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The map label for this gene is trpE [H]

Identifier: 160875912

GI number: 160875912

Start: 3334320

End: 3335999

Strand: Direct

Name: trpE [H]

Synonym: Sbal195_2801

Alternate gene names: 160875912

Gene position: 3334320-3335999 (Clockwise)

Preceding gene: 160875905

Following gene: 160875913

Centisome position: 62.36

GC content: 49.29

Gene sequence:

>1680_bases
ATGCCCAAACAGACATTCGCACGCTCAAGCACACTCAAGGCGGCATTAACCTACCACAGCGATCCACTGCGCTTGTATCA
GCACATTACCCAAGATGCGCCCCATACTATGTTGTTGGAGTCGGCCGAAATCGACAGTAAAGATCACTTAAAAAGCATGG
TGATGACCCATGCCGCCATTATGATCCGCTGCGACGGTTATCAACTGACCTTTACCGCACTGACCGACAATGGCGCGAGC
TTACTTACCCCAATCGAAACCTTCTTCAGCGCGAGCGGCGATCGTGCTGATATGAGTGCCAATCTAGTCCGTGATAACTT
GACCTTAGTGGTGACACTGCAAAAAGACACTAAGCTGCAGGATGAAGATGCACGCTTAAAATCTACTTCGCCACTCGATG
GCCTACGGATGTTTATCCAGCAAATTGATTGTGGCACTCATACTGACAGCCAAAGTAAACCCGCCTTTGAGGATCTGTTT
TTAGGTGGCGTGTTGGCCTACGACTTGATTGATACCGTCGAACCGCTGCCAGCCGTACCGAACCGCGATAATGATTGCCC
AGACTACTTATTTTACCTCGCTGAAACCTTAATCCTTATCGACCATAAACTGAAACAAGCCGACATCATTACCCATAATT
TCAGTCGTGATTCCGCCCAGCATACCGCCATCACCGCAGCGCTGAGCGAGCGAGTTCAGCATCTAAGCACACAATGTAAA
ACCCTCGGTAATTCACCTGCCGATGTGCCGACACTGGTCGCCATCGACGCTACTGAGCAAGTCAATATTTCCGATGAGGT
GTTCAAACAAACCGTTATCGATTTGAAAGAACACATTATTGCGGGCGATATTTTCCAAGTGGTGCCATCGCGTAGTTTTA
GTTTACCTTGCCCGAATACCTTAGGGGCTTATCGCGCCCTGCGTCTAACTAACCCAAGCCCTTACATGTTTTATTTCAGA
GGCCAAGATTTCACGCTTTTTGGTGCTTCACCAGAAAGTGCGCTTAAGTACGAGGCCAGCAGCAATCAAGTCGAAGTCTA
CCCGATTGCCGGCACCCGCAAACGCGGCAAAACCGCCACGGGCGAGATTGATTTTGACTTAGACAGCCGCATTGAACTTG
AACTGCGTTTAGATAAAAAAGAACTGTCAGAACACTTAATGTTGGTTGATTTAGCTCGCAACGATATCGCGCGCATCAGC
CAAAGCGGCAGCCGTAAAGTCGCTGAATTATTGAAAGTTGATCGCTATTCTCACGTGATGCACCTTGTCAGTCGCGTAAC
GGGTCAATTGCGCCAAGATTTAGATGCGCTGCATGCTTATCAGGCCTGTATGAATATGGGTACTTTAGTTGGCGCCCCCA
AAGTAAGCGCATCACAACTGGTTCGCCAAGCAGAAAAAGCCCGCCGTGGCAGCTACGGCGGCGCTGTGGGTTACCTTAAT
GCCCTTGGGGATATGGACACTTGCATAGTGATCCGCTCCGCCTTTGTTAAAAATGGTACCGCCTTTATTCAAGCGGGCGC
GGGCGTGGTATTTGATTCGGATCCCCAAAGCGAGGCAGATGAAACCCGTCAAAAAGCCCAAGCCGTGATTTCAGCCATCA
AGATGGGCGCTGGACTGCTAGCAAATGAATCGTCAGCTCAATCCACTTCAGCACAATCCTCTTCAGTGCAATATAAATAG

Upstream 100 bases:

>100_bases
GTTAGGTGCGAAAAATGTCGGCAGACTCGGGTAACAAGATTAAGAAAGCGAGATAACTCATGATGTTAAAGACATTTTAT
AAGGTAGCTGGAGTATGAAC

Downstream 100 bases:

>100_bases
GAGCCAAACATGAAACTCTATCTACTCGATAACTTTGACTCCTTTACCTACAACTTAGTGGATCAATTTCGCAGCCTAGG
CTGTGAAGTGGTGATTTACC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAIMIRCDGYQLTFTALTDNGAS
LLTPIETFFSASGDRADMSANLVRDNLTLVVTLQKDTKLQDEDARLKSTSPLDGLRMFIQQIDCGTHTDSQSKPAFEDLF
LGGVLAYDLIDTVEPLPAVPNRDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQHTAITAALSERVQHLSTQCK
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFR
GQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARIS
QSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLLANESSAQSTSAQSSSVQYK

Sequences:

>Translated_559_residues
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAIMIRCDGYQLTFTALTDNGAS
LLTPIETFFSASGDRADMSANLVRDNLTLVVTLQKDTKLQDEDARLKSTSPLDGLRMFIQQIDCGTHTDSQSKPAFEDLF
LGGVLAYDLIDTVEPLPAVPNRDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQHTAITAALSERVQHLSTQCK
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFR
GQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARIS
QSGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLLANESSAQSTSAQSSSVQYK
>Mature_558_residues
PKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAIMIRCDGYQLTFTALTDNGASL
LTPIETFFSASGDRADMSANLVRDNLTLVVTLQKDTKLQDEDARLKSTSPLDGLRMFIQQIDCGTHTDSQSKPAFEDLFL
GGVLAYDLIDTVEPLPAVPNRDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQHTAITAALSERVQHLSTQCKT
LGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNTLGAYRALRLTNPSPYMFYFRG
QDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTATGEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQ
SGSRKVAELLKVDRYSHVMHLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLNA
LGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLLANESSAQSTSAQSSSVQYK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=516, Percent_Identity=53.2945736434108, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1788114, Length=440, Percent_Identity=29.5454545454545, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI87082077, Length=332, Percent_Identity=26.8072289156627, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786809, Length=228, Percent_Identity=27.6315789473684, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320935, Length=426, Percent_Identity=35.6807511737089, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6324361, Length=231, Percent_Identity=27.2727272727273, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005257
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 61309; Mature: 61178

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAI
CCCHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHEEE
MIRCDGYQLTFTALTDNGASLLTPIETFFSASGDRADMSANLVRDNLTLVVTLQKDTKLQ
EEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCCC
DEDARLKSTSPLDGLRMFIQQIDCGTHTDSQSKPAFEDLFLGGVLAYDLIDTVEPLPAVP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
NRDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQHTAITAALSERVQHLSTQCK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNT
HCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
LGAYRALRLTNPSPYMFYFRGQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTAT
HHHHEEEEECCCCCEEEEEECCEEEEECCCCHHHEEEECCCCEEEEEECCCCCCCCCCCC
GEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLKVDRYSHVM
CEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLL
HHCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ANESSAQSTSAQSSSVQYK
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PKQTFARSSTLKAALTYHSDPLRLYQHITQDAPHTMLLESAEIDSKDHLKSMVMTHAAI
CCHHHHHHHHHHEEEEECCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHEEE
MIRCDGYQLTFTALTDNGASLLTPIETFFSASGDRADMSANLVRDNLTLVVTLQKDTKLQ
EEEECCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHEEECCEEEEEEECCCCCCC
DEDARLKSTSPLDGLRMFIQQIDCGTHTDSQSKPAFEDLFLGGVLAYDLIDTVEPLPAVP
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
NRDNDCPDYLFYLAETLILIDHKLKQADIITHNFSRDSAQHTAITAALSERVQHLSTQCK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLGNSPADVPTLVAIDATEQVNISDEVFKQTVIDLKEHIIAGDIFQVVPSRSFSLPCPNT
HCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
LGAYRALRLTNPSPYMFYFRGQDFTLFGASPESALKYEASSNQVEVYPIAGTRKRGKTAT
HHHHEEEEECCCCCEEEEEECCEEEEECCCCHHHEEEECCCCEEEEEECCCCCCCCCCCC
GEIDFDLDSRIELELRLDKKELSEHLMLVDLARNDIARISQSGSRKVAELLKVDRYSHVM
CEEEECCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
HLVSRVTGQLRQDLDALHAYQACMNMGTLVGAPKVSASQLVRQAEKARRGSYGGAVGYLN
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
ALGDMDTCIVIRSAFVKNGTAFIQAGAGVVFDSDPQSEADETRQKAQAVISAIKMGAGLL
HHCCCHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCC
ANESSAQSTSAQSSSVQYK
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1773058; 12620739 [H]