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The map label for this gene is folX [H]

Identifier: 160875890

GI number: 160875890

Start: 3309668

End: 3310030

Strand: Direct

Name: folX [H]

Synonym: Sbal195_2779

Alternate gene names: 160875890

Gene position: 3309668-3310030 (Clockwise)

Preceding gene: 160875887

Following gene: 160875891

Centisome position: 61.89

GC content: 42.7

Gene sequence:

>363_bases
ATGAAACCAGAAACCGCGATTATACGCATTAAAAACTTAAGACTTCGTACTTTTATTGGCATTAAAGAAGATGAAATTCA
AAATCGCCAAGACGTGATCATCAATGTCGTGATCCATTACTGTGCCGAACGTGCCCGTAACAGTGATAATGTTGAGGATG
CACTCAATTACCGCACTATCACCAAAAAGATCATTGAGCTGATTGAGAACAACCGTTTCTCATTACTCGAAAATCTTACC
AGCCAAACGCTGGCCATCGCCAGTGAGCATCCTTGGGTTGAATTTGCCAGTGTCGAAATCGACAAACCCCATGCCCTGCG
CTTTGCCGATTCAGTCTCGATGGAGTTGTGTTATCAGAAATAA

Upstream 100 bases:

>100_bases
ATTTATTAAAAATCCTTCTTGATCTTAGATAAAATTGTTAGGCTAACCCGAGAACACACTTAACCTCAGAAACCTTAGCT
TAAGATAGCCATTTGCCATT

Downstream 100 bases:

>100_bases
TCTCGCTAGAAATACCCTGACTAAGTGATCGTTGCACACCGTATTTCGGTATATATCCTCATAGCTCAACCGATAAGAGA
GGTTCCATGAATATACTGAT

Product: D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase

Products: L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

Alternate protein names: Dihydroneopterin triphosphate 2'-epimerase [H]

Number of amino acids: Translated: 120; Mature: 120

Protein sequence:

>120_residues
MKPETAIIRIKNLRLRTFIGIKEDEIQNRQDVIINVVIHYCAERARNSDNVEDALNYRTITKKIIELIENNRFSLLENLT
SQTLAIASEHPWVEFASVEIDKPHALRFADSVSMELCYQK

Sequences:

>Translated_120_residues
MKPETAIIRIKNLRLRTFIGIKEDEIQNRQDVIINVVIHYCAERARNSDNVEDALNYRTITKKIIELIENNRFSLLENLT
SQTLAIASEHPWVEFASVEIDKPHALRFADSVSMELCYQK
>Mature_120_residues
MKPETAIIRIKNLRLRTFIGIKEDEIQNRQDVIINVVIHYCAERARNSDNVEDALNYRTITKKIIELIENNRFSLLENLT
SQTLAIASEHPWVEFASVEIDKPHALRFADSVSMELCYQK

Specific function: Catalyzes the epimerization of carbon 2' of the side chain of dihydroneopterin triphosphate (H2NTP) to form dihydromonapterin triphosphate (H2MTP) [H]

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI1788641, Length=120, Percent_Identity=68.3333333333333, Blast_Score=171, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: 5.-.-.- [C]

Molecular weight: Translated: 13972; Mature: 13972

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPETAIIRIKNLRLRTFIGIKEDEIQNRQDVIINVVIHYCAERARNSDNVEDALNYRTI
CCCCCEEEEEECCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TKKIIELIENNRFSLLENLTSQTLAIASEHPWVEFASVEIDKPHALRFADSVSMELCYQK
HHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCCHHHHHCCCCHHEECCC
>Mature Secondary Structure
MKPETAIIRIKNLRLRTFIGIKEDEIQNRQDVIINVVIHYCAERARNSDNVEDALNYRTI
CCCCCEEEEEECCEEEEEECCCHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
TKKIIELIENNRFSLLENLTSQTLAIASEHPWVEFASVEIDKPHALRFADSVSMELCYQK
HHHHHHHHHCCHHHHHHHHHHHHEEECCCCCCEEEEEEEECCCCHHHHHCCCCHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Erythro-7,8-Dihydroneopterin Triphosphate [C]

Specific reaction: D-Erythro-7,8-Dihydroneopterin Triphosphate = L-Threo-7,8-Dihydroneopterin Triphosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]