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The map label for this gene is ppiB [H]

Identifier: 160874740

GI number: 160874740

Start: 1961213

End: 1961707

Strand: Reverse

Name: ppiB [H]

Synonym: Sbal195_1623

Alternate gene names: 160874740

Gene position: 1961707-1961213 (Counterclockwise)

Preceding gene: 160874742

Following gene: 160874739

Centisome position: 36.69

GC content: 44.24

Gene sequence:

>495_bases
ATGATCACAATACACACCAATTTGGGCGACATTAAACTGCAACTGAACGCTGAAAAAGCGCCGTTAACAGTAGCAAACTT
CATGAAATATGTTGACGAAGGTTTCTTCGACGGCACTATCTTCCACCGTGTGATTGACGGTTTCATGATCCAAGGTGGTG
GCTTCAACGAAGACATGAGCCAAAAGCGTTGTAACGAGCCAGTGAAAAACGAAGCCAATAACGGTTTATCAAATCGTACT
GGTACTGTTGCTATGGCACGTACTTCTGATCCACATTCAGCCACTGCACAGTTCTTCATTAACGTGAACGACAACACTTT
CCTCGATTTTAAATCAGAAACCTCACAGGGCTGGGGCTACTGCGTATTCGGCGAAATCGTTGAAGGCATGGATATTATCG
AAAAAATCAAAGCTGTTAGCACTGGCAACCGTGGCATGCATCAAGATGTGCCATTAGAAGCCATTGTGATTGAAAAAGTC
AGCGTTGCGGCATAA

Upstream 100 bases:

>100_bases
GAGTCAGTCTACCACGGCCTGACAGGTTTTGAATACTGCACTTTGCGCGCAATCCGAGATAAGTTAGAATCGCGCCACTA
TTTACAGAGAGTATGAAAAC

Downstream 100 bases:

>100_bases
TCCCTGCGAATGCGAACTTTATTTATAGGCGATCTGCACCTAAGTGCAGATCGTCTTGATATCACCCAAGCGTTCACTCG
CTTCCTCGACACTGAACTCG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MITIHTNLGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFNEDMSQKRCNEPVKNEANNGLSNRT
GTVAMARTSDPHSATAQFFINVNDNTFLDFKSETSQGWGYCVFGEIVEGMDIIEKIKAVSTGNRGMHQDVPLEAIVIEKV
SVAA

Sequences:

>Translated_164_residues
MITIHTNLGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFNEDMSQKRCNEPVKNEANNGLSNRT
GTVAMARTSDPHSATAQFFINVNDNTFLDFKSETSQGWGYCVFGEIVEGMDIIEKIKAVSTGNRGMHQDVPLEAIVIEKV
SVAA
>Mature_164_residues
MITIHTNLGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFNEDMSQKRCNEPVKNEANNGLSNRT
GTVAMARTSDPHSATAQFFINVNDNTFLDFKSETSQGWGYCVFGEIVEGMDIIEKIKAVSTGNRGMHQDVPLEAIVIEKV
SVAA

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=31.7073170731707, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=31.7073170731707, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=32.9268292682927, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI19557636, Length=171, Percent_Identity=29.2397660818713, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI24308049, Length=175, Percent_Identity=30.2857142857143, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI7706339, Length=165, Percent_Identity=28.4848484848485, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI310129267, Length=142, Percent_Identity=33.8028169014084, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI310120620, Length=142, Percent_Identity=33.8028169014084, Blast_Score=64, Evalue=4e-11,
Organism=Homo sapiens, GI310110104, Length=142, Percent_Identity=34.5070422535211, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=32.5581395348837, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=64.4171779141104, Blast_Score=227, Evalue=3e-61,
Organism=Escherichia coli, GI1789763, Length=161, Percent_Identity=53.416149068323, Blast_Score=183, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=166, Percent_Identity=30.7228915662651, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=31.5068493150685, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=166, Percent_Identity=33.7349397590361, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17532641, Length=164, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=34.3949044585987, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=166, Percent_Identity=30.7228915662651, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922912, Length=138, Percent_Identity=34.0579710144928, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24652460, Length=167, Percent_Identity=25.748502994012, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18039; Mature: 18039

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIHTNLGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFNEDMS
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCHH
QKRCNEPVKNEANNGLSNRTGTVAMARTSDPHSATAQFFINVNDNTFLDFKSETSQGWGY
HHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCE
CVFGEIVEGMDIIEKIKAVSTGNRGMHQDVPLEAIVIEKVSVAA
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHCCCC
>Mature Secondary Structure
MITIHTNLGDIKLQLNAEKAPLTVANFMKYVDEGFFDGTIFHRVIDGFMIQGGGFNEDMS
CEEEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCHH
QKRCNEPVKNEANNGLSNRTGTVAMARTSDPHSATAQFFINVNDNTFLDFKSETSQGWGY
HHHCCCCHHHHCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCEEEEECCCCCCCCCE
CVFGEIVEGMDIIEKIKAVSTGNRGMHQDVPLEAIVIEKVSVAA
EEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2007139; 9278503; 1864365; 9298646; 9600841; 1606970; 8601841 [H]