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The map label for this gene is pyrD [H]

Identifier: 160875664

GI number: 160875664

Start: 3016511

End: 3017530

Strand: Reverse

Name: pyrD [H]

Synonym: Sbal195_2552

Alternate gene names: 160875664

Gene position: 3017530-3016511 (Counterclockwise)

Preceding gene: 160875665

Following gene: 160875663

Centisome position: 56.43

GC content: 43.43

Gene sequence:

>1020_bases
ATGTTTTATAAAATCGCACAGAAAGTCATGTTTCAGATGGATCCTGAGCGAGCTCACCATCTTGCTATAGGCAGTCTAAA
AATGACCGCCAATAGCCCGTTAACGTGTCTGTACGGACAAACGATTGCACCGGCTCCCGTGAGCGTTATGGGACTGACTT
TTCCTAACCCAGTGGGACTCGCTGCGGGTATGGACAAGGACGGCGAATCGATTGATGCCTTTCATGCGATGGGATTTGGT
CATGTTGAAGTGGGCACTGTGACCCCAAGACCACAACCCGGTAATGATTTACCCCGTCTATTTAGATTAAAGCCTGCCAA
AGGCATTATTAATCGCATGGGGTTCAATAATAAAGGTGTCGATAATCTGGTCAAAAATTTGATCGCTAAAAAGACCGACA
TTATGGTTGGCGTCAATATTGGTAAAAATAAAGACACCCCAGTAGAACAAGGTAAAGACGATTATTTGATCTGCATGGAT
AAAGTTTATCTCCATGCGGCTTATATTGCGGTGAATATTTCATCACCCAATACCCCAGGATTGCGATCGCTACAATATGG
CGATCTATTAGATGAATTATTGAGCGCAATTAAGACTAAGCAACTTGAGCTGGCCGAAAAGCATAAAAAATACGTGCCCA
TCGCGCTTAAAATTGCCCCAGATTTAACCATCGAAGAAATTGAAAATATTGCGCAAGCTTTGATTAAAAACAAATTTGAT
GGCGCAATTGCAACTAATACCACCTTAACGCGTGATGGTGTTAGCGGCCTTGCCAACGCCAATGAAAGCGGCGGCTTAAG
CGGCAAACCGTTGACAGAACTGTCTACTAAAGTGATCAAGCAGCTAGCTATGTGCTTGAAAGGGCAGATCCCGATCATCG
GTGTGGGCGGTATCAATAGTGCCGAAGATGCCTTAGCCAAATTTGATGCGGGTGCCACTATGGTGCAGATTTATTCGGGT
TTTATTTATCAAGGTCCGAAGTTAATTAAAGAAATTGTGAATGCATACCGCTTAAAATAA

Upstream 100 bases:

>100_bases
TAACCTTCTGATCCTTCATTGCGAAGGCCAAAAGTAAACTTATTATAACAATCAGAAGCCCTGGCGATCGCCGGGGCTTT
TTTTAGGTCGAGGAAAGTAC

Downstream 100 bases:

>100_bases
TGATCTAAAGATCAATGTAAAGATCTAAAATAAGATCTTATTCTTTAACAGCGATCTAAAAGGATCCCTAGATCGCTGTT
AAGATCCTATATTAGATCGA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MFYKIAQKVMFQMDPERAHHLAIGSLKMTANSPLTCLYGQTIAPAPVSVMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYLHAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIAQALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLAMCLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVNAYRLK

Sequences:

>Translated_339_residues
MFYKIAQKVMFQMDPERAHHLAIGSLKMTANSPLTCLYGQTIAPAPVSVMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYLHAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIAQALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLAMCLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVNAYRLK
>Mature_339_residues
MFYKIAQKVMFQMDPERAHHLAIGSLKMTANSPLTCLYGQTIAPAPVSVMGLTFPNPVGLAAGMDKDGESIDAFHAMGFG
HVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGVDNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMD
KVYLHAAYIAVNISSPNTPGLRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIAQALIKNKFD
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLAMCLKGQIPIIGVGGINSAEDALAKFDAGATMVQIYSG
FIYQGPKLIKEIVNAYRLK

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=42.7272727272727, Blast_Score=242, Evalue=4e-64,
Organism=Escherichia coli, GI1787177, Length=333, Percent_Identity=61.5615615615616, Blast_Score=431, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17509475, Length=345, Percent_Identity=41.7391304347826, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI281361352, Length=293, Percent_Identity=43.0034129692833, Blast_Score=228, Evalue=6e-60,
Organism=Drosophila melanogaster, GI17137316, Length=293, Percent_Identity=43.0034129692833, Blast_Score=228, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36547; Mature: 36547

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYKIAQKVMFQMDPERAHHLAIGSLKMTANSPLTCLYGQTIAPAPVSVMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHEEEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYLHAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHEEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIAQALIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLAMCLKGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVNAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYKIAQKVMFQMDPERAHHLAIGSLKMTANSPLTCLYGQTIAPAPVSVMGLTFPNPVGL
CHHHHHHHHHHHCCHHHHHEEEEEEEEEECCCCEEEEECCCCCCCCCEEEEECCCCCCCC
AAGMDKDGESIDAFHAMGFGHVEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV
CCCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCCCHHHCCCCHHHHHHHCCCCCCCH
DNLVKNLIAKKTDIMVGVNIGKNKDTPVEQGKDDYLICMDKVYLHAAYIAVNISSPNTPG
HHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEEEEHHHHHEEEEEEEEEECCCCCCC
LRSLQYGDLLDELLSAIKTKQLELAEKHKKYVPIALKIAPDLTIEEIENIAQALIKNKFD
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCC
GAIATNTTLTRDGVSGLANANESGGLSGKPLTELSTKVIKQLAMCLKGQIPIIGVGGINS
CCEECCCEECCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
AEDALAKFDAGATMVQIYSGFIYQGPKLIKEIVNAYRLK
HHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA