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The map label for this gene is mdtE [H]

Identifier: 160875979

GI number: 160875979

Start: 3418915

End: 3419928

Strand: Direct

Name: mdtE [H]

Synonym: Sbal195_2869

Alternate gene names: 160875979

Gene position: 3418915-3419928 (Clockwise)

Preceding gene: 160875978

Following gene: 160875980

Centisome position: 63.94

GC content: 49.8

Gene sequence:

>1014_bases
ATGACGTCAATTTCTCGCGCATTTTTCTTACTCTTGGCACTTGCCAGTACTCAAGTCCAGGCTGCCTCAGTCGAAACCAT
CGAAGTCTTAACTAAACCCTACGCTAATTGGGTCACCTTAGATGCCACCATAGAAGCAGTAAAAGCGGCGACTGTGTCAG
CGCAAACCTCTGGCCGTATCGTCAAACTCAACTACGATGTTAATGATGTTGTCCCCGAGGGAGCCGCCCTACTGGAGATA
ACCAGTAAAGAACAAGGCGCTGAACTCGCAAGCTTTGAGGCCGATTTAGCCAAAGCCAAAGCCTTGAATGTGGAAGCACA
GGCGCAATACAAACGTTATAAAGAGTTATTCCCCCAAGGCGCGATTTCTAAGGGCGCAATGGATGAAGCCACCGCCAATG
CTAAGGCCACAGAGCAAGCCGTAACCGCAGCGCAAGCCCGCGTCATCAAAGCCAGCGAATCCTTAAAATACACTGTGGTA
TCAGCACCTTTTAGTGGTGTAGTCACAGAGCGTTTTGTCGAACTGGGCGAAACCGTGAGCCCAGGACAAGCACTACTTTC
AGGGTTTTCCGCGAGTCAAATGCGCGCCATTACCCAAGTGCCGCAGCGCTATATCAACCAGCTGAAAATCGCTCCCGAAT
TCCTCGTCCGTTTAAGTGATGGCCGCGAGTTAACCTCAAAGGATCTCACTATTTTTAGTTTTGCCGATCCCGTCAGCCAC
AGTTACCAAGTGCGCATTAATCTGCCTGAAAATGAAGCTAATCTTCAACCCGGTACTTGGGCAAAGGCTTCCTTTAAAAA
TGGCGAGCGAGAAAAAATCCAATTGCCCACCTCTGCGCTACTGACAATGAACGAACTGAGCAGCGTTTACCTTAAAAAGG
GCGAAGAATTTGTACTCACCCAAGTCCGTGTCGCTAGTCCCTTAGATGGCGAGGTCGAAGTGCTGGCGGGCCTGAAGTCG
GGCGACAAGGTTGCCGTTGATGCCTACCAAGTGTTGCTCAACAAAAAGCAATAA

Upstream 100 bases:

>100_bases
GAAATACACTATATTAAATTTTTCTAATAAATATTGATTGCCTATTGAAAACAACTCCATTAGAATTTACTCATGAATTA
CATCTGGGATGATATAAATT

Downstream 100 bases:

>100_bases
ATTCCCTAGCGACTTAAGCTTTGTCGAGGTTGTTTTATGAAACATGCTCCAGTACCACAGACCACACTTGGGATTTCCGG
TCGAATTGCCGCCGCCTTCC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTSISRAFFLLLALASTQVQAASVETIEVLTKPYANWVTLDATIEAVKAATVSAQTSGRIVKLNYDVNDVVPEGAALLEI
TSKEQGAELASFEADLAKAKALNVEAQAQYKRYKELFPQGAISKGAMDEATANAKATEQAVTAAQARVIKASESLKYTVV
SAPFSGVVTERFVELGETVSPGQALLSGFSASQMRAITQVPQRYINQLKIAPEFLVRLSDGRELTSKDLTIFSFADPVSH
SYQVRINLPENEANLQPGTWAKASFKNGEREKIQLPTSALLTMNELSSVYLKKGEEFVLTQVRVASPLDGEVEVLAGLKS
GDKVAVDAYQVLLNKKQ

Sequences:

>Translated_337_residues
MTSISRAFFLLLALASTQVQAASVETIEVLTKPYANWVTLDATIEAVKAATVSAQTSGRIVKLNYDVNDVVPEGAALLEI
TSKEQGAELASFEADLAKAKALNVEAQAQYKRYKELFPQGAISKGAMDEATANAKATEQAVTAAQARVIKASESLKYTVV
SAPFSGVVTERFVELGETVSPGQALLSGFSASQMRAITQVPQRYINQLKIAPEFLVRLSDGRELTSKDLTIFSFADPVSH
SYQVRINLPENEANLQPGTWAKASFKNGEREKIQLPTSALLTMNELSSVYLKKGEEFVLTQVRVASPLDGEVEVLAGLKS
GDKVAVDAYQVLLNKKQ
>Mature_336_residues
TSISRAFFLLLALASTQVQAASVETIEVLTKPYANWVTLDATIEAVKAATVSAQTSGRIVKLNYDVNDVVPEGAALLEIT
SKEQGAELASFEADLAKAKALNVEAQAQYKRYKELFPQGAISKGAMDEATANAKATEQAVTAAQARVIKASESLKYTVVS
APFSGVVTERFVELGETVSPGQALLSGFSASQMRAITQVPQRYINQLKIAPEFLVRLSDGRELTSKDLTIFSFADPVSHS
YQVRINLPENEANLQPGTWAKASFKNGEREKIQLPTSALLTMNELSSVYLKKGEEFVLTQVRVASPLDGEVEVLAGLKSG
DKVAVDAYQVLLNKKQ

Specific function: Part of a multidrug resistance efflux system that confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789929, Length=302, Percent_Identity=25.1655629139073, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081951, Length=188, Percent_Identity=32.4468085106383, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786668, Length=338, Percent_Identity=28.4023668639053, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082036, Length=308, Percent_Identity=25.3246753246753, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 36408; Mature: 36277

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSISRAFFLLLALASTQVQAASVETIEVLTKPYANWVTLDATIEAVKAATVSAQTSGRI
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHEEECCCCEE
VKLNYDVNDVVPEGAALLEITSKEQGAELASFEADLAKAKALNVEAQAQYKRYKELFPQG
EEEECCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AISKGAMDEATANAKATEQAVTAAQARVIKASESLKYTVVSAPFSGVVTERFVELGETVS
CCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCC
PGQALLSGFSASQMRAITQVPQRYINQLKIAPEFLVRLSDGRELTSKDLTIFSFADPVSH
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCEECCCCEEEEEECCCCCC
SYQVRINLPENEANLQPGTWAKASFKNGEREKIQLPTSALLTMNELSSVYLKKGEEFVLT
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEE
QVRVASPLDGEVEVLAGLKSGDKVAVDAYQVLLNKKQ
EEEECCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCC
>Mature Secondary Structure 
TSISRAFFLLLALASTQVQAASVETIEVLTKPYANWVTLDATIEAVKAATVSAQTSGRI
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHEEECCCCEE
VKLNYDVNDVVPEGAALLEITSKEQGAELASFEADLAKAKALNVEAQAQYKRYKELFPQG
EEEECCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
AISKGAMDEATANAKATEQAVTAAQARVIKASESLKYTVVSAPFSGVVTERFVELGETVS
CCCCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHCCCCC
PGQALLSGFSASQMRAITQVPQRYINQLKIAPEFLVRLSDGRELTSKDLTIFSFADPVSH
CHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHEEECCCCEECCCCEEEEEECCCCCC
SYQVRINLPENEANLQPGTWAKASFKNGEREKIQLPTSALLTMNELSSVYLKKGEEFVLT
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCEEEEE
QVRVASPLDGEVEVLAGLKSGDKVAVDAYQVLLNKKQ
EEEECCCCCCCEEEEEECCCCCEEHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]