCCCCCCATTGGATTGGGCATCGCAGCTGGC
ATTTTATCGCTTACGTGCGGTGACAGGGATGGAGTGGTTCACGCCGCAAATGAGTCACCCACAAGCGAGTGATGCAGTTC
AGATTGCAGATGAAACCAATGTTTCAGCAGAAGCCAAGGCTGACGAGAACGGGCTCGAATATGGTCGCTGTTTTGCCATC
GGCAAGATGCGCGGCACAGTGCACATTATCCATGAGCCTAAGCTGAATCGTTTCAAACTTGCGATTGCTTTGACCGAAGA
TTCCGCCGTTGATGAGCTGCAATTGATGGTCACTGAGGTGCGGCGCATTTTAGATCTCGATGCGGATATGCAGCAGATTG
AGCAAGGTTTAAGTACGCTGCCGAGTTTAGGTTTAACACCGTTTTCGGGATTGCGCATTCCTGGCGCAGGATCTTTGTTT
GAAGCGGTTTGCCGCGCGATTTTGGGCCAGCAAGTGACGGTCGTGCAGGCAACTAAGTTACTGAATATATTGGTTGAAGC
CTATGGCGAGTGTTTTAGTCTCAATGGCCGCGAGTATCGATTATTCCCAACACCCGAGGCGATTCGTGAGGCGAGTTTAA
CTGAGCTAAAAATGCCGGGCGCCCGTAAATTAGCGCTCAATGCGCTCGCGGCGTTTATCTGCGAACATCCTGAGGCGAGT
GTCGATGATTGGCTTAGCGTTAAAGGCATAGGTCCTTGGACGATAGCGTATGCCAAGCTTCGTGGCTTGGGCGATCCAAA
CGTGTTTTTACATTCGGATTTGATTGTTAAAAAGCATTTATTGGCCTTATATATCAAGAACAATAAGTTAGATGAAACGG
CCGCCGCGGCAGTGAGCTATCCCCAATTGTGCGAGCAGCTGAGTCAACAAATTGCCCCGTGGGGCAGTTACTTAACCTTT
CAGCTCTGGCATCAATAA

Upstream 100 bases:

>100_bases
ATGATTGAGTTCCGTTTTCCGCTAGTGCTACATGCTAGTTTTACGTAAAGTAATGAACAAGAAGTTAATTGTGAGCGAAT
ATTGTCGGGCGTGATGAAAA

Downstream 100 bases:

>100_bases
CCATCAAGCCGCCTCATATTGAACTGCCAGTTTAAAAAGATGAGTTAGCAGTTCAGTTAAGTACCAAATTAAGATCAAAC
AAAGAGCAAACGAAGAGACA

Product: AraC family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein of adaptative response; Methylated-DNA--protein-cysteine methyltransferase; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MSTDRSSESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
VKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKAAKEHVVGRTTGFGEIDT
LGEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQIADETNVSAEAKADENGLEYGRCFAI
GKMRGTVHIIHEPKLNRFKLAIALTEDSAVDELQLMVTEVRRILDLDADMQQIEQGLSTLPSLGLTPFSGLRIPGAGSLF
EAVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEAS
VDDWLSVKGIGPWTIAYAKLRGLGDPNVFLHSDLIVKKHLLALYIKNNKLDETAAAAVSYPQLCEQLSQQIAPWGSYLTF
QLWHQ

Sequences:

>Translated_565_residues
MSTDRSSESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSA
VKAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGT
SPKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKAAKEHVVGRTTGFGEIDT
LGEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQIADETNVSAEAKADENGLEYGRCFAI
GKMRGTVHIIHEPKLNRFKLAIALTEDSAVDELQLMVTEVRRILDLDADMQQIEQGLSTLPSLGLTPFSGLRIPGAGSLF
EAVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEAS
VDDWLSVKGIGPWTIAYAKLRGLGDPNVFLHSDLIVKKHLLALYIKNNKLDETAAAAVSYPQLCEQLSQQIAPWGSYLTF
QLWHQ
>Mature_564_residues
STDRSSESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYCRTVCPAVAPKEQNVRYFDSAV
KAAQAGLRPCLRCRPDSAPGSNPWKGTGTTLARAISLIEAGALAGKSSGEPASTVTQLADRLGISSRYLNKLFTEGFGTS
PKQYALYRQLLFAKQLLHQTQLPITQVALAAGFNSIRRFNEAFKQTLQLTPTQLRKTALTKAAKEHVVGRTTGFGEIDTL
GEFVPHYGLTLYQYYRPPLDWASQLAFYRLRAVTGMEWFTPQMSHPQASDAVQIADETNVSAEAKADENGLEYGRCFAIG
KMRGTVHIIHEPKLNRFKLAIALTEDSAVDELQLMVTEVRRILDLDADMQQIEQGLSTLPSLGLTPFSGLRIPGAGSLFE
AVCRAILGQQVTVVQATKLLNILVEAYGECFSLNGREYRLFPTPEAIREASLTELKMPGARKLALNALAAFICEHPEASV
DDWLSVKGIGPWTIAYAKLRGLGDPNVFLHSDLIVKKHLLALYIKNNKLDETAAAAVSYPQLCEQLSQQIAPWGSYLTFQ
LWHQ

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788383, Length=324, Percent_Identity=28.7037037037037, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1788542, Length=178, Percent_Identity=30.8988764044944, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR010316
- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR023170
- InterPro:   IPR012294 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF06029 AlkA_N; PF00730 HhH-GPD [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 62176; Mature: 62045

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
STDRSSESAIKRDEIDSVHSLESSAGLLSASICREARMSRDPRFDGKFFVGVLTTGIYC
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHH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HHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]