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The map label for this gene is clpA [H]

Identifier: 160875697

GI number: 160875697

Start: 3057941

End: 3060208

Strand: Reverse

Name: clpA [H]

Synonym: Sbal195_2585

Alternate gene names: 160875697

Gene position: 3060208-3057941 (Counterclockwise)

Preceding gene: 160875698

Following gene: 160875693

Centisome position: 57.23

GC content: 48.5

Gene sequence:

>2268_bases
ATGCTGAACAAAGACCTGGAAGTCACCTTAAATCTGGCGTTTCAGCAAGCCAGAGACGCGCGTCACGAGTATATGACAGT
GGAACATCTGTTATTAGCTCTGATCGACAATCCTGCGGCTCAAGAAGCGTTAATCGCCTGTGGAGCGAATCTAGATAAAC
TCAGAGATGAAGTGGCAAGCTTTATCCAACAAACAACCCCAATCATTGCCGATATTGATGATGACAAAGAAACTCAGCCG
ACGCTGGGGTTCCAACGAGTGCTGCAACGTGCAGTATTCCATGTGCAGTCATCGGGTCGCAATGAAGTGAACGGCGCTAA
CGTGTTAGTCGCCATTTTCAGTGAGCAAGAATCCCAAGCCGTGTATTTACTGCGCCGCTGCGATATTAGTCGCCTAGACG
TTGTGAATTTTATTTCCCATGGTTTCGCCAAAAATGATGATGCTGAGTCACATCAAGATCAAGAACGGGTTGAAGATCAG
GGCGAAAGCAGCGAAGAGCGCAGCATGTTGTCGCAATTTGCGTCCAACTTAAATCAACTTGCTAAGCAAGGGATCATCGA
CCCACTGATTGGTCGTGATCAAGAAATTGAGCGCGCGATTCAAACCCTGTGCCGTCGCCGTAAAAATAATCCACTGTTAG
TGGGTGAGGCGGGCGTAGGTAAAACGGCGATTGCCGAAGGGTTGGCGTATCGCATCGTCAATAAACAAGTGCCCGATGTG
ATGCTTGAAGCCACAGTGTATTCCTTGGATTTAGGTTCACTGCTGGCGGGAACTAAGTATCGCGGCGACTTTGAAAAACG
CTTCAAGAACCTGTTAAAAGAACTGGCGGCTGATAAGCATGCCATCCTGTTCATCGATGAGATCCACACCATTATCGGTG
CGGGCGCGGCCTCTGGCGGCGTAATGGATGCCTCTAATCTGCTGAAACCTTTACTATCTAGCGGCAACTTACGCTGCATG
GGCTCGACAACCTTCCAAGAATATCAAAGTATTTTTGAGAAAGACCGCGCACTTGCACGTCGTTTCCAAAAGGTGGATAT
CAATGAGCCTTCAGTGGAAGAAACCACTAAGATTTTGATGGGGCTTAAGTCTAAATACGAAGAATATCATGGGGTTCGTT
ATACTCAGGCTGCGATCAGCAGCGCTGCGGTATTGTCGGCCAAGCACATCAATGACAGACATTTACCCGATAAAGCCATC
GATGTGATCGATGAAGCGGGTGCGCGTATGGTGATGTTGCCTATGAGCAAACGTAAAAAGACTATAGGCCAAGCCGAGAT
TGAGTCGATAGTGGCGAAAATGGCGCGTATCCCTGAGAAGTCGGTATCCGCCACTGATAAGGACTTACTGCGTAATCTTG
AGCGTAACCTTAAGATGGTGGTCTTTGGCCAAGACAAGGCCATTGAGAGTCTGAGTTCGGCCATTCGCTTATCGCGCAGT
GGCTTAGGCACAGACAGGAAACCTGTGGGTAGCTTCTTATTCGCGGGTCCCACCGGTGTGGGTAAAACCGAAGTCACTAA
CCAACTGGCCAACTGTTTGGGGATGAAACTGGTGCGCTTTGACATGTCTGAGTACATGGAAAGCCACACAGTGTCACGCT
TGATTGGTGCGCCTCCTGGATATGTGGGTTATGACCAAGGTGGCTTGCTCACCGATGCTGTGATTAAAAATCCGCACTGT
GTGGTGCTACTGGATGAAATCGAGAAGGCCCACCGCGATGTCTATAACTTGCTGTTGCAGGTGATGGATCACGGTACTTT
GACCGACAATAATGGTCGTAAGGCTGACTTCAGACACGTGACTTTGGTGATGACAACGAACGCGGGTGTTCAGGAGACTA
TTCGTAAGTCGATTGGCTTTACCCAACAAGATCACACTCAAGATGCGTTATCTGAAATTAATCGGGTATTTTCGCCAGAA
TTTCGAAATCGTCTCGATTCCATCATTTGGTTCAACCATTTGGATATGACGATTATCGCCAAAGTGGTCGATAAATTCTT
GGTGGAATTGCAGGCTCAATTGGATGCAAAACACGTTACTTTGGAAGTCAGCGACGAAGCCAGAACCTTGTTGGCCGAGA
AAGGCTACGACAAGAACATGGGCGCGCGTCCAATGGCTCGGGTGGTGACCGAATTGATCAAACGTCCATTGGCAGACGAG
ATCTTATTTGGTGTCTTAGAGTCAGGCGGTGTGGCGCATGTGGATGTGAAGGAGGGCGAGCTTGTCATTCGTACCGAACG
TCACGAAAAAGCGACAACAAAAGCTTAA

Upstream 100 bases:

>100_bases
AATCAATTTGCAAGACAAAACCAACATCCGTTACTGTGTTCGTTAGAGAAAGCATAAAACCGCTTTACTCTGTAGTCTGT
TGTTAATTTTGGGGGTGCTT

Downstream 100 bases:

>100_bases
CGCTTGATTATCCATTAGTTTTAGACATAAAAATGGCTGCAATTGCAGCCATTTTTTTCATCTTTCGCAAACAAAAAAAC
CCGGCCTTGCCGGGTTTTTA

Product: ATP-dependent Clp protease, ATP-binding subunit clpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGPTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA

Sequences:

>Translated_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGPTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
>Mature_755_residues
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVASFIQQTTPIIADIDDDKETQP
TLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQAVYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQ
GESSEERSMLSQFASNLNQLAKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGGVMDASNLLKPLLSSGNLRCM
GSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILMGLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAI
DVIDEAGARMVMLPMSKRKKTIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
GLGTDRKPVGSFLFAGPTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPGYVGYDQGGLLTDAVIKNPHC
VVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHVTLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPE
FRNRLDSIIWFNHLDMTIIAKVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=298, Percent_Identity=31.5436241610738, Blast_Score=145, Evalue=2e-34,
Organism=Escherichia coli, GI1787109, Length=732, Percent_Identity=70.0819672131148, Blast_Score=1071, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=408, Percent_Identity=42.4019607843137, Blast_Score=286, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6320464, Length=320, Percent_Identity=49.375, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=408, Percent_Identity=38.2352941176471, Blast_Score=255, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83827; Mature: 83827

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQGESSEERSMLSQFASNLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDRKPVGSFLFAGPTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MLNKDLEVTLNLAFQQARDARHEYMTVEHLLLALIDNPAAQEALIACGANLDKLRDEVAS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHH
FIQQTTPIIADIDDDKETQPTLGFQRVLQRAVFHVQSSGRNEVNGANVLVAIFSEQESQA
HHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCHHH
VYLLRRCDISRLDVVNFISHGFAKNDDAESHQDQERVEDQGESSEERSMLSQFASNLNQL
HHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AKQGIIDPLIGRDQEIERAIQTLCRRRKNNPLLVGEAGVGKTAIAEGLAYRIVNKQVPDV
HHCCCCCHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHH
MLEATVYSLDLGSLLAGTKYRGDFEKRFKNLLKELAADKHAILFIDEIHTIIGAGAASGG
HHHHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
VMDASNLLKPLLSSGNLRCMGSTTFQEYQSIFEKDRALARRFQKVDINEPSVEETTKILM
CCCHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSKYEEYHGVRYTQAAISSAAVLSAKHINDRHLPDKAIDVIDEAGARMVMLPMSKRKK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEECCHHHHH
TIGQAEIESIVAKMARIPEKSVSATDKDLLRNLERNLKMVVFGQDKAIESLSSAIRLSRS
HHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHC
GLGTDRKPVGSFLFAGPTGVGKTEVTNQLANCLGMKLVRFDMSEYMESHTVSRLIGAPPG
CCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGYDQGGLLTDAVIKNPHCVVLLDEIEKAHRDVYNLLLQVMDHGTLTDNNGRKADFRHV
CCCCCCCCCCHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEE
TLVMTTNAGVQETIRKSIGFTQQDHTQDALSEINRVFSPEFRNRLDSIIWFNHLDMTIIA
EEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHH
KVVDKFLVELQAQLDAKHVTLEVSDEARTLLAEKGYDKNMGARPMARVVTELIKRPLADE
HHHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHH
ILFGVLESGGVAHVDVKEGELVIRTERHEKATTKA
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]