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The map label for this gene is ndk

Identifier: 160875605

GI number: 160875605

Start: 2946853

End: 2947284

Strand: Reverse

Name: ndk

Synonym: Sbal195_2493

Alternate gene names: 160875605

Gene position: 2947284-2946853 (Counterclockwise)

Preceding gene: 160875606

Following gene: 160875604

Centisome position: 55.12

GC content: 45.83

Gene sequence:

>432_bases
ATGGCGATCGAACGCACATTTTCTATTATCAAACCTGATGCTGTTGCAAAAAACCACATCGGTGCTATCTACAATCGTTT
TGAAACTGCTGGTCTTAAGATCGTTGCATCAAAAATGTTACACCTGACTAAAGAACAAGCTGAAGGTTTCTATGCTGAGC
ATAGCGAGCGCGGCTTCTTCGGTGCTCTGGTTGCATTCATGACTTCTGGTCCTATCATGGTCCAAGTATTAGAAGGCGAA
AACGCTGTTTTAGCTCACCGTGAAATTTTAGGTGCAACTAACCCAGCTCAAGCGGCTCCTGGTACTATCCGTGCTGATTT
CGCTGAAAGCATTGACGAAAACGCGGCTCACGGCTCTGATGCTGTTGAATCTGCTGCACGTGAAATTGCTTACTTCTTCA
GCGCTGAAGAACTGTGTCCACGCACTCGTTAA

Upstream 100 bases:

>100_bases
GCAATATCTCAGACTAATTTGCTATAAAGATAGGATTTAGCTTTTAAATTTCGTATAATCCGCGCGAATTTTTTAAACTT
GCTGACAAAGGAAGCTAGTT

Downstream 100 bases:

>100_bases
TTCGATGCTAAGACTTAAAAAGGAGCCCTAGGCTCCTTTTTTATTGGCTGCAATTTAGCGAATACTGCTTGCCGTGCGCA
ATGAATCTAATGCCGCGATA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVASKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGE
NAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDAVESAAREIAYFFSAEELCPRTR

Sequences:

>Translated_143_residues
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVASKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGE
NAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDAVESAAREIAYFFSAEELCPRTR
>Mature_142_residues
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVASKMLHLTKEQAEGFYAEHSERGFFGALVAFMTSGPIMVQVLEGEN
AVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSDAVESAAREIAYFFSAEELCPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=135, Percent_Identity=49.6296296296296, Blast_Score=139, Evalue=6e-34,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=46.3235294117647, Blast_Score=133, Evalue=6e-32,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=46.3235294117647, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=46.3235294117647, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=46.3235294117647, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=46.3235294117647, Blast_Score=132, Evalue=8e-32,
Organism=Homo sapiens, GI4557797, Length=139, Percent_Identity=44.6043165467626, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI38045913, Length=139, Percent_Identity=44.6043165467626, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=41.9117647058824, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=40.4411764705882, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=37.410071942446, Blast_Score=93, Evalue=9e-20,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=35.5555555555556, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=33.5766423357664, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=30.4347826086957, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=72.7272727272727, Blast_Score=214, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=46.6666666666667, Blast_Score=129, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=48.5294117647059, Blast_Score=136, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=50.3597122302158, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.0746268656716, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_SHEB2 (B8E9E1)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357897.1
- ProteinModelPortal:   B8E9E1
- SMR:   B8E9E1
- GeneID:   7086804
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1970
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15470; Mature: 15338

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVASKMLHLTKEQAEGFYAEHSERGFF
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
GALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCH
AVESAAREIAYFFSAEELCPRTR
HHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AIERTFSIIKPDAVAKNHIGAIYNRFETAGLKIVASKMLHLTKEQAEGFYAEHSERGFF
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHH
GALVAFMTSGPIMVQVLEGENAVLAHREILGATNPAQAAPGTIRADFAESIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCH
AVESAAREIAYFFSAEELCPRTR
HHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA