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The map label for this gene is apt

Identifier: 160875803

GI number: 160875803

Start: 3198209

End: 3198763

Strand: Reverse

Name: apt

Synonym: Sbal195_2691

Alternate gene names: 160875803

Gene position: 3198763-3198209 (Counterclockwise)

Preceding gene: 160875804

Following gene: 160875802

Centisome position: 59.82

GC content: 45.05

Gene sequence:

>555_bases
ATGATGGCTATGAATACAGAAACCTTATCCTTGATAAAGCAAAGCATTAAAACGATTCCTAATTATCCTAAGGAAGGGAT
TTTATTTCGAGATGTCACCAGTTTGCTTGAGAATGCAGCCGCCTATAAAGCGACCATCGACTTGTTAGTTGAACATTATC
GTGGCCAAGGCTTTACCAAAATTGTGGGCACTGAGGCCCGTGGTTTCTTGTTCGGCGCGCCGCTGGCTTTAGAATTGGGT
GTGGGTTTTGTACCTGTGCGTAAACCGGGTAAATTACCGCGTGCGACTATCAGCCAAAGCTATGAACTGGAATACGGTCA
CGATAGCCTAGAAATTCATACCGATGCGATTAACCCAAATGACAAAGTGCTCGTCGTTGACGATTTACTCGCGACTGGCG
GTACTATTGAAGCGACCGTTAAACTCATTCGCCAACTGGGCGGTGAAGTTAAACATGCGGCCTTTGTGATCTCATTACCT
GATTTAGGTGGTGAAGCACGTTTAACCGCTTTAGGGCTTGAGTTGGTTAAACTTTGTGAGTTTGAAGGCGAATAA

Upstream 100 bases:

>100_bases
TTTGTCCGACTTTCGACAATGCGTCCACCCAGTGTGGACGTTTTGTTTTATACCGCCAACGCTAGGTTGGTGAATTGATT
AAGTAACTTATTAAGTAAAT

Downstream 100 bases:

>100_bases
ATCTGCAGCTAAAGGCGCCTTGGGATAGTTTGATGGCATGTCAAATCATGACATGTTATCTTTCAAAGTTCTCGGGGCGC
ATGCTCCCGCTCTTGTATCA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
VGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAINPNDKVLVVDDLLATGGTIEATVKLIRQLGGEVKHAAFVISLP
DLGGEARLTALGLELVKLCEFEGE

Sequences:

>Translated_184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
VGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAINPNDKVLVVDDLLATGGTIEATVKLIRQLGGEVKHAAFVISLP
DLGGEARLTALGLELVKLCEFEGE
>Mature_184_residues
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEHYRGQGFTKIVGTEARGFLFGAPLALELG
VGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAINPNDKVLVVDDLLATGGTIEATVKLIRQLGGEVKHAAFVISLP
DLGGEARLTALGLELVKLCEFEGE

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=43.7869822485207, Blast_Score=145, Evalue=3e-35,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=47.3684210526316, Blast_Score=127, Evalue=5e-30,
Organism=Escherichia coli, GI1786675, Length=182, Percent_Identity=69.7802197802198, Blast_Score=251, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=43.9024390243902, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=164, Percent_Identity=43.2926829268293, Blast_Score=118, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=36.4161849710983, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136334, Length=173, Percent_Identity=45.0867052023121, Blast_Score=135, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SHEB2 (B8E700)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357696.1
- ProteinModelPortal:   B8E700
- SMR:   B8E700
- GeneID:   7088302
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1768
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19936; Mature: 19936

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEHYRGQGFTK
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IVGTEARGFLFGAPLALELGVGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAINPN
EECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEECCCCCC
DKVLVVDDLLATGGTIEATVKLIRQLGGEVKHAAFVISLPDLGGEARLTALGLELVKLCE
CCEEEEEHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
FEGE
CCCC
>Mature Secondary Structure
MMAMNTETLSLIKQSIKTIPNYPKEGILFRDVTSLLENAAAYKATIDLLVEHYRGQGFTK
CCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
IVGTEARGFLFGAPLALELGVGFVPVRKPGKLPRATISQSYELEYGHDSLEIHTDAINPN
EECCCCCCEEEECCEEEECCCCEEECCCCCCCCHHHHCCCEEEEECCCCEEEEECCCCCC
DKVLVVDDLLATGGTIEATVKLIRQLGGEVKHAAFVISLPDLGGEARLTALGLELVKLCE
CCEEEEEHHHHCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
FEGE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA